切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2020, Vol. 06 ›› Issue (03) : 244 -247. doi: 10.3877/cma.j.issn.2096-1537.2020.03.002

所属专题: 重症医学 文献

专家论坛

体外膜氧合辅助:需要关注神经功能
侯晓彤1,(), 王红1   
  1. 1. 100029 首都医科大学附属北京安贞医院心脏外科危重症中心
  • 收稿日期:2019-12-14 出版日期:2020-08-28
  • 通信作者: 侯晓彤

Neurological function changes during extracorporeal membrane oxygenation support

Xiaotong Hou1,(), Hong Wang1   

  1. 1. Critical Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
  • Received:2019-12-14 Published:2020-08-28
  • Corresponding author: Xiaotong Hou
  • About author:
    Corresponding author: Hou Xiaotong, Email:
引用本文:

侯晓彤, 王红. 体外膜氧合辅助:需要关注神经功能[J/OL]. 中华重症医学电子杂志, 2020, 06(03): 244-247.

Xiaotong Hou, Hong Wang. Neurological function changes during extracorporeal membrane oxygenation support[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(03): 244-247.

对于体外膜氧合(ECMO)辅助患者的神经功能改变,目前的认知还远远不足,前瞻性研究的难度也非常大。脑梗死、脑出血等的诊断需要依靠特殊的辅助检查,如果只对少部分患者进行这些检查,诊断率和实际发生率之间就会具有较大差异。从应对神经系统并发症的方法看,目前尚无针对ECMO辅助患者神经系统并发症的特异性治疗手段。当前阶段,对ECMO辅助患者神经系统并发症的预防大于治疗,需要充分理解ECMO造成的病理生理改变,对有ECMO适应证的患者及早进行辅助治疗,在ECMO转机中做好每一个细节,加强监测,及时撤机。

The understanding of neurological function changes caused by extracorporeal membrane oxygenation (ECMO) is far from enough, and the prospective research in this field is very difficult. The diagnosis of cerebral infarction and cerebral hemorrhage depends on special examinations. Because only a small number of patients have undergone these examinations, there is a big difference between the diagnosis rate and the actual incidence rate. Moreover, there is no specific treatment for patients assisted with ECMO who suffered nervous system complications. At present, the prevention of nervous system complications is more important than the treatment. It is necessary to fully understand the pathophysiological changes caused by ECMO, give prompt assistance to patients with ECMO indications, and pay attention to details in every ECMO run, enhancement of monitoring and withdrawing ECMO in time are also helpful.

表1 ECMO时神经系统损害的危险因素[8]
表2 ECMO患者影像学检查的适应证和各种检查的局限性[8]
1
侯晓彤, 李呈龙, 江瑜. 2017中国体外生命支持情况调查分析[J]. 中华医学杂志, 2018, 98: 3603-3606.
2
李呈龙, 侯晓彤, 黑飞龙, 等. 2018中国体外生命支持情况调查分析[J]. 中华医学杂志, 2019, 99: 1911-1915.
3
Lorusso R, Barili F, Mauro MD, et al. In-hospital neurologic complications in adult patients undergoing venoarterial extracorporeal membrane oxygenation: results from the extracorporeal life support organization registry [J]. Crit Care Med, 2016, 44(10): e964.
4
Hervey-Jumper SL, Annich GM, Yancon AR, et al. Neurological complications of extracorporeal membrane oxygenation in children [J]. J Neurosurg Pediatr, 2011, 7: 338-344.
5
Cho SM, Farrokh S, Whitman G, et al. Neurocritical care for extracorporeal membrane oxygenation patients [J]. Crit Care Med, 2019, 47: 1773-1781.
6
Risnes I, Wagner K, Nome T, et al. Cerebral outcome in adult patients treated with extracorporeal membrane oxygenation [J]. Ann Thorac Surg, 2006, 81: 1401-1406.
7
Sutter R, Tisljar K, Marsch S. Acute neurologic complications during extracorporeal membrane oxygenation: a systematic review [J]. Crit Care Med, 2018, 46(9): 1506-1513.
8
Xie A, Lo P, Yan TD, et al. Neurologic complications of extracorporeal membrane oxygenation: a review [J]. J Cardiothorac Vasc Anesth, 2017, 31(5): 1836-1846.
9
Ryu JA, Chung CR, Cho YH, et al. Neurologic outcomes in patients who undergo extracorporeal cardiopulmonary resuscitation [J]. Ann Thorac Surg, 2019, 108(3): 749-755.
10
Le Guennec L, Cholet C, Huang F, et al. Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation [J]. Ann Intensive Care, 2018, 8(1): 129.
11
Chalegre ST, Sá MP, de Rueda FG, et al. Central versus peripheral arterial cannulation and neurological outcomes after thoracic aortic surgery: meta-analysis and meta-regression of 4459 patients [J]. Perfusion, 2015, 30(5): 383-388.
12
Luyt CE, Brechot N, Demondion P, et al. Brain injury during venovenous extracorporeal membrane oxygenation [J]. Intensive Care Med, 2016, 42: 897-907.
13
Yang F, jia ZS, Xing JL, et al. Effects of intra-aortic balloon pump on cerebral blood flow during peripheral venoarterial extracorporeal membrane oxygenation support [J]. J Transl Med, 2014, 12: 106.
14
Samadi B1, Nguyen D, Rudham S, et al. Spinal cord infarct during concomitant circulatory support with intra-aortic balloon pump and veno-arterial extracorporeal membrane oxygenation [J]. Crit Care Med, 2016, 44(2): e101.
15
ECLS. Ecls registry report international summary January, 2019[2019-12-11].

URL    
16
Okochi S, Shakoor A, Barton S, et al. Prevalence of seizures in pediatric extracorporeal membrane oxygenation patients as measured by continuous electroencephalography [J]. Pediatr Crit Care Med, 2018, 19(12): 1162-1167.
17
Wong JK, Smith TN, Pitcher HT, et al. Cerebral and lower limb near-infrared spectroscopy in adults on extracorporeal membrane oxygenation [J]. Artif Organs, 2012, 36(8): 659-667.
18
Cho SM, Ziai W, Mayasi Y, et al. Noninvasive neurological monitoring in extracorporeal membrane oxygenation [J]. ASAIO J, 2020, 66(4): 388-393.
19
Krenzlin H, Rosenthal C, Wolf S, et al. Surgical treatment of intraparenchymal hemorrhage during mechanical circulatory support for heartfailure - A single-centre experience [J]. Acta Neurochir (Wien), 2014, 156: 1729-1734.
20
Madderom MJ, Schiller RM, Gischler SJ, et al. Growing up after critical illness: verbal, visual-spatial, and working memory problems in neonatal extracorporeal membrane oxygenation survivors [J]. Crit Care Med, 2016, 44(6): 1182-1190.
[1] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[2] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[3] 赵丽霞, 王春霞, 陈一锋, 胡东平, 张维胜, 王涛, 张洪来. 内脏型肥胖对腹腔镜直肠癌根治术后早期并发症的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 35-39.
[4] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[5] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[6] 徐逸男. 不同术式治疗梗阻性左半结直肠癌的疗效观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 72-75.
[7] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[8] 许杰, 李亚俊, 冯义文. SOX新辅助化疗后腹腔镜胃癌D2根治术与常规根治术治疗进展期胃癌的近期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 647-650.
[9] 康婵娟, 张海涛, 翟静洁. 胰管支架置入术治疗急性胆源性胰腺炎的效果及对患者肝功能、炎症因子水平的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 667-670.
[10] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[11] 刘柏隆, 周祥福. 女性尿失禁吊带手术并发症处理的经验分享[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 127-127.
[12] 嵇振岭, 陈杰, 唐健雄. 重视复杂腹壁疝手术并发症的预防和处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 601-606.
[13] 江志鹏, 钟克力, 陈双. 复杂腹壁疝手术后腹腔高压与腹腔间室综合征的预防和处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 612-615.
[14] 王学虎, 赵渝. 复杂腹壁疝手术中血管损伤并发症的预防和处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 616-619.
[15] 石阳, 于剑锋, 曹可, 翟志伟, 叶春祥, 王振军, 韩加刚. 可扩张金属支架置入联合新辅助化疗治疗完全梗阻性左半结肠癌围手术期并发症分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 464-471.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?