切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2019, Vol. 05 ›› Issue (04) : 359 -363. doi: 10.3877/cma.j.issn.2096-1537.2019.04.012

所属专题: 文献

综述

生物标志物对急性胰腺炎严重程度的早期预测
贾媛媛1, 赵冰1, 马丽1, 陈影1, 盛慧球1, 毛恩强1, 陈尔真1,()   
  1. 1. 200025 上海交通大学医学院附属瑞金医院急诊科
  • 收稿日期:2018-12-31 出版日期:2019-11-28
  • 通信作者: 陈尔真
  • 基金资助:
    国家自然科学基金资助项目(81772107); 上海市科学技术委员会科研计划项目(18411966400); 上海市卫生计生系统重要薄弱学科建设计划任务书(2016ZB0206)

Advance of biological markers in study on early prediction value of acute pancreatitis

Yuanyuan Jia1, Bing Zhao1, Li Ma1, Ying Chen1, Huiqiu Sheng1, Enqiang Mao1, Erzhen Chen1,()   

  1. 1. Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2018-12-31 Published:2019-11-28
  • Corresponding author: Erzhen Chen
  • About author:
    Corresponding author: Chen Erzhen, Email:
引用本文:

贾媛媛, 赵冰, 马丽, 陈影, 盛慧球, 毛恩强, 陈尔真. 生物标志物对急性胰腺炎严重程度的早期预测[J]. 中华重症医学电子杂志, 2019, 05(04): 359-363.

Yuanyuan Jia, Bing Zhao, Li Ma, Ying Chen, Huiqiu Sheng, Enqiang Mao, Erzhen Chen. Advance of biological markers in study on early prediction value of acute pancreatitis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(04): 359-363.

急性胰腺炎是全球范围内三大消化道疾病之一,根据其严重程度可分为轻度急性胰腺炎、中度重症急性胰腺炎、重度急性胰腺炎。中、重度急性胰腺炎病情重、进展迅速、病死率高。早期识别急性胰腺炎严重程度并尽早加强护理与治疗,可改变患者病程、住院时间及病死率。生物标志物具有标本容易获取、检测重复性好、稳定性高等优点,寻找有效的早期评估急性胰腺炎病情的生物标志物有助于胰腺炎的诊疗。本文就生物标志物对急性胰腺炎严重程度的早期预测研究进展做一综述。

Acute pancreatitis is one of the three most important diseases of the digestive system in the worldwide. It can be categorized into mild acute pancreatitis (MAP), moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP). MSAP and SAP are severe, rapid progress and high mortality disease. Early recognition of the severity of pancreatitis and early appropriate care can change the course of disease, short the hospital stay and reduce mortality. Biological markers have attracted much attention due to their accessibility, high reproducibility and stability. Finding out the effective biomarkers for early assessment of acute pancreatitis is helpful for diagnosis and treatment. We reviewed the advances of biological marker for AP severity early prediction.

1
Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus [J]. Gut, 2013, 62(1): 102-111.
2
Crockett SD, Wani S, Gardner TB, et al. American Gastroenterological Association Institute Guidelineon Initial Management of Acute Pancreatitis [J]. Gastroenterology, 2018, 154(4): 1096-1101.
3
Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: Update 2018 [J]. Gastroenterology, 2018. DOI: 10.1053/j.gastro.2018.08.063.
4
Hazra N, Gulliford M. Evaluating pancreatitis in primary care: a population-based cohort study [J]. Br J Gen Pract, 2014, 64(622): e295-301.
5
Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simple parameter of systemic inflammation and stress incritically ill [J]. Bratisl Lek Listy, 2001, 102(1): 5-14.
6
Shen Y, Cui N, Miao B, et al. Immune dysregulation in patients with severe acute pancreatitis [J]. Inflammation, 2011, 34(1): 36-42.
7
Pinhu L, Qin Y, Xiong B, et al. Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes [J]. Inflammation, 2014, 37(4): 1202-1212.
8
Qi X, Yang F, Huang H, et al. A reduced lymphocyte ratio as an early marker for predicting acute pancreatitis [J]. Sci Rep, 2017, 7: 44087.
9
Jeon TJ, Park JY. Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis [J]. World J Gastroenterol, 2017, 23(21): 3883-3889.
10
Nigro KG, O′Riordan M, Molloy EJ, et al. Performance of an automated immature granulocyte count as a predictor of neonatal sepsis [J]. Am J Clin Pathol, 2005, 123(4): 618-624.
11
Zhu Y. Tumor necrosis factor-α and procalcitonin level variations in the serum and their effects on organ function in patients with severe acute pancreatitis during infected stage [J]. Pak J Pharm Sci, 2017, 30(4Suppl): 1413-1416.
12
Uhlar CM, Whitehead AS. Serum amyloid A, the major vertebrate acute-phase reactant [J]. Eur J Biochem, 1999, 265(2): 501-523.
13
Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states [J]. Curr Opin Hematol, 2000, 7(1): 64-69.
14
曹永献, 孙桂荣, 孙秀芳. 联合检测血清淀粉样蛋白A和C-反应蛋白对重症急性胰腺炎早期预测的临床意义 [J]. 临床内科杂志, 2008, 25(8): 553-554.
15
谷小玉, 黄尚书, 梁伟新, 等. SAA、NLR预测急性胰腺炎严重程度的价值 [J]. 中国医药导报, 2018, 15(16): 63-66.
16
Holwerda DA. Glycopeptide from the posterior lobe of pig pituitaries. isolation and characterization [J]. Eur J Biochem, 1972, 28(3): 334-339.
17
Urwyler SA, Schuetz P, Sailer C, et al. Copeptin as a stress marker prior and after a written examination--the CoEXAM study [J]. Stress, 2015, 18(1): 134-137.
18
Fenske W, Refardt J, Chifu I, et al. A copeptin-based approach in the diagnosis of diabetes insipidus [J]. N Engl J Med, 2018, 379(5): 428-439.
19
Lee JH, Chan YH, Lai OF, et al. Vasopressin and copeptin levels in children with sepsis and septic shock [J]. Intensive Care Med, 2013, 39(4): 747-53.
20
Staubli SM, Oertli D, Nebiker CA. Laboratory markers predicting severity of acute pancreatitis [J]. Crit Rev Clin Lab Sci, 2015, 52(6): 273-283.
21
Sang G, Du JM, Chen YY, et al. Plasma copeptin levels are associated with prognosis of severe acute pancreatitis [J]. Peptides, 2014, 51: 4-8.
22
Isman FK, Zulfikaroglu B, Isbilen B, et al. Copeptin is a predictive biomarker of severity in acute pancreatitis [J]. Am J Emerg Med, 2013, 31(4): 690-692.
23
Sendler M, Weiss FU, Golchert J, et al. Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice [J]. Gastroenterology, 2017, 154(3): 704-718.
24
Talukdar R, Sareen A, Zhu H, et al. Release of cathepsin-B in cytosol causes cell death in acute pancreatitis [J]. Gastroenterology, 2016, 151(4): 747-758. e5.
25
Gabrilovich D, Nefedova Y. ROR1C regulates differentiation of myeloid-derived suppressor cells [J]. Cancer Cell, 2015, 28(2): 147-149.
26
Movahedi K, Guilliams M, Van den Bossche J, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity [J]. Blood, 2008, 111(8): 4233-4244.
27
Uhel F, Azzaoui I, Grégoire M, et al. Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in patients with sepsis [J]. Am J Respir Crit Care Med, 2017, 196(3): 315-327.
28
Samir M, Vaas LA, Pessler F. MicroRNAs in the host response to viral infections of veterinary importance [J]. Front Vet Sci, 2016, 3: 86.
29
Wei Q, Sun H, Song S, et al. MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury [J]. J Clin Invest, 2018, 128(12): 5448-5464.
30
Braunwald E. The war against heart failure: the Lancet lecture [J]. Lancet, 2015, 385(9970): 812-824.
31
Patel M, Verma A, Aslam I, et al. Novel plasma microRNA biomarkers for the identifi cation of colitis-associated carcinoma [J]. Lancet, 2015, 385(Suppl1): S78.
32
Kuśnierz-Cabala B, Nowak E, Sporek M, et al. Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis [J]. Pancreatology, 2015, 15(4): 344-351.
33
Liu S, Zou H, Wang Y, et al. miR-155-5p is negatively associated with acute pancreatitis and inversely regulates pancreatic acinar cell progression by targeting Rela and Traf3 [J]. Cell Physiol Biochem, 2018, 51(4): 1584-1599.
34
Song L, Wörmann S, Ai J, et al. BCL3 reduces the sterile inflammatory response in pancreatic and biliary tissues [J]. Gastroenterology, 2016, 150(2): 499-512.e20.
35
Criddle DN. Reactive oxygen species, Ca2+ stores and acute pancreatitis; a step closer to therapy? [J]. Cell Calcium, 2016, 60(3): 180-189.
36
Manohar M, Verma AK, Venkateshaiah SU, et al. Pathogenic mechanisms of pancreatitis [J]. World J Gastrointest Pharmacol Ther, 2017, 8(1): 10-25.
37
Pan MG, Xiong Y, Chen F. Nfat gene family in inflammation and cancer [J]. Curr Mol Med, 2013, 13(4): 543-554.
38
Norberg KJ, Nania S, Li X, et al. RCAN1 is a marker of oxidative stress, induced in acute pancreatitis [J]. Pancreatology, 2018, 18(7): 734-741.
[1] 张秋彬, 张楠, 林清婷, 徐军, 朱华栋, 姜辉. 急性胰腺炎合并急性肾损伤患者的预后评估[J]. 中华危重症医学杂志(电子版), 2023, 16(05): 382-389.
[2] 罗丹, 孔为民, 陈姝宁, 赵小玲, 谢云凯. 子宫内膜异位症患者在位及异位内膜上皮细胞-间充质转化相关生物标志物的变化[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 530-539.
[3] 代雯荣, 赵丽娟, 李智慧. 细胞外囊泡对胚胎着床影响的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 616-620.
[4] 李越洲, 张孔玺, 李小红, 商中华. 基于生物信息学分析胃癌中PUM的预后意义[J]. 中华普通外科学文献(电子版), 2023, 17(06): 426-432.
[5] 黄翠君, 张喜玲, 刘思嘉, 刘云建. 重症急性胰腺炎营养支持治疗研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(05): 385-390.
[6] 杜静怡, 徐兴祥. 循环肿瘤细胞在非小细胞肺癌中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 596-600.
[7] 陈安, 冯娟, 杨振宇, 杜锡林, 柏强善, 阴继凯, 臧莉, 鲁建国. 基于生物信息学分析CCN4在肝细胞癌中表达及其临床意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 702-707.
[8] 王小红, 钱晶, 翁文俊, 周国雄, 朱顺星, 祁小鸣, 刘春, 王萍, 沈伟, 程睿智, 秦璟灏. 巯基丙酮酸硫基转移酶调控核因子κB信号介导自噬对重症急性胰腺炎大鼠的影响及机制[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 422-426.
[9] 陆萍, 邹健. 凝血和纤维蛋白溶解标志物的动态变化对急性胰腺炎患者预后的评估价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 427-432.
[10] 吉茜茜, 田尧, 马林, 钱进. 红细胞分布宽度-白蛋白比值联合BISAP评分对急性胰腺炎严重程度及死亡率的预测价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 433-438.
[11] 黄岩, 刘晓巍, 杨春玲, 兰烨. 急性胰腺炎合并糖尿病患者的临床特征及血糖代谢与病情严重度的相关性[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 439-442.
[12] 马强, 李军, 苟丽娟. 重症急性胰腺炎miR-21-3p、RUNX3表达水平及对病情发展程度的预测[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 337-341.
[13] 孙旻. 血液淀粉酶、C反应蛋白、降钙素原及乳酸脱氢酶在急性胰腺炎患者病情评价及预后预测中的价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 331-336.
[14] 吴蓉菊, 向平超. COPD频繁急性加重表型与炎性因子相关性研究[J]. 中华临床医师杂志(电子版), 2023, 17(9): 939-947.
[15] 郭芳芳, 李珉珉. 狼疮肾炎无创生物标志物的研究进展[J]. 中华诊断学电子杂志, 2023, 11(04): 271-275.
阅读次数
全文


摘要