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中华重症医学电子杂志 ›› 2019, Vol. 05 ›› Issue (03) : 258 -263. doi: 10.3877/cma.j.issn.2096-1537.2019.03.010

所属专题: 重症医学 文献

综述

间充质干细胞定向分化的调控机制在急性呼吸窘迫综合征治疗中的研究进展
张曦文1, 郭凤梅1, 邱海波1,()   
  1. 1. 210009 南京,东南大学附属中大医院重症医学科
  • 收稿日期:2018-03-13 出版日期:2019-08-28
  • 通信作者: 邱海波
  • 基金资助:
    国家自然科学基金面上项目(81471843、81571874、81671892、81670074); 江苏省医学重点学科项目(ZDXKA2016025); 中央高校基本科研业务费专项资金、江苏省普通高校研究生科研创新计划资助项目(KYZZ16_0129)

Mechanisms of directional differentiation of mesenchymal stem cells in ARDS

Xiwen Zhang1, Fengmei Guo1, Haibo Qiu1,()   

  1. 1. Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2018-03-13 Published:2019-08-28
  • Corresponding author: Haibo Qiu
  • About author:
    Corresponding author: Qiu Haibo, Email:
引用本文:

张曦文, 郭凤梅, 邱海波. 间充质干细胞定向分化的调控机制在急性呼吸窘迫综合征治疗中的研究进展[J/OL]. 中华重症医学电子杂志, 2019, 05(03): 258-263.

Xiwen Zhang, Fengmei Guo, Haibo Qiu. Mechanisms of directional differentiation of mesenchymal stem cells in ARDS[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(03): 258-263.

急性呼吸窘迫综合征(ARDS)是临床常见危重症。其主要病理特点为弥漫性肺泡上皮细胞和毛细血管内皮细胞受损、通透性增加所导致的肺间质水肿。促进肺泡上皮细胞的有效修复是ARDS治疗的关键靶点之一。间充质干细胞(MSC)具有多向分化潜能,能修复损伤肺组织结构,保护肺功能。本文对相关文章进行回顾,以深入了解MSC定向分化的调控机制及影响因素,为ARDS的治疗提供进一步的研究方向。

Acute respiratory distress syndrome (ARDS) is a syndrome of acute hypoxemic respiratory failure. The pathologic hallmark of ARDS is diffuse alveolar damage, with an injury to both capillary endothelial and alveolar epithelial. Effective repair of alveolar epithelial cells is one of the key therapeutic targets of the treatment for ARDS. With the potential of multi-directional differentiation into endothelial and epithelial cells, mesenchymal stem cells (MSCs) can restore lung structure and protect pulmonary function. The current review focuses on the mechanisms and regulatory factors that influent MSC-directed differentiation and provides further research directions in the treatment of ARDS.

图1 MSC定向分化的调控机制示意图
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