切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (04) : 311 -314. doi: 10.3877/cma.j.issn.2096-1537.2017.04.017

所属专题: 文献

专家论坛

肠道与全身性严重感染
陈德昌1,()   
  1. 1. 100730 中国医学科学院北京协和医院重症医学科
  • 收稿日期:2017-07-10 出版日期:2017-11-28
  • 通信作者: 陈德昌

Gut and sepsis

Dechang Chen1()   

  • Received:2017-07-10 Published:2017-11-28
  • Corresponding author: Dechang Chen
引用本文:

陈德昌. 肠道与全身性严重感染[J]. 中华重症医学电子杂志, 2017, 03(04): 311-314.

Dechang Chen. Gut and sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(04): 311-314.

图1 正常肠上皮细胞的选择性通透功能(图片来源:维基百科)
图2 肠上皮细胞旁通透途径功能异常的机制(图片来源:维基百科)
1
Galeski DF, Edwards JM, Kallan MJ, et al. Benchmarking the incidence and mortality of severe sepsis in the United States [J]. Crit Care Med, 2013, 41(5):1167-1174.
2
Marshall JC, The microbiology of multiple organ failure [J]. Arch Surg, 1988, 123(3):309-315.
3
Border JR, Hassett J, LaDuca J, et al. The gut origin septic states in blunt multiple trauma(ISS=40) in the ICU [J]. Ann Surg, 1987, 206(4):427-448.
4
Meakins J, Marshall J. The gastrointestinal tract:The ″motor″ of MOF [J]. Arch Surg, 1986, 121:197-201.
5
Moore FA, Moore EE, Poggetti R, et al. Gut bacterial translocation via the portal vein:a clinical perspective with major torso trauma [J]. J Trauma, 1991, 31(5):629-636.
6
Defazio J, Fleming ID, Shakhsheer B, et al. The opposing forces of the intestinal microbiome and the emerging pathobiome [J]. Surg Clin North Am, 2014, 94(6):1151-1161.
7
Babrowski T, Romanowski K, Fink D, et al. The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis [J]. Surgery, 2013, 153(1):36-43.
8
Groschwitz KR, Hogan SP. Intestinal barrier function:molecular regulation and disease pathogenesis [J]. J Allergy Clin Immunol, 2009, 124 (1):3-22.
9
Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation,autoimmunity,and cancerp [J]. Physiol Rev, 2011, 91(1):151-175.
10
Helander HF, Fandriks L. Surface area of the digestive tract-revisited [J]. Scand J Gastroenterol, 2014, 49 (6):681-689.
11
Klingensmith NJ, Coopersmith CM. The gut as the motor of multiple organ dysfunction in critical illness [J]. Crit Care Clin, 2016, 32(2):203-212.
12
Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness [J]. Trends Mol Med, 2014, 20(4):214-223.
No related articles found!
阅读次数
全文


摘要