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中华重症医学电子杂志 ›› 2020, Vol. 06 ›› Issue (01) : 104 -108. doi: 10.3877/cma.j.issn.2096-1537.2020.031

所属专题: 文献

综述

维生素C在脓毒症中的应用进展
吕清泉1, 顾小花1, 吕应鸣2, 郑瑞强1,()   
  1. 1. 225000 扬州,江苏省苏北人民医院重症医学科
    2. 225700 江苏省兴化市德美康复医院普外科
  • 收稿日期:2019-03-22 出版日期:2020-02-28
  • 通信作者: 郑瑞强

Application of vitamin C in sepsis

Qingquan Lyu1, Xiaohua Gu1, Yingming Lyu2, Ruiqiang Zheng1,()   

  1. 1. Department of Critical Care Medicine, Northern Jiangsu People′s Hospital, Clinical Medical College, Yangzhou University, Yangzhou 225000, China
    2. Department of General Surgery, Demei Rehabilitation Hospital, Xinghua 225700, China
  • Received:2019-03-22 Published:2020-02-28
  • Corresponding author: Ruiqiang Zheng
  • About author:
    Corresponding author: Zheng Ruiqiang, Email:
引用本文:

吕清泉, 顾小花, 吕应鸣, 郑瑞强. 维生素C在脓毒症中的应用进展[J/OL]. 中华重症医学电子杂志, 2020, 06(01): 104-108.

Qingquan Lyu, Xiaohua Gu, Yingming Lyu, Ruiqiang Zheng. Application of vitamin C in sepsis[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(01): 104-108.

脓毒症是重症患者发病和死亡的主要原因。由于氧化应激时代谢消耗增加以及脱氢抗坏血酸再循环减少等原因,脓毒症患者常合并维生素C减少或缺乏。外源性补充维生素C,可能是脓毒症有效的辅助治疗措施。本文就维生素C在脓毒症中应用的作用机制、用法用量、潜在副作用、联合疗法及目前开展的临床研究等方面进行综述,旨在深化临床医师对维生素C在脓毒症治疗中的作用的认识。

Sepsis is a leading cause of morbidity and mortality in critically ill patients. Most patients with sepsis had hypovitaminosis C or vitamin C deficiency, which probably caused by increased metabolic consumption due to critically illness-induced oxidative stress and reduced recycling of dehydroascorbic acid. Therefore, repletion of vitamin C may be an effective adjuvant therapy in sepsis. We review the mechanism, dosage and usage, potential side effects, combination with others and the current clinical researches of vitamin C in sepsis management, to deepen the clinicians′ understanding the role of vitamin C in sepsis treatment.

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