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中华重症医学电子杂志 ›› 2016, Vol. 02 ›› Issue (02) : 151 -158. doi: 10.3877/cma.j.jssn.2096-1537.2016.02.018

所属专题: 重症医学 文献

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全身性感染诱导心脏舒张功能障碍的探讨
韩建伟, 马朋林   
  • 收稿日期:2016-03-13 出版日期:2016-05-28
  • 通信作者: 马朋林

Sepsis-induced diastolic dysfunctionof heart

Jianwei Han, Penglin Ma   

  • Received:2016-03-13 Published:2016-05-28
  • Corresponding author: Penglin Ma
  • About author:
    Corresponding author: Ma Penglin, Email:
引用本文:

韩建伟, 马朋林. 全身性感染诱导心脏舒张功能障碍的探讨[J]. 中华重症医学电子杂志, 2016, 02(02): 151-158.

Jianwei Han, Penglin Ma. Sepsis-induced diastolic dysfunctionof heart[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2016, 02(02): 151-158.

近年来,随着床旁超声诊断的广泛开展,流行病学数据显示全身性感染诱导心脏舒张功能障碍并非是一种少见临床现象。并且不断增多的基础与临床研究资料提示肾上腺能应激增高、炎症损伤以及不恰当的容量复苏等因素与全身性感染诱导心脏舒张功能障碍密切相关。然而,到目前为止,确切的发生机制仍未被阐明,对一些可能的干预手段亦存在一定程度的争议,尚不足以形成共识或指南推荐意见。由此可见,全身性感染诱导心脏舒张功能障碍是当前临床重症医疗面临的困难问题之一,针对该领域的深入研究十分必要。

Recent studies using bedside ultrasound images have revealed that sepsis-induced cardiac diastolic dysfunction is a common clinical phenomenon. Increasing evidence suggests that excessive adrenergic stress, inflammatory injury and inadequate fluid resuscitation may all contribute to sepsis-induced cardiac diastolic dysfunction although the exact mechanisms remain unclear. The current approaches of clinical interventions are controversial making it difficult to reach a consensus for recommended guidelines. Further basic research and clinical investigation is urgently required to improve the management of sepsis-induced cardiac diastolic dysfunction in critically ill patients.

图1 二尖瓣血流检测法评估心脏舒张功能障碍
图2 二尖瓣血流检测结合组织多普勒对心脏舒张功能障碍的诊断及分级
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