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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (03) : 178 -181. doi: 10.3877/cma.j.issn.2096-1537.2017.03.005

所属专题: 重症医学 文献

专题笔谈

新型脓毒症生物标志物Presepsin(sCD14-亚型)的研究进展
赖丽仁1,()   
  1. 1. 361000 厦门大学附属第一医院急诊科
  • 收稿日期:2016-09-23 出版日期:2017-08-28
  • 通信作者: 赖丽仁

Research progress of presepsin: a newly identified soluble CD14 subtype as a marker for sepsis

Liren Lai1,()   

  1. 1. Department of Emergency and Critical Care Medicine, the First Affiliated Hospital of Xiamen University, Xiamen 361000, China
  • Received:2016-09-23 Published:2017-08-28
  • Corresponding author: Liren Lai
  • About author:
    Corresponding author: Lai Liren, Email:
引用本文:

赖丽仁. 新型脓毒症生物标志物Presepsin(sCD14-亚型)的研究进展[J]. 中华重症医学电子杂志, 2017, 03(03): 178-181.

Liren Lai. Research progress of presepsin: a newly identified soluble CD14 subtype as a marker for sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(03): 178-181.

脓毒症(sepsis)是宿主对感染的特异性反应失调导致的危及生命的器官功能损害,是重症监护病房(ICU)患者的主要死亡原因。生物标志物在早期识别诊断脓毒症、病情评价、指导抗生素应用及预后评估方面具有重要意义。不同于降钙素原(PCT)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)等炎症标志物,近来发现的一种新型生物标志物可溶性CD14亚型(Presepsin)在脓毒症的诊断及评价中显示了良好的临床意义,具有良好的临床应用前景。

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, which is the leading cause of death in critically ill patients in intensive care unit (ICU). Circulating bio-markers are helpful in early diagnosis of sepsis, evaluating the severity, guiding antimicrobials management and predicting outcomes. Unlike procalcitonin, interleukin-6 or C-reactive protein, an newly discovered bio-marker ″Presepsin″ has been shown as a useful effect on early diagnosis and accessment of sepsis, which will become to be a prospective clinical application.

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