单细胞测序技术在脓毒症免疫研究中的应用进展

苏生林; 马金兰; 于弘明; 杨晓军

doi:10.3877/cma.j.issn.2096-1537.2024.03.012

中华重症医学电子杂志 >

2024 , Vol. 10 >Issue 03: 279 - 286

DOI: https://doi.org/10.3877/cma.j.issn.2096-1537.2024.03.012

综述

单细胞测序技术在脓毒症免疫研究中的应用进展

苏生林 ¹ ,
马金兰 ² ,
于弘明 ¹ ,
杨晓军 ^,³^,^†

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^1.750004　银川，宁夏医科大学第一临床医学院
^2.750004　银川，宁夏医科大学总医院重症医学科
^3.750004　银川，宁夏医科大学第一临床医学院；750004　银川，宁夏医科大学总医院重症医学科

通信作者：杨晓军，Email：yxjicu@163.com

Copy editor: 卫轲

收稿日期: 2024-04-30

网络出版日期: 2024-09-06

基金资助

宁夏回族自治区重点研发计划项目(2023BEG02024)

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未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计，除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。本刊为电子期刊，以网刊形式出版。

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Application of single cell sequencing technology in the study of sepsis immunity

Shenglin Su ¹ ,
Jinlan Ma ² ,
Hongming Yu ¹ ,
Xiaojun Yang ^,³^,^†

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^1.The First Clinical Medical School of Ningxia Medical University, Yinchuan 750004, China
^2.Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, China
^3.The First Clinical Medical School of Ningxia Medical University, Yinchuan 750004, China; Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, China

Corresponding author: Yang Xiaojun, Email: yxjicu@163.com

Received date: 2024-04-30

Online published: 2024-09-06

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No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission.

All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.

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摘要

脓毒症（sepsis）是一种高病死率的临床综合征，尽管多学科方法不断发展和进步，脓毒症仍可发展为致命的器官衰竭。近年来单细胞测序技术的飞速发展，为脓毒症病理生理机制的探索提供了全新的技术支持，尤其在免疫学方面的应用使得脓毒症的精准防治成为可能。本综述通过回顾近年的相关研究，阐述脓毒症及脓毒症免疫抑制的发生发展，介绍单细胞测序技术在脓毒症及脓毒症免疫抑制研究中的应用进展，旨在探索未来使用单细胞测序技术在脓毒症精准化治疗方面应用的可能性。

关键词： 脓毒症; 单细胞RNA测序; 免疫抑制; 精准医疗

本文引用格式

苏生林 , 马金兰 , 于弘明 , 杨晓军 . 单细胞测序技术在脓毒症免疫研究中的应用进展[J]. 中华重症医学电子杂志, 2024 , 10(03) : 279 -286 . DOI: 10.3877/cma.j.issn.2096-1537.2024.03.012

Abstract

Sepsis is a clinical syndrome with a high mortality rate, and despite the development and advancement of multidisciplinary approaches, sepsis can progress to fatal organ failure. In recent years, the rapid development of single-cell sequencing technology has provided a new technical support for the exploration of the pathophysiological mechanism of sepsis, especially the application in immunology has made the precise prevention and treatment of sepsis possible. This review reviewed relevant studies in recent years, described the occurrence and development of sepsis and sepsis-induced immunosuppression, introduced the application progress of single cell sequencing technology in sepsis and sepsis-induced immunosuppression research, and aimed to explore the possibility of future application of single cell sequencing technology in the precision treatment of sepsis.

Key words： Sepsis; Single-cell RNA sequencing; Immunosuppression; Precision medicine

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