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中华重症医学电子杂志 ›› 2019, Vol. 05 ›› Issue (03) : 268 -273. doi: 10.3877/cma.j.issn.2096-1537.2019.03.012

所属专题: 文献

综述

新生儿持续性肺动脉高压的治疗进展
方赛1, 杜立中,1   
  1. 1. 310052 杭州,浙江大学医学院附属儿童医院新生儿科
  • 收稿日期:2018-10-02 出版日期:2019-08-28
  • 通信作者: 杜立中
  • 基金资助:
    国家自然科学基金(81471480,81630037)

The progress in the treatment of persistent pulmonary hypertension in neonatal

Sai Fang1, Lizhong Du,1   

  1. 1. Department of Neonatology, Children′s Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China
  • Received:2018-10-02 Published:2019-08-28
  • Corresponding author: Lizhong Du
  • About author:
    Corresponding author: Du Lizhong, Email:
引用本文:

方赛, 杜立中. 新生儿持续性肺动脉高压的治疗进展[J/OL]. 中华重症医学电子杂志, 2019, 05(03): 268-273.

Sai Fang, Lizhong Du. The progress in the treatment of persistent pulmonary hypertension in neonatal[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2019, 05(03): 268-273.

新生儿持续性肺动脉高压(PPHN)是指在新生儿出生后由于各种原因导致的肺血管阻力持续性增高,使由胎儿型循环过渡至正常"成人"型循环发生障碍,从而引起的心房和(或)动脉导管水平由右向左血液分流,临床常出现严重低氧血症甚至呼吸衰竭等症状。其病因可见于肺先天性发育不良,也可见于肺实质性病变等。该病发病率在0.2%左右,病死率可高达10%,因此对于该疾病及时有效的治疗尤为重要。目前对于该疾病的治疗除了基础治疗外,其他治疗主要包括呼吸支持及血管活性药物两方面。本文总结了目前PPHN的治疗进展,为临床医师提供参考依据。

Persistent pulmonary hypertension of neonatal (PPHN) refers to the continuous increase of pulmonary vascular resistance after birth, which causes the abnormal development from fetal circulation to ″adult″ type circulatory and the subsequent right to left shunt through atrial septum or arterial duct. Clinical symptoms include severe hypoxemia and even respiratory failure. PPHN can be seen in the congenital dysplasia of the lung, as well as in the substantial lung diseases. The incidence of the disease is around 0.2%, and mortality about 10%. In addition to the basic treatment of the disease, timely and effective treatments like respiratory support and vasoactive drugs can significantly reduce the incidence and mortality of the disease. This article summarizes the current treatment progress in persistent pulmonary hypertension of neonatal, and provides useful information for clinicians.

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