切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2023, Vol. 09 ›› Issue (01) : 89 -94. doi: 10.3877/cma.j.issn.2096-1537.2023.01.015

综述

中国脓毒症流行病学的研究进展
王伊帆1, 陈燕1, 彭劲民1, 杜斌1, 翁利1,()   
  1. 1. 100730 北京,中国医学科学院 北京协和医学院 北京协和医院内科ICU 协和转化医学中心
  • 收稿日期:2022-06-06 出版日期:2023-02-28
  • 通信作者: 翁利
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-062)

Epidemiology of sepsis in China

Yifan Wang1, Yan Chen1, Jinmin Peng1, Bin Du1, Li Weng1,()   

  1. 1. Department of Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Translational Medical Center, Beijing 100730, China
  • Received:2022-06-06 Published:2023-02-28
  • Corresponding author: Li Weng
引用本文:

王伊帆, 陈燕, 彭劲民, 杜斌, 翁利. 中国脓毒症流行病学的研究进展[J]. 中华重症医学电子杂志, 2023, 09(01): 89-94.

Yifan Wang, Yan Chen, Jinmin Peng, Bin Du, Li Weng. Epidemiology of sepsis in China[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 89-94.

脓毒症是机体因急性感染引起的宿主反应失调所致的危及生命的器官功能障碍,已成为严重威胁人类健康的公共卫生问题。我国脓毒症的流行病学研究欠全面,但均表明脓毒症发病率与病死率高,远期预后差,疾病负担重,与高收入国家存在差距。本文就目前国内脓毒症流行病学相关研究进行综述,为医疗卫生资源的调整和未来的研究提供方向。

Sepsis is defined as life-threatening organ dysfunction caused by adysregulated host response to infection, considered as a major global public health problem. Though relevant studies focused on Chinese sepsis epidemiology were not comprehensive, those studies still suggested that compared with high-income countries (HICs), the incidence and mortality of sepsis in China were relatively high, the long-term outcomes were poor and the burden of sepsis was heavy. This review of the current domestic sepsis epidemiology-related studies provides research directions for the adjustment of medical and health resources and future research.

1
Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study [J]. Lancet, 2020, 395(10219): 200-211.
2
Fleischmann-Struzek C, Mellhammar L, Rose N, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis [J]. Intensive Care Med, 2020, 46(8): 1552-1562.
3
Reinhart K, Daniels R, Kissoon N, et al. Recognizing Sepsis as a Global Health Priority-a WHO Resolution [J]. N Engl J Med, 2017, 377(5): 414-417.
4
邹燕群, 廖兰凯, 魏宗海, 等. "拯救脓毒症运动"1 h Bundle依从性调查及对患者预后的影响 [J]. 中华危重病急救医学, 2021, 33(6): 671-675.
5
Kahn JM, Davis BS, Yabes JG, et al. Association between state-mandated protocolized sepsis care and in-hospital mortality among adults with sepsis [J]. JAMA, 2019, 322(3): 240-250.
6
Levy MM, Gesten FC, Phillips GS, et al. Mortality changes associated with mandated public reporting for sepsis. The results of the New York State Initiative [J]. Am J Respir Crit Care Med, 2018, 198(11): 1406-1412.
7
Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [J]. Chest, 1992, 101(6): 1644-1655.
8
Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference [J]. Intensive Care Med, 2003, 29(4): 530-538.
9
Cassini A, Fleischmann-Struzek C, Naghavi M, et al. Future directions and priorities in sepsis epidemiology research: a call for action [J]. Bull World Health Organ, 2021, 99(5): 398-401.
10
World Health Organization. Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions [EB/OL]. (2020-09-09) [2020-06-06].

URL    
11
江伟, 杜斌. 中国脓毒症流行病学现状 [J]. 医学研究生学报, 2019, 32(1): 5-8.
12
Xie J, Wang H, Kang Y, et al. The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey [J]. Crit Care Med, 2020, 48(3): e209-e218.
13
Zhou J, Tian H, Du X, et al. Population-based epidemiology of sepsis in a subdistrict of Beijing [J]. Crit Care Med, 2017, 45(7): 1168-1176.
14
Tian HC, Zhou JF, Weng L, et al. Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database [J]. Chin Med J (Engl), 2019, 132(17): 2039-2045.
15
Wang Y, Sun B, Yue H, et al. An epidemiologic survey of pediatric sepsis in regional hospitals in China [J]. Pediatr Crit Care Med, 2014, 15(9): 814-820.
16
Xiao C, Wang S, Fang F, et al. Epidemiology of pediatric severe sepsis in main PICU centers in Southwest China [J]. Pediatr Crit Care Med, 2019, 20(12): 1118-1125.
17
Brilli RJ, Goldstein B. Pediatric sepsis definitions: past, present, and future [J]. Pediatr Crit Care Med, 2005, 6(3 Suppl): S6-8.
18
Goldstein B, Giroir B, Randolph A, et al. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics [J]. Pediatr Crit Care Med, 2005, 6(1): 2-8.
19
Fleischmann-Struzek C, Rose N, Freytag A, et al. Epidemiology and costs of postsepsis morbidity, nursing care dependency, and mortality in Germany, 2013 to 2017 [J]. JAMA Netw Open, 2021, 4(11): e2134290.
20
Yende S, Austin S, Rhodes A, et al. Long-term quality of life among survivors of severe sepsis: analyses of two international trials [J]. Crit Care Med, 2016, 44(8): 1461-1467.
21
Zhang K, Mao X, Fang Q, et al. Impaired long-term quality of life in survivors of severe sepsis : Chinese multicenter study over 6 years [J]. Anaesthesist, 2013, 62(12): 995-1002.
22
谢蓉蓉. 中国ICU脓毒症患者的远期预后调查 [D]. 南京: 东南大学, 2020.
23
Cdc Weekly C. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)—China, 2020 [J]. China CDC Weekly, 2020, 2(8): 113-122.
24
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J]. Lancet, 2020, 395(10229): 1054-1062.
25
Zhang X, Zhang W, Chen S. Shanghai's life-saving efforts against the current omicron wave of the COVID-19 pandemic [J]. Lancet, 2022, 399(10340): 2011-2012.
26
Cheung PH, Chan CP, Jin DY. Lessons learned from the fifth wave of COVID-19 in Hong Kong in early 2022 [J]. Emerg Microbes Infect, 2022, 11(1): 1072-1078.
27
Say L, Chou D, Gemmill A, et al. Global causes of maternal death: a WHO systematic analysis [J]. Lancet Glob Health, 2014, 2(6): e323-333.
28
Zhao Z, Han S, Yao G, et al. Pregnancy-related ICU admissions from 2008 to 2016 in China: a first multicenter report [J]. Crit Care Med, 2018, 46(10): e1002-e1009.
29
World Health Organization. Statement on maternal sepsis [EB/OL]. 2017.

URL    
30
Bowyer L, Robinson HL, Barrett H, et al. SOMANZ guidelines for the investigation and management sepsis in pregnancy [J]. Aust N Z J Obstet Gynaecol, 2017, 57(5): 540-551.
31
Weng L, Hu Y, Sun Z, et al. Place of death and phenomenon of going home to die in Chinese adults: A prospective cohort study [J]. Lancet Reg Health West Pac, 2022, 18: 100301.
32
农工党中央. 加强新冠肺炎出院患者健康管理 [J]. 前进论坛, 2021, (10): 24.
33
杜欣欣, 古丽菲热·塔依尔, 王毅, 等. 新型冠状病毒肺炎合并脓毒症的临床诊治研究 [J]. 临床内科杂志, 2020, 37(3): 206-208.
[1] 韩媛媛, 热孜亚·萨贝提, 冒智捷, 穆福娜依·艾尔肯, 陆晨, 桑晓红, 阿尔曼·木拉提, 张丽. 组合式血液净化治疗对脓毒症患者血清炎症因子水平和临床预后的影响[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 272-278.
[2] 孟建标, 张庚, 焦燕娜. 脓毒症合并心功能障碍患者早期肠道微生态改变的探讨[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 279-285.
[3] 陈宇, 冯芳, 张露, 刘健. 基于生物信息学分析筛选脓毒症心肌病关键致病基因[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 286-291.
[4] 莫小乔, 胡喆莹, 廖冬花, 谢天. 脓毒症继发急性肾损伤患者死亡风险预测模型构建及评估[J]. 中华危重症医学杂志(电子版), 2023, 16(03): 198-206.
[5] 张晓燕, 肖东琼, 高沪, 陈琳, 唐发娟, 李熙鸿. 转录因子12过表达对脓毒症相关性脑病大鼠大脑皮质的保护作用及其机制[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 540-549.
[6] 魏徐, 张鸽, 伍金林. 新生儿脓毒症相关性凝血病的监测和治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 379-386.
[7] 姚咏明. 如何精准评估烧伤脓毒症患者免疫状态[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 552-552.
[8] 窦上文, 邓欢, 刘邦锋, 岳高远志, 朱华财, 刘永达. 术前复查尿培养在预测微通道经皮肾镜取石术相关感染并发症中的作用[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(04): 361-366.
[9] 李伟, 卓剑, 黄川, 黄有攀. Lac、HO-1、sRAGE、CRP/ALB表达及脓毒症并发ARDS危险因素分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 514-516.
[10] 苗软昕, 乔晞. Toll样受体在脓毒症性急性肾损伤中的作用[J]. 中华肾病研究电子杂志, 2023, 12(04): 210-214.
[11] 李世明, 黄蔚, 刘玲. HMGB1介导脓毒症相关凝血功能障碍的作用机制及其治疗进展[J]. 中华重症医学电子杂志, 2023, 09(03): 269-273.
[12] 高超, 巢杰, 邱海波. T-bet:脓毒症免疫失衡中Th17细胞的新型调节分子[J]. 中华重症医学电子杂志, 2023, 09(03): 280-285.
[13] 李达, 张大涯, 陈润祥, 张晓冬, 黄士美, 陈晨, 曾凡, 陈世锔, 白飞虎. 海南省东方市幽门螺杆菌感染现状的调查与相关危险因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 858-864.
[14] 谭睿, 王晶, 於江泉, 郑瑞强. 脓毒症中高密度脂蛋白、载脂蛋白A-I和血清淀粉样蛋白A的作用研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(06): 749-753.
[15] 蔡荇, 郑瑞强. 肝素结合蛋白在脓毒症中的应用及研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(04): 487-490.
阅读次数
全文


摘要