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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (02) : 148 -152. doi: 10.3877/cma.j.issn.2096-1537.2017.02.014

所属专题: 文献

综述

肝素结合蛋白与感染相关的研究进展
孙玲玲1, 蔡国龙2, 严静2,()   
  1. 1. 310053 杭州,浙江中医药大学第二临床医学院
    2. 310013 杭州,浙江医院重症医学科
  • 收稿日期:2016-11-06 出版日期:2017-05-28
  • 通信作者: 严静
  • 基金资助:
    浙江省科学技术厅(2014BAI08B00)

Progress on the study of infection and the heparin binding protein

Lingling Sun1, Guolong Cai2, Jing Yan2,()   

  1. 1. Department of Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou 310053, China
    2. Department of Intensive Care Unit, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China
  • Received:2016-11-06 Published:2017-05-28
  • Corresponding author: Jing Yan
  • About author:
    Corresponding author: Yan Jing, Email:
引用本文:

孙玲玲, 蔡国龙, 严静. 肝素结合蛋白与感染相关的研究进展[J/OL]. 中华重症医学电子杂志, 2017, 03(02): 148-152.

Lingling Sun, Guolong Cai, Jing Yan. Progress on the study of infection and the heparin binding protein[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(02): 148-152.

肝素结合蛋白(HBP)的功能多样,其可以激活单核细胞和巨噬细胞,有显著的抗菌活性、趋化特性及调节炎症反应作用;还可以修饰内皮细胞,导致血管泄漏,促进白细胞从毛细血管迁移到感染部位,并可以增加血管通透性。HBP参与疾病的病理生理过程,在血管通透性改变中发挥关键作用。HBP诊断性能作为一种生物标志物,以及潜在的使用HBP作为治疗的目标。本文综述HBP的结构和功能,辅助疾病诊断如早期呼吸循环衰竭、泌尿系统感染、细菌性皮肤感染、细菌性脑膜炎、早期脓毒症、儿童尿路感染、急性细菌性脑膜炎及作为治疗调节目标等方面的研究进展,为感染疾病的诊治提供新的手段。

Heparin binding protein (HBP) has diverse functions, It can activate monocytes and macrophages, and has significant antibacterial activity, chemotaxis and regulating inflammatory response and coagulation function. It can also modify endothelial cells, leading to vascular leakage, promoting leukocyte migration from capillaries to infected sites, and increasing vascular permeability. HBP is involved in the pathophysiological changes of the disease, and plays a key role in changing vascular permeability. Its diagnostic performance as a biomarker as well as the potential use of HBP as a therapeutic target. This paper overview the research progress on HBP in the auxiliary diagnosis of early respiratory failure, urinary tract infections, bacterial skin infections, bacterial meningitis, sepsis, early childhood urinary tract infection, acute bacterial meningitis and other inflammatory lesions, it maybe can provide a new method for the diagnosis and treatment of infectious diseases.

1
Tapper H, Karlsson A, Mörgelin M, et al. Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles[J]. Blood, 2002, 99(5): 1785-1793.
2
Gautam N, Olofsson AM, Herwald H, et al. Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability[J]. Nat Med, 2001, 7(10): 1123-1127.
3
Herwald H, Cramer H, Mörgelin M, et al. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage[J]. Cell, 2004, 116 (3): 367-379.
4
Tydén J, Herwald H, Sjöberg F, et al. Increased plasma levels of Heparin-binding protein on admission to intensive care are associsted with respiratory and circulatory failure[J]. PLoS One, 2016, 11(3): e0152035.
5
Dankiewicz J, Linder A, Annborn M, et al. Heparin-binding protein: An early indicator of critical illness and predictor of outcome in cardiac arrest[J]. Resuscitation, 2013, 84(7): 935-939.
6
Kjolvmark C, Akesson P, Linder A. Elevated urine levels of heparin-binding protein in children with urinary tract infection[J]. Pediatr Nephrol, 2012, 27(8): 1301-1308.
7
Linder A, Akesson P, Brink M, et al. Heparin-binding protein: A diagnostic marker of acute bacterial meningitis[J]. Crit Care Med, 2011, 39(4): 812-817.
8
Hans T, Anna K, Matthias M, et al. secrection of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles[J]. Blood, 2002, 99(5): 1785-1793.
9
Shafer WM, Martin LE, Spitznagel JK. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate[J]. Infect Immun, 1984, 45(1): 29-35.
10
Linder A, Soehnlein O, Akesson P. Roles of heparin-binding protein in bacterial infection[J]. J Innate Immun, 2010, 2(5): 431-438.
11
Lee TD, Gonzalez ML, Kunlar P, et al. CAP37, a neutropjil-derived inflammatory mediator, augnents leukocyte adhesion to endothelial monolayers[J]. Microvasc Res, 2003, 66(1): 38-48.
12
Bellingan GJ. The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS[J]. Thorax, 2002, 57(6): 540-546.
13
Lin Q, Shen J, Shen L, et al. Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome[J]. Crit Care, 2013, 17(4): R155.
14
Kaukonen KM, Linko R, Herwald H, et al. Heparin-binding protein (HBP) in critically ill patients with influenza A (H1N1) infection[J]. Clin Microbiol Infect, 2013, 19(12): 1122-1128.
15
Johansson J, Bratstrom O, Sjoberg E, et al. Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?[J]. Acta Anaesthesiol Scand, 2013, 57(5): 580-586.
16
Kjolvmark C, Tschernij E, Oberg J, et al. Distinguishing asymptomatic bacteriuria from urinary tract infection in the elderly-the use of urine levels of heparin-binding protein and interleukin-6[J]. Diagn Microbiol Infect Dis, 2016, 85(2): 243-248.
17
Lertdumrongluk K, Thongmee T, Kerr SJ, et al. Diagnostic accuracy of urine heparin binding protein for pediatric acute pyelonephritis[J]. Eur J Pediatr, 2015, 174(1): 43-48.
18
Pahlman LI, Morgelin M, Eckert J, et al. Streptococcal M protein : a multipotent and powerful inducer of inflammation[J], J Immunol 2006, 177(2): 1221-1228.
19
Linder A, Johansson L, Thulin P, et al. Erysipelascaused by group A streptococcua activates the contract system and induces the release of heparin-binding protein[J]. J Invest Dermatol, 2010, 130(5): 1365-1372.
20
Lundqvist K, Herwald H, Sonesson A, et al. Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of pseudomonas aeruginosa[J]. Thromb Haemost, 2004, 92(2): 281-287.
21
van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis[J]. N Engl J Med, 2004, 351(18): 1849-1859.
22
Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis inadults. Areview of 493 episodes[J]. N Engl J Med, 1993, 328(1): 21-28.
23
Linder A, Christensson B, Herwald H, et al. Heparin-binding protein: an early marker of circulatory failure in sepsis[J]. Clin Infect Dis, 2009, 49(7): 1044-1050.
24
Weber JR, Angstwurm K, Rosenkranz T, et al. Heparin inhibits leukocyte rolling in pial vessels and attenuates inflammatory changes in a rat model of experimental bacterial meningitis[J]. J Cereb Blood Flow Metab, 1997, 17(11): 1221-1229.
25
Tuomanen EI, Saukkonen K, Sande S, et al. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes[J]. J Exp Med, 1989, 170(3): 959-969.
26
Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock[J]. Crit Care Med, 2006, 34(6): 1589-1596.
27
Di Gennaro A, Kenne E, wan M, et a1. Leukotriene B4-induced changes in vascula permeability are mediated by neutrophil release of heparan_binding protein (HBP/cAP37/azurocidin)[J]. FASEB J, 2009, 23(6): 1750-1757.
28
Beran O, Herwald H, Dzupovao, et al. Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases[J]. Scand J Infect Dis, 2010, 42(8): 634-636.
29
Linder A, Arnold R, Boyd JH, et al. Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department[J]. Crit Care Med, 2015, 43(11): 2378-2386.
30
Linder A, Akesson P, Inglammar M, et al. Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock[J]. Crit Care, 2012, 16: R90.
31
Soehnlein O, Oehmcke S, Ma X, et al. Neutrophil degranulation mediates severe lung damage trigered mediates severe lung damage triggered by streptocaccal M1 protein[J]. Eur Respir J, 2008, 32(2): 405-412.
32
Johansson J, Lindbom L, Herwald H. Neutrophil-derived heparin binding protein-a mediator of increased vascular permeability after burns?[J]. Burns, 2009, 35(8): 1185-1187.
33
Medeiros RB, Oliveira FOR, Calvet CM. Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion[J]. Parasitology, 2011, 138(5): 593-601.
34
Love DC, Esko JD, Mosser DM, et al. A Heparin-binding Activity on Leishmania Amastigotes Which Mediates Adhesion to Cellular Proteoglycans[J]. J Cell Biol, 1993, 123(3): 759-766.
35
Mukhopadhyay NK, Shome K, Saha, AK, et al. Heparin binds to Leishmania donovani promastigotes and inhibits protein phosphorylation[J]. Biochem, 1989, 264(2): 517-525.
36
Snall J, Linner A, Uhlmann J, Siemens N, et al. Differential neutrophil responses to bacterial stimuli: Streptococcal strain are potent inducers of heparin-binding protein and resistin-release[J]. Sci Rep, 2016, 6: 21288.
37
Griffin MP, Gore DC, Zwischenberger JB, et al. Does heparin improve survival in experimental porcine gam-negative septic shock?[J]. Circ Shick, 1990, 31(3): 343-349.
38
Tanaka T, Tsujinaka T, Kambayashi J, et al. The effect of heparin on multiple organ failure and disseminated intravascular coagulation in a sepsis model[J]. Thromb Res, 1990, 60(4): 321-330.
39
Boldt J, Papsdorf M, Piper SN, et al. Continuous heparinization and circulating adhesion molecules in the critically ill[J]. Shock, 1999, 11(1): 13-18.
40
Meyer J, Cox CS, Herndon DN, et al. Heparin in experimental hyperdynamic sepsis[J]. Crat Care Med, 1993, 21(1): 84-89.
41
Pernerstorfer T, Hollenstein U, Hansen J, et al. Heparin blunts endotoxin-induced coagulation activation[J]. Circulation, 1999, 100(25): 2485-2490.
42
Warren BL, Eid A, Singer P, et al. Caring for the critically ill patient. Highdose antithrombin III in severe sepsis: a randomized controlled trial[J]. JAMA, 2001, 286(15): 1869-1878.
43
Abraham E, Reinhart K, Opal S, et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial[J]. JAMA, 2003, 290(2): 238-247.
44
Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis[J]. N Engl J Med, 2001, 344(10): 699-709.
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