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中华重症医学电子杂志 doi: 10.3877/cma.j.issn.2096-1537.2024.07.29-0003

所属专题: 有“依”可靠-全国MDR诊疗实践项目——优秀病例展示

依拉环素治疗多重耐药鲍曼不动杆菌重症肺炎一例
张群1, 王明月1, 何梦钰1, 戴山林1, 孙文逵1,()   
  1. 1. 210029 南京,南京医科大学第一附属医院呼吸与危重症医学科
  • 收稿日期:2023-12-06
  • 通信作者: 孙文逵
  • 基金资助:
    中国博士后面上项目(2020M671396); 江苏省博士后面上项目(2020Z239)

Treatment of severe pneumonia caused by multidrug-resistant Acinetobacter baumannii with Eravacycline: a case report

Qun Zhang1, Mingyue Wang1, Mengyu He1, Shanshan Dai1, Wenkui Sun1,()   

  1. 1. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2023-12-06
  • Corresponding author: Wenkui Sun
引用本文:

张群, 王明月, 何梦钰, 戴山林, 孙文逵. 依拉环素治疗多重耐药鲍曼不动杆菌重症肺炎一例[J]. 中华重症医学电子杂志, doi: 10.3877/cma.j.issn.2096-1537.2024.07.29-0003.

Qun Zhang, Mingyue Wang, Mengyu He, Shanshan Dai, Wenkui Sun. Treatment of severe pneumonia caused by multidrug-resistant Acinetobacter baumannii with Eravacycline: a case report[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), doi: 10.3877/cma.j.issn.2096-1537.2024.07.29-0003.

本例为多重耐药鲍曼不动杆菌引起肺部感染的患者,当地医院予比阿培南联合莫西沙星抗感染,病情未见明显好转,持续出现发热症状。转入我科后予头孢哌酮舒巴坦联合替加环素治疗,患者体温恢复正常,但出现了替加环素相关的严重不良反应,包括血小板(Plt)减少、凝血功能异常和出血症状。停用替加环素后改用依拉环素抗感染,Plt逐渐恢复,凝血功能也逐渐改善,最终患者好转出院。

This case report describes a patient with pulmonary infection caused by multidrug-resistant Acinetobacter baumannii. The patient was initially treated with a combination of Biapenem and Moxifloxacin at a local hospital, but there was no significant improvement in their condition, and they continued to experience fever symptoms. After transfer to our department, the patient was treated with Cefoperazone-Sulbactam in combination with Tigecycline. The patient's body temperature returned to normal, but they developed severe adverse reactions attributed to Tigecycline, including thrombocytopenia, coagulation abnormalities, and bleeding symptoms. Tigecycline was discontinued, and the patient was switched to treatment with Eravacycline, which resulted in a gradual recovery of platelet count and improvement in coagulation function. Eventually, the patient recovered and was discharged.

图1 2023年7月20日患者胸部CT肺窗影像。图a为主动脉弓层面肺窗;图b为主肺动脉窗层面;图c为气管分叉层面;图d为右肺动脉层面
图2 患者入院后体温、Plt、Hb、Fib、APTT/PT的动态变化。图a为体温;图b为Plt/Hb;图c为Fib;图d为APTT/PT 注:Plt为血小板;Hb血红蛋白;Fib纤维蛋白原;APTT为活化部分凝血酶原时间;PT为凝血酶原时间
图3 2023年8月4日患者胸部CT肺窗影像。图a为主动脉弓层面肺窗;图b为主肺动脉窗层面;图c为气管分叉层面;图d为右肺动脉层面
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