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中华重症医学电子杂志 ›› 2020, Vol. 06 ›› Issue (02) : 215 -222. doi: 10.3877/cma.j.issn.2096-1537.2020.02.022

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综述

急性呼吸窘迫综合征的表型及内型研究进展
石颖1, 左祥荣1, 曹权1,()   
  1. 1. 210029 南京医科大学第一附属医院重症医学科
  • 收稿日期:2020-02-26 出版日期:2020-05-28
  • 通信作者: 曹权
  • 基金资助:
    国家自然科学基金(81200159); 江苏省"六大人才高峰"项目(2012-WS-028); 江苏省"青年医学人才"项目(QNRC2016557); 江苏省高层次卫生人才"六个一工程"拔尖人才科研项目(LGY2019067)

Progress in research of phenotypes and endotypes in acute respiratory distress syndrome

Ying Shi1, Xiangrong Zuo1, Quan Cao1,()   

  1. 1. Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2020-02-26 Published:2020-05-28
  • Corresponding author: Quan Cao
  • About author:
    Corresponding author: Cao Quan, Email:
引用本文:

石颖, 左祥荣, 曹权. 急性呼吸窘迫综合征的表型及内型研究进展[J]. 中华重症医学电子杂志, 2020, 06(02): 215-222.

Ying Shi, Xiangrong Zuo, Quan Cao. Progress in research of phenotypes and endotypes in acute respiratory distress syndrome[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(02): 215-222.

急性呼吸窘迫综合征(ARDS)是一种由多种病因引起的危及生命的呼吸衰竭。由于ARDS在病因、病理、发病机制、临床表现、影像学表现及基因特性等多方面存在异质性,故ARDS存在不同的表型及内型,目前仍缺乏特异性治疗药物,且病死率仍居高不下。本文通过回顾近年来的相关研究,介绍ARDS不同表型及内型的研究进展,以期帮助重症监护病房医师更好地认识ARDS表型及内型,并为未来ARDS的精准治疗提供一定参考。

Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory failure that can result from a variety of causes. Because of the heterogeneity in etiology, pathology, pathogenesis, clinical manifestations, imaging manifestations, and gene characteristics of ARDS, there are different phenotypes or endotypes of ARDS. This paper reviews the relevant research results in recent years, and the progress in research of different phenotypes and endotypes in ARDS, with an aim to help intensive care unit (ICU) doctors to better understand the phenotypes and endotypes of ARDS and provide some reference for ARDS precision medicine in future.

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