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中华重症医学电子杂志 ›› 2018, Vol. 04 ›› Issue (04) : 314 -319. doi: 10.3877/cma.j.issn.2096-1537.2018.04.004

所属专题: 重症医学 文献

专题笔谈

白介素-35在炎症及自身免疫性疾病中的免疫学效应及临床意义
吴田田1, 童亚林2, 姚咏明3,()   
  1. 1. 100048 北京,解放军总医院第一附属医院创伤研究中心;102206 北京,北京大学国际医院肝胆外科
    2. 541002 桂林,解放军第一八一医院烧伤整形中心
    3. 100048 北京,解放军总医院第一附属医院创伤研究中心
  • 收稿日期:2017-10-08 出版日期:2018-11-28
  • 通信作者: 姚咏明
  • 基金资助:
    国家自然科学基金重点项目(81730057,81372054,81772120); 国家重点研发计划项目(2017YFC1103302)

Immunological effects and clinical significance of interleukin-35 in inflammatory and autoimmune diseases

Tiantian Wu1, Yalin Tong2, Yongming Yao3,()   

  1. 1. Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China; Hepatobiliary Surgery Department of Peking University International Hospital, Beijing 102206, China
    2. Department of Burn and Plastic Surgery, 181st Hospital of Chinese PLA, Guilin 541002, China
    3. Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China
  • Received:2017-10-08 Published:2018-11-28
  • Corresponding author: Yongming Yao
  • About author:
    Corresponding author: Yao Yongming, Email:
引用本文:

吴田田, 童亚林, 姚咏明. 白介素-35在炎症及自身免疫性疾病中的免疫学效应及临床意义[J/OL]. 中华重症医学电子杂志, 2018, 04(04): 314-319.

Tiantian Wu, Yalin Tong, Yongming Yao. Immunological effects and clinical significance of interleukin-35 in inflammatory and autoimmune diseases[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2018, 04(04): 314-319.

白介素(IL)-35是新近发现的IL-12家族抑制性细胞因子,在T细胞、B细胞免疫应答及传播性免疫耐受过程中发挥重要调控作用。目前尚未发现IL-35具备促炎效应。新近,炎症及自身免疫性疾病的相关基础及临床研究揭示了IL-35的病理生理学意义及其对疾病发生、发展及转归的重大影响。IL-35有望成为炎症及自身免疫性疾病诊断、监测及判断预后的重要免疫学指标,也是潜在的调控、治疗靶点。对IL-35表达及调控的深入研究,将为临床诊治炎症及自身免疫性疾病提供崭新的思路及方向。

Interleukin-35 (IL-35) is a newly identified inhibitory cytokine of IL-12 family. In a variety of immune responses mediated by T and B cells, IL-35 has been proved to play a vital role of immunological regulation. IL-35 further contributes to the propagation of immune tolerance, which is crucial for maintenance of immune balance and restriction of inflammatory injuries. Heretofore, no pro-inflammatory effects of IL-35 have been discovered. Recent basic and clinical studies on inflammatory and autoimmune diseases have revealed the pathophysiological significance of IL-35 and its significant impact on the occurrence, development and prognosis of diseases. IL-35 is expected to become an important immunological marker for the diagnosis, monitoring and prognosis of inflammatory and autoimmune diseases, as well as a potential target for regulation and treatment. The in-depth study of IL-35 expression and regulation will provide new ideas and directions for clinical diagnosis and treatment of inflammatory and autoimmune diseases.

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