切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (02) : 148 -152. doi: 10.3877/cma.j.issn.2096-1537.2017.02.014

所属专题: 文献

综述

肝素结合蛋白与感染相关的研究进展
孙玲玲1, 蔡国龙2, 严静2,()   
  1. 1. 310053 杭州,浙江中医药大学第二临床医学院
    2. 310013 杭州,浙江医院重症医学科
  • 收稿日期:2016-11-06 出版日期:2017-05-28
  • 通信作者: 严静
  • 基金资助:
    浙江省科学技术厅(2014BAI08B00)

Progress on the study of infection and the heparin binding protein

Lingling Sun1, Guolong Cai2, Jing Yan2,()   

  1. 1. Department of Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou 310053, China
    2. Department of Intensive Care Unit, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China
  • Received:2016-11-06 Published:2017-05-28
  • Corresponding author: Jing Yan
  • About author:
    Corresponding author: Yan Jing, Email:
引用本文:

孙玲玲, 蔡国龙, 严静. 肝素结合蛋白与感染相关的研究进展[J]. 中华重症医学电子杂志, 2017, 03(02): 148-152.

Lingling Sun, Guolong Cai, Jing Yan. Progress on the study of infection and the heparin binding protein[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(02): 148-152.

肝素结合蛋白(HBP)的功能多样,其可以激活单核细胞和巨噬细胞,有显著的抗菌活性、趋化特性及调节炎症反应作用;还可以修饰内皮细胞,导致血管泄漏,促进白细胞从毛细血管迁移到感染部位,并可以增加血管通透性。HBP参与疾病的病理生理过程,在血管通透性改变中发挥关键作用。HBP诊断性能作为一种生物标志物,以及潜在的使用HBP作为治疗的目标。本文综述HBP的结构和功能,辅助疾病诊断如早期呼吸循环衰竭、泌尿系统感染、细菌性皮肤感染、细菌性脑膜炎、早期脓毒症、儿童尿路感染、急性细菌性脑膜炎及作为治疗调节目标等方面的研究进展,为感染疾病的诊治提供新的手段。

Heparin binding protein (HBP) has diverse functions, It can activate monocytes and macrophages, and has significant antibacterial activity, chemotaxis and regulating inflammatory response and coagulation function. It can also modify endothelial cells, leading to vascular leakage, promoting leukocyte migration from capillaries to infected sites, and increasing vascular permeability. HBP is involved in the pathophysiological changes of the disease, and plays a key role in changing vascular permeability. Its diagnostic performance as a biomarker as well as the potential use of HBP as a therapeutic target. This paper overview the research progress on HBP in the auxiliary diagnosis of early respiratory failure, urinary tract infections, bacterial skin infections, bacterial meningitis, sepsis, early childhood urinary tract infection, acute bacterial meningitis and other inflammatory lesions, it maybe can provide a new method for the diagnosis and treatment of infectious diseases.

1
Tapper H, Karlsson A, Mörgelin M, et al. Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles[J]. Blood, 2002, 99(5): 1785-1793.
2
Gautam N, Olofsson AM, Herwald H, et al. Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability[J]. Nat Med, 2001, 7(10): 1123-1127.
3
Herwald H, Cramer H, Mörgelin M, et al. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage[J]. Cell, 2004, 116 (3): 367-379.
4
Tydén J, Herwald H, Sjöberg F, et al. Increased plasma levels of Heparin-binding protein on admission to intensive care are associsted with respiratory and circulatory failure[J]. PLoS One, 2016, 11(3): e0152035.
5
Dankiewicz J, Linder A, Annborn M, et al. Heparin-binding protein: An early indicator of critical illness and predictor of outcome in cardiac arrest[J]. Resuscitation, 2013, 84(7): 935-939.
6
Kjolvmark C, Akesson P, Linder A. Elevated urine levels of heparin-binding protein in children with urinary tract infection[J]. Pediatr Nephrol, 2012, 27(8): 1301-1308.
7
Linder A, Akesson P, Brink M, et al. Heparin-binding protein: A diagnostic marker of acute bacterial meningitis[J]. Crit Care Med, 2011, 39(4): 812-817.
8
Hans T, Anna K, Matthias M, et al. secrection of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles[J]. Blood, 2002, 99(5): 1785-1793.
9
Shafer WM, Martin LE, Spitznagel JK. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate[J]. Infect Immun, 1984, 45(1): 29-35.
10
Linder A, Soehnlein O, Akesson P. Roles of heparin-binding protein in bacterial infection[J]. J Innate Immun, 2010, 2(5): 431-438.
11
Lee TD, Gonzalez ML, Kunlar P, et al. CAP37, a neutropjil-derived inflammatory mediator, augnents leukocyte adhesion to endothelial monolayers[J]. Microvasc Res, 2003, 66(1): 38-48.
12
Bellingan GJ. The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS[J]. Thorax, 2002, 57(6): 540-546.
13
Lin Q, Shen J, Shen L, et al. Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome[J]. Crit Care, 2013, 17(4): R155.
14
Kaukonen KM, Linko R, Herwald H, et al. Heparin-binding protein (HBP) in critically ill patients with influenza A (H1N1) infection[J]. Clin Microbiol Infect, 2013, 19(12): 1122-1128.
15
Johansson J, Bratstrom O, Sjoberg E, et al. Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?[J]. Acta Anaesthesiol Scand, 2013, 57(5): 580-586.
16
Kjolvmark C, Tschernij E, Oberg J, et al. Distinguishing asymptomatic bacteriuria from urinary tract infection in the elderly-the use of urine levels of heparin-binding protein and interleukin-6[J]. Diagn Microbiol Infect Dis, 2016, 85(2): 243-248.
17
Lertdumrongluk K, Thongmee T, Kerr SJ, et al. Diagnostic accuracy of urine heparin binding protein for pediatric acute pyelonephritis[J]. Eur J Pediatr, 2015, 174(1): 43-48.
18
Pahlman LI, Morgelin M, Eckert J, et al. Streptococcal M protein : a multipotent and powerful inducer of inflammation[J], J Immunol 2006, 177(2): 1221-1228.
19
Linder A, Johansson L, Thulin P, et al. Erysipelascaused by group A streptococcua activates the contract system and induces the release of heparin-binding protein[J]. J Invest Dermatol, 2010, 130(5): 1365-1372.
20
Lundqvist K, Herwald H, Sonesson A, et al. Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of pseudomonas aeruginosa[J]. Thromb Haemost, 2004, 92(2): 281-287.
21
van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis[J]. N Engl J Med, 2004, 351(18): 1849-1859.
22
Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis inadults. Areview of 493 episodes[J]. N Engl J Med, 1993, 328(1): 21-28.
23
Linder A, Christensson B, Herwald H, et al. Heparin-binding protein: an early marker of circulatory failure in sepsis[J]. Clin Infect Dis, 2009, 49(7): 1044-1050.
24
Weber JR, Angstwurm K, Rosenkranz T, et al. Heparin inhibits leukocyte rolling in pial vessels and attenuates inflammatory changes in a rat model of experimental bacterial meningitis[J]. J Cereb Blood Flow Metab, 1997, 17(11): 1221-1229.
25
Tuomanen EI, Saukkonen K, Sande S, et al. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes[J]. J Exp Med, 1989, 170(3): 959-969.
26
Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock[J]. Crit Care Med, 2006, 34(6): 1589-1596.
27
Di Gennaro A, Kenne E, wan M, et a1. Leukotriene B4-induced changes in vascula permeability are mediated by neutrophil release of heparan_binding protein (HBP/cAP37/azurocidin)[J]. FASEB J, 2009, 23(6): 1750-1757.
28
Beran O, Herwald H, Dzupovao, et al. Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases[J]. Scand J Infect Dis, 2010, 42(8): 634-636.
29
Linder A, Arnold R, Boyd JH, et al. Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department[J]. Crit Care Med, 2015, 43(11): 2378-2386.
30
Linder A, Akesson P, Inglammar M, et al. Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock[J]. Crit Care, 2012, 16: R90.
31
Soehnlein O, Oehmcke S, Ma X, et al. Neutrophil degranulation mediates severe lung damage trigered mediates severe lung damage triggered by streptocaccal M1 protein[J]. Eur Respir J, 2008, 32(2): 405-412.
32
Johansson J, Lindbom L, Herwald H. Neutrophil-derived heparin binding protein-a mediator of increased vascular permeability after burns?[J]. Burns, 2009, 35(8): 1185-1187.
33
Medeiros RB, Oliveira FOR, Calvet CM. Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion[J]. Parasitology, 2011, 138(5): 593-601.
34
Love DC, Esko JD, Mosser DM, et al. A Heparin-binding Activity on Leishmania Amastigotes Which Mediates Adhesion to Cellular Proteoglycans[J]. J Cell Biol, 1993, 123(3): 759-766.
35
Mukhopadhyay NK, Shome K, Saha, AK, et al. Heparin binds to Leishmania donovani promastigotes and inhibits protein phosphorylation[J]. Biochem, 1989, 264(2): 517-525.
36
Snall J, Linner A, Uhlmann J, Siemens N, et al. Differential neutrophil responses to bacterial stimuli: Streptococcal strain are potent inducers of heparin-binding protein and resistin-release[J]. Sci Rep, 2016, 6: 21288.
37
Griffin MP, Gore DC, Zwischenberger JB, et al. Does heparin improve survival in experimental porcine gam-negative septic shock?[J]. Circ Shick, 1990, 31(3): 343-349.
38
Tanaka T, Tsujinaka T, Kambayashi J, et al. The effect of heparin on multiple organ failure and disseminated intravascular coagulation in a sepsis model[J]. Thromb Res, 1990, 60(4): 321-330.
39
Boldt J, Papsdorf M, Piper SN, et al. Continuous heparinization and circulating adhesion molecules in the critically ill[J]. Shock, 1999, 11(1): 13-18.
40
Meyer J, Cox CS, Herndon DN, et al. Heparin in experimental hyperdynamic sepsis[J]. Crat Care Med, 1993, 21(1): 84-89.
41
Pernerstorfer T, Hollenstein U, Hansen J, et al. Heparin blunts endotoxin-induced coagulation activation[J]. Circulation, 1999, 100(25): 2485-2490.
42
Warren BL, Eid A, Singer P, et al. Caring for the critically ill patient. Highdose antithrombin III in severe sepsis: a randomized controlled trial[J]. JAMA, 2001, 286(15): 1869-1878.
43
Abraham E, Reinhart K, Opal S, et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial[J]. JAMA, 2003, 290(2): 238-247.
44
Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis[J]. N Engl J Med, 2001, 344(10): 699-709.
[1] 杨水华, 何桂丹, 覃桂灿, 梁蒙凤, 罗艳合, 李雪芹, 唐娟松. 胎儿孤立性完全型肺静脉异位引流的超声心动图特征及高分辨率血流联合时间-空间相关成像的应用[J]. 中华医学超声杂志(电子版), 2023, 20(10): 1061-1067.
[2] 李培杰, 乔永杰, 张浩强, 曾健康, 谭飞, 李嘉欢, 王静, 周胜虎. 细菌培养阴性的假体周围感染诊治的最新进展[J]. 中华关节外科杂志(电子版), 2023, 17(06): 827-833.
[3] 彭旭, 邵永孚, 李铎, 邹瑞, 邢贞明. 结肠肝曲癌的诊断和外科治疗[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 108-110.
[4] 李晓阳, 刘柏隆, 周祥福. 大数据及人工智能对女性盆底功能障碍性疾病的诊断及风险预测[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 549-552.
[5] 李秉林, 吕少诚, 潘飞, 姜涛, 樊华, 寇建涛, 贺强, 郎韧. 供肝灌注液病原菌与肝移植术后早期感染的相关性分析[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 656-660.
[6] 许丁伟, 马江云, 李新成, 黄洁. Alagille综合征疑诊为先天性胆道闭锁一例并文献复习[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 681-687.
[7] 吴凤芸, 滕鑫, 刘连娟. 高帧频超声造影与增强磁共振对不同直径原发性高分化肝细胞癌的诊断价值[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 404-408.
[8] 袁媛, 赵良平, 刘智慧, 张丽萍, 谭丽梅, 閤梦琴. 子宫内膜癌组织中miR-25-3p、PTEN的表达及与病理参数的关系[J]. 中华临床医师杂志(电子版), 2023, 17(9): 1016-1020.
[9] 李达, 张大涯, 陈润祥, 张晓冬, 黄士美, 陈晨, 曾凡, 陈世锔, 白飞虎. 海南省东方市幽门螺杆菌感染现状的调查与相关危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 858-864.
[10] 卓徐鹏, 刘颖, 任菁菁. 感染性疾病与老年人低蛋白血症的相关性研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 896-899.
[11] 李田, 徐洪, 刘和亮. 尘肺病的相关研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 900-905.
[12] 李静静, 翟蕾, 赵海平, 郑波. 多囊肾合并囊肿的多重耐药菌感染一例并文献复习[J]. 中华临床医师杂志(电子版), 2023, 17(08): 920-923.
[13] 李琪, 黄钟莹, 袁平, 关振鹏. 基于某三级医院的ICU多重耐药菌医院感染影响因素的分析[J]. 中华临床医师杂志(电子版), 2023, 17(07): 777-782.
[14] 周婷, 孙培培, 张二明, 安欣华, 向平超. 北京市石景山区40岁及以上居民慢性阻塞性肺疾病诊断现状调查[J]. 中华临床医师杂志(电子版), 2023, 17(07): 790-797.
[15] 谭睿, 王晶, 於江泉, 郑瑞强. 脓毒症中高密度脂蛋白、载脂蛋白A-I和血清淀粉样蛋白A的作用研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(06): 749-753.
阅读次数
全文


摘要