2020年至2022年中国重症医学临床研究进展

doi:10.3877/cma.j.issn.2096-1537.2024.01.008

近年来中国重症医学临床研究进展不少，体现在各个不同的系统及研究领域。其中最受瞩目的新型冠状病毒肺炎研究非常多，有研究认为病毒载量和演变与病情轻重相关，发病机制与免疫失调相关，严重时甚至可能损伤心肌。目前呼吸治疗取得一定的成效，但仍需进一步的临床试验验证。此外，脓毒症仍然是造成社会疾病负担较重的疾病之一，对免疫抑制中性粒细胞的研究成果或可成为新的治疗靶点，对异质性大的患者进行分级管理有助于调整液体复苏策略。除了常规的临床研究方法，近年兴起的人工智能机器学习应用于急性呼吸窘迫综合征的表型分析具有良好的适配性。未来，精准治疗的个体化诊治原则将成为重症医学日常工作的重要指导。本文综述2020年至2022年来中国重症医学临床研究的进展，旨在为未来进一步的研究提供理论支持。

关键词: 重症医学, 新型冠状病毒肺炎, 临床研究, 治疗策略, 预后

In recent years, a variety of critical care clinical studies were developed in China, which arose in different systems or study areas. Chief among these endeavors, the investigation into corona virus disease 2019 (COVID-19) has garnered paramount attention. Some studies demonstrate that RNA capacity of COVID-19 was associated with the severity in clinical status, while others have suggested that immune system dysregulation contributes to the etiology of COVID-19, potentially leading to myocardial damage. Encouragingly, the positive therapeutic outcomes have been reported concerning respiratory strategies. Moreover, sepsis remains a societal burden, and recent research highlighting immunosuppressed neutrophils poses a promising avenue for novel therapeutic interventions. The implementation of hierarchical patient management has facilitated nuanced adjustments in fluid resuscitation strategies. Apart from the conventional research strategies, the contemporary integration of machine learning into phenotypic analysis, particularly in acute respiratory distress syndrome, exhibits promising adaptability. In the future, the individualized diagnosis and treatment principle of precision therapy will become an important guide for the daily work of critical care medicine. This paper offers a comprehensive review of clinical research conducted in China over the past three years, aiming to provide a robust theoretical foundation for future study.

Key words: Intens Care Medicine, Corona virus disease 2019, Clinical study, Therapeutic strategy, Prognosis

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Progress in critical care study of China in 2020—2022

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Progress in critical care study of China in 2020—2022