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中华重症医学电子杂志

中华重症医学电子杂志 ›› 2022, Vol. 08 ›› Issue (02) : 167 -172. doi: 10.3877/cma.j.issn.2096-1537.2022.02.013

综述

肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展
刘娟丽1, 马四清2,†(), 陈强2   
  1. 1. 810007　西宁，青海省人民医院重症医学科；810001　西宁，青海大学高原医学研究中心
    2. 810007　西宁，青海省人民医院重症医学科
  • 收稿日期:2022-02-16 出版日期:2022-07-04
  • 通信作者: 马四清
  • 基金资助:
    国家自然科学基金项目(81860351); 青海省高原重症医学重点实验室项目(2020-81); 青海省高原医学应用基础重点实验室（青海-犹他高原医学联合重点实验室）项目(2022-ZJ-Y15)

Research progress on the function of surfactant protein -D and its role in the common lung diseases

Juanli Liu1, Siqing Ma2,†(), Qiang Chen2   

  1. 1. Department of Critical Care Medicine, Qinghai Provincial People′s Hospital, Xining 810007, China; Plateau Medical Center of Qinghai University, Xining 810001, China
    2. Department of Critical Care Medicine, Qinghai Provincial People′s Hospital, Xining 810007, China
  • Received:2022-02-16 Published:2022-07-04
  • Corresponding author: Siqing Ma
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刘娟丽, 马四清, 陈强. 肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展[J]. 中华重症医学电子杂志, 2022, 08(02): 167-172.

Juanli Liu, Siqing Ma, Qiang Chen. Research progress on the function of surfactant protein -D and its role in the common lung diseases[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(02): 167-172.

肺表面活性蛋白-D（SP-D）是凝集素家族糖蛋白，主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌，储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一，也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面活性剂池稳态外，还具有宿主防御和免疫调节功能。本文通过对近年来SP-D在肺部常见疾病中的部分相关研究进行总结，为众多肺部疾病，特别是肺部炎症性疾病潜在的治疗提供重要的方法理论基础。

关键词: 表面活性蛋白-D, 表面活性剂池稳态, 宿主防御, 免疫调节

Lung surfactant protein D (SP-D) is a glycoprotein of the lectin family. In lungs it is synthesized and secreted mainly in the alveolar type Ⅱ epithelial cells and non-ciliated bronchiole epithelial cells, and are stored in secretory granules of Clara cells. SP-D is one of the surfactant binding proteins and is also a part of the pulmonary surfactant system. In addition to contributing to the homeostasis of surfactant pools in alveolar space, SP-D also exhibits functions of host defense and immunoregulation. This paper summarizes some relevant studies on SP-D in acute lung diseases in recent years, providing important theoretical basis for the potential treatment of many lung diseases, especially in inflammatory lung diseases.

Key words: Surfactant proteins D, Homeostasis of surfactant pools, Host defense, Immune regulation
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