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中华重症医学电子杂志 ›› 2026, Vol. 12 ›› Issue (02) : 196 -201. doi: 10.3877/cma.j.issn.2096-1537.2026.02.017

综述

宿主反应识别脓毒症致病病原体的研究进展
杨翔1,2, 郭兰骐1, 谢剑锋1,(), 邱海波1   
  1. 1 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
    2 210002 南京,解放军东部战区总医院干部病房一科
  • 收稿日期:2024-07-09 出版日期:2026-05-28
  • 通信作者: 谢剑锋
  • 基金资助:
    国家自然科学基金项目(82272210,82341032); 国家重点研发计划项目(2021YFC2500804); 江苏省重症医学重点实验室项目(BM2020004)

Research progress of host response recognition of sepsis-causing pathogens

Xiang Yang1,2, Lanqi Guo1, Jianfeng Xie1,(), Haibo Qiu1   

  1. 1 Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
    2 First Department of Geriatrics, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, China
  • Received:2024-07-09 Published:2026-05-28
  • Corresponding author: Jianfeng Xie
引用本文:

杨翔, 郭兰骐, 谢剑锋, 邱海波. 宿主反应识别脓毒症致病病原体的研究进展[J/OL]. 中华重症医学电子杂志, 2026, 12(02): 196-201.

Xiang Yang, Lanqi Guo, Jianfeng Xie, Haibo Qiu. Research progress of host response recognition of sepsis-causing pathogens[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2026, 12(02): 196-201.

脓毒症是因感染导致宿主反应失控,进而发展为威胁生命的器官功能障碍的临床综合征。早期给予适当的抗菌药物治疗是脓毒症患者救治的核心措施。当前临床应用的病原学诊断方法无法在准确性及时效性上满足脓毒症早期识别致病病原体的需要。近年来,通过区分不同致病病原体间差异性的宿主反应来早期识别脓毒症的致病病原体并指导精准治疗取得了一些突破性进展,有望构建脓毒症诊断和治疗的新体系。本文针对宿主反应导向的病原体识别进行综述,旨在明确宿主反应在识别脓毒症致病病原体方面的研究进展,为临床医师脓毒症早期、精准抗感染方案的制定提供新的方法及思路。

Sepsis is a life-threatening clinical syndrome characterized by dysregulated host responses to infection, resulting in severe organ dysfunction. Although early and appropriate antimicrobial therapy remains the cornerstone of sepsis management, conventional diagnostic methods often fail to meet the clinical requirements for accuracy and timeliness in pathogen identification. Recent breakthroughs in pathogen identification through differential host immune responses offer a promising framework for a new diagnostic and therapeutic paradigm. This review summarizes progress in host-response-oriented pathogen identification, aiming to provide clinicians with innovative strategies for early, precise formulation of anti-infective regimens.

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