切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2020, Vol. 06 ›› Issue (02) : 128 -131. doi: 10.3877/cma.j.issn.2096-1537.2020.02.004

所属专题: 重症医学 文献

专题笔谈

脓毒症性心肌病的血管活性药物选择
刘一娜1, 马晓春1,()   
  1. 1. 110001 辽宁沈阳,中国医科大学附属第一医院重症医学科
  • 收稿日期:2019-12-24 出版日期:2020-05-28
  • 通信作者: 马晓春

Selection of vasoactive agents in septic cardiomyopathy

Yina Liu1, Xiaochun Ma1,()   

  1. 1. Department of Critical Care Medicine, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2019-12-24 Published:2020-05-28
  • Corresponding author: Xiaochun Ma
  • About author:
    Corresponding author: Ma Xiaochun, Email:
引用本文:

刘一娜, 马晓春. 脓毒症性心肌病的血管活性药物选择[J/OL]. 中华重症医学电子杂志, 2020, 06(02): 128-131.

Yina Liu, Xiaochun Ma. Selection of vasoactive agents in septic cardiomyopathy[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(02): 128-131.

脓毒症性心肌病是脓毒症导致的急性心功能障碍综合征,与冠状动脉阻塞所致缺血无明显关联,其以心室扩张、心肌收缩减弱、心功能损害具有可逆性为特征,诊断和治疗措施尚不明确。一般认为脓毒症性心肌病的治疗策略与未合并心肌病的脓毒症并无明显不同,血管活性药物的选择可参照脓毒症、感染性休克的临床研究及指南推荐意见实施,个体化治疗策略还有待高质量的临床研究数据提供。

Septic cardiomyopathy is an acute syndrome of cardiac dysfunction that is unrelated to cardiac ischemia in patients with sepsis. It is characterized by ventricular dilation, myocardial contraction weakening, and reversible cardiac dysfunction. There have been no standards for the diagnosis and therapy of septic cardiomyopathy, and the treatment strategy currently used for septic cardiomyopathy is the same as that for sepsis without cardiomyopathy. When selecting vasoactive agents, the recommendations from sepsis guidelines should be taken into account. Further clinical research of individualized treatment for septic cardiomyopathy is necessary.

1
Beesley SJ, Weber G, Sarge T, et al. Septic Cardiomyopathy. Critical care medicine [J]. 2018, 46(4): 625-634.
2
Sato R, Kuriyama A, Takada T, et al. Prevalence and risk factors of sepsis-induced cardiomyopathy: A retrospective cohort study[J]. Medicine, 2016, 95(39): e5031.
3
Jeong HS, Lee TH, Bang CH, et al. Risk factors and outcomes of sepsis-induced myocardial dysfunction and stress-induced cardiomyopathy in sepsis or septic shock: A comparative retrospective study[J]. Medicine, 2018, 97(13): e0263.
4
Vieillard-Baron A, Caille V, Charron C, et al. Actual incidence of global left ventricular hypokinesia in adult septic shock[J]. Critical Care Medicine, 2008, 36(6): 1701-1706.
5
Kakihana Y, Ito T, Nakahara M, et al. Sepsis-induced myocardial dysfunction: pathophysiology and management[J]. J Intensive Care. 2016, 4: 22.
6
Huang SJ, Nalos M, McLean AS. Is early ventricular dysfunction or dilatation associated with lower mortality rate in adult severe sepsis and septic shock? A meta-analysis[J]. Critical Care, 2013, 17(3): R96.
7
Sato R, Nasu M. A review of sepsis-induced cardiomyopathy[J]. J Intensive Care, 2015, 3: 48.
8
Sweeney TE, Khatri P. Septic cardiomyopathy: getting to the heart of the matter[J]. Crit Care Med, 2017, 45(3): 556-557.
9
Sanfilippo F, Orde S, Oliveri F, et al. The challenging diagnosis of septic cardiomyopathy. Chest [J]. 2019, 156(3): 635-636.
10
Martin L, Derwall M, Al Zoubi S, et al. The septic heart: current understanding of molecular mechanisms and clinical implications[J]. Chest, 2019, 155(2): 427-437.
11
Ghadri JR, Wittstein IS, Prasad A, et al. International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management[J]. EurHeart J, 2018, 39(22): 2047-2062.
12
De Backer D, Pinsky M. Norepinephrine improves cardiac function during septic shock, but why?[J]. British Journal of Anaesthesia, 2018, 120(3): 421-424.
13
Hamzaoui O, Jozwiak M, Geffriaud T, et al. Norepinephrine exerts an inotropic effect during the early phase of human septic shock. British journal of anaesthesia [J]. 2018, 120(3): 517-524.
14
Annane D, Ouanes-Besbes L, de Backer D, et al. A global perspective on vasoactive agents in shock[J]. Intensive care medicine, 2018, 44(6): 833-846.
15
Rachoin JS, Dellinger RP. Timing of norepinephrine in septic patients: NOT too little too late[J]. Critical Care, 2014, 18(6):691.
16
Wilkman E, Kaukonen KM, Pettila V, etal. Association between inotrope treatment and 90-day mortality in patients with septic shock[J]. Acta Anaesthesiol Scand, 2013, 57(4): 431-442.
17
Sato R, Nasu M. Time to re-think the use of dobutamine in sepsis[J]. J Intensive Care. 2017, 5: 65.
18
Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016[J]. Intensive Care Medicine, 2017, 43(3): 304-377.
19
Nishida O, Ogura H, Egi M, et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)[J]. J Intensive Care, 2018, 6: 7.
20
Zausig YA, Geilfus D, Missler G, et al. Direct cardiac effects of dobutamine, dopamine, epinephrine, and levosimendan in isolated septic rat hearts[J]. Shock, 2010, 34(3): 269-274.
21
Annane D, Vignon P, Renault A, et al. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial[J]. Lancet, 2007, 370(9588): 676-684.
22
Colling KP, Banton KL, Beilman GJ. Vasopressors in sepsis[J]. Surgical Infections, 2018, 19(2): 202-207.
23
Mahmoud KM, Ammar AS. Norepinephrine supplemented with dobutamine or epinephrine for the cardiovascular support of patients with septic shock[J]. Indian J Crit Care Med, 2012,16(2): 75-80.
24
Levy B. Lactate and shock state: the metabolic view[J]. Curr Opin Crit Care, 2006, 12(4): 315-321.
25
Levy B, Dusang B, Annane D, et al. Cardiovascular response to dopamine and early prediction of outcome in septic shock: a prospective multiple-center study[J]. Crit Care Med, 2005, 33(10): 2172-2177.
26
Treschan TA, Peters J. The vasopressin system: physiology and clinical strategies[J]. Anesthesiology, 2006, 105(3): 599-612; quiz 39-40.
27
Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock[J]. N Engl J Med, 2008, 358(9): 877-887.
28
Mehta S, Granton J, Gordon AC, et al. Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine[J]. Critical Care, 2013, 17(3): R117.
29
29Wasilewski MA, Grisanti LA, Song J, et al. Vasopressin type 1A receptor deletion enhances cardiac contractility, beta-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction[J]. Clin Sci (Lond), 2016, 130(22): 2017-2027.
30
Radermacher P, Huber-Lang M, Thiemermann C. Catecholamines and the septic heart: opening Pandora′s box?[J]. Shock, 2013, 39(4): 404-405.
31
Tan K, Harazim M, Tang B, et al. The association between premorbid beta blocker exposure and mortality in sepsis-a systematic review[J]. Critical Care, 2019, 23(1): 298.
32
Morelli A, Ertmer C, Westphal M, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial[J]. Jama, 2013, 310(16): 1683-1691.
33
Du W, Wang XT, Long Y, etal. Efficacy and Safety of Esmolol in Treatment of Patients with Septic Shock[J]. Chin Med J (Engl), 2016, 129(14): 1658-1665.
34
Morelli A, Donati A, Ertmer C, et al. Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study[J]. Critical Care Medicine, 2013, 41(9): 2162-2168.
35
Ehrman RR, Sullivan AN, Favot MJ, et al. Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature[J]. Critical Care, 2018, 22(1): 112.
[1] 庄燕, 戴林峰, 张海东, 陈秋华, 聂清芳. 脓毒症患者早期生存影响因素及Cox 风险预测模型构建[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 372-378.
[2] 杨瑾, 刘雪克, 张媛媛, 金钧, 韦瑶. 肠道微生物来源石胆酸对脓毒症相关肝损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 265-274.
[3] 张霞, 张瑞, 郑志波, 张勤. 紫草素调控乳酸化修饰和线粒体功能改善脓毒症心肌病小鼠的预后[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 275-284.
[4] 张婧琦, 江洋, 孙佳璐, 唐兴喆, 赵宇飞, 崔颖, 李信响, 戴景月, 傅琳, 彭新桂. 基于肾周CT特征结合血清肌酐水平探讨脓毒症伴急性肾损伤的早期识别[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 285-292.
[5] 李振翮, 魏长青, 甄国栋, 李振富. 脓毒症并发急性呼吸窘迫综合征患者血清S1P、Wnt5a变化及其临床意义[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 293-300.
[6] 樊恒, 孙敏, 朱建华. 红景天苷通过抑制PI3K/AKT/mTOR信号通路对大鼠脓毒症急性肾损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(03): 188-195.
[7] 陈曦, 吴宗盛, 郑明珠, 邱海波. 胸腺萎缩在脓毒症免疫紊乱中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 379-383.
[8] 杨翔, 郭兰骐, 谢剑锋, 邱海波. 转录组学在脓毒症诊疗中的临床研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 384-388.
[9] 成人脓毒症患者β-内酰胺类抗生素延长输注专家共识编写组. 成人脓毒症患者β-内酰胺类抗生素延长输注专家共识[J/OL]. 中华重症医学电子杂志, 2024, 10(04): 313-324.
[10] 胡梓菡, 彭菲, 孙骎, 杨毅. 细胞外囊泡在脓毒症血管内皮损伤作用中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 265-270.
[11] 刘娟丽, 马四清, 乌仁塔娜. 髓源性抑制细胞在脓毒症中的研究进展[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 271-278.
[12] 苏生林, 马金兰, 于弘明, 杨晓军. 单细胞测序技术在脓毒症免疫研究中的应用进展[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 279-286.
[13] 陈惠英, 邱敏珊, 邵汉权. 脓毒症诱发肠黏膜屏障功能损伤的风险因素模型构建与应用效果[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 448-452.
[14] 傅新露, 李之岳, 卢丹. 妊娠合并结肠癌穿孔致脓毒症休克一例并文献复习[J/OL]. 中华产科急救电子杂志, 2024, 13(04): 227-231.
[15] 席静妮, 李娜, 张琪. 中性粒细胞与淋巴细胞比值对老年重症社区获得性肺炎进展为脓毒症的预测价值[J/OL]. 中华老年病研究电子杂志, 2024, 11(03): 28-31.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?