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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (02) : 94 -99. doi: 10.3877/cma.j.issn.2096-1537.2017.02.004

所属专题: 重症医学 文献

专题笔谈

移植供肝保护新进展
朱泽斌1, 赵强1, 何晓顺1,()   
  1. 1. 510080 广州,中山大学附属第一医院肝移植科
  • 收稿日期:2017-04-07 出版日期:2017-05-28
  • 通信作者: 何晓顺
  • 基金资助:
    国家自然科学基金(81170448,81471583); 公益性行业科研专项基金项目(201302009); 广东省器官捐献与移植免疫重点实验室建设项目(2013A061401007)

New progress in protection of donor liver

Zebin Zhu1, Qiang Zhao1, Xiaoshun He1,()   

  1. 1. Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2017-04-07 Published:2017-05-28
  • Corresponding author: Xiaoshun He
  • About author:
    Corresponding author: He Xiaoshun, Email:
引用本文:

朱泽斌, 赵强, 何晓顺. 移植供肝保护新进展[J]. 中华重症医学电子杂志, 2017, 03(02): 94-99.

Zebin Zhu, Qiang Zhao, Xiaoshun He. New progress in protection of donor liver[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(02): 94-99.

肝移植是治疗终末期肝病唯一有效的方法,随着肝移植技术的不断提高,适应证的不断扩大,术后预后的不断改善,等待肝移植的患者越来越多,因此移植界面临供体严重不足的问题。肝缺血再灌注损伤(IRI)严重制约"边缘"供肝的利用,最大限度减少供肝缺血再灌注损伤,对于提高肝移植治疗效果具有重要意义。目前,我国移植供器官的来源为公民逝世后器官捐献。由于器官保护技术直接影响供体器官的质量及受体移植后预后,因此器官保护在器官捐献工作中有着极其重要的地位。本文就肝缺血再灌注损伤发生机制,供肝质量评估,器官获取,肝保存和修复以及器官转运几个方面的最新研究进展进行综述。

Liver transplantation is the unique effective treatment for patients with end-stage liver disease. With the improvement of operative technique, expansion of indications and improvement of postoperative outcomes, there are an increasing number of patients in liver transplant waiting lists. Consequently, shortage of donors becomes a serious issue in the liver transplantation community. Liver ischemia reperfusion injury (IRI) seriously restricts the utilizing of marginal donor liver, so minimizing liver ischemia reperfusion injury has a great significance in improving the effect of treatment of liver transplantation. At present, the organ donation after death is the only source of organ transplantation in China. Due to organ protection is directly associated with the quality of donor organs and recipients' outcomes following transplantation, it plays a crucial role during the work of organ donation. We reviewed recent progress in mechanism of liver ischemia reperfusion injury, evaluation of donor liver, organ procurement, liver preservation and retrieval, as well as the transport of the organs.

表1 药物干预减轻供肝缺血再灌注损伤的相关研究
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