切换至 "中华医学电子期刊资源库"

第五届中国出版政府奖音像电子网络出版物奖提名奖

中国科技核心期刊

中国科学引文数据库(CSCD)来源期刊

中华重症医学电子杂志 ›› 2024, Vol. 10 ›› Issue (01) : 42 -47. doi: 10.3877/cma.j.issn.2096-1537.2024.01.007

综述

冷诱导RNA结合蛋白与炎症反应的研究进展
吴宗盛1, 谢剑锋1,(), 邱海波1,()   
  1. 1. 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
  • 收稿日期:2023-03-27 出版日期:2024-02-28
  • 通信作者: 谢剑锋, 邱海波
  • 基金资助:
    国家自然科学基金重点项目(81930058); 国家自然科学基金专项项目(82341032); 国家自然科学基金青年项目(82002091)

Cold-inducible RNA-binding protein and inflammatory response

Zongsheng Wu1, Jianfeng Xie1,(), Haibo Qiu1,()   

  1. 1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2023-03-27 Published:2024-02-28
  • Corresponding author: Jianfeng Xie, Haibo Qiu
引用本文:

吴宗盛, 谢剑锋, 邱海波. 冷诱导RNA结合蛋白与炎症反应的研究进展[J]. 中华重症医学电子杂志, 2024, 10(01): 42-47.

Zongsheng Wu, Jianfeng Xie, Haibo Qiu. Cold-inducible RNA-binding protein and inflammatory response[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2024, 10(01): 42-47.

冷诱导RNA结合蛋白在机体的主要组织器官中广泛表达,是位于细胞核内的RNA伴侣蛋白。近年来研究证实,冷诱导RNA结合蛋白(CIRP)可从损伤的组织细胞中释放至细胞外,作为损伤相关分子模式(DAMPs)与免疫细胞相互作用,参与到级联放大的炎症反应过程。它在脓毒症、急性重症胰腺炎和心肺复苏术后等重症患者外周血中的显著升高与预后不良密切相关。本文就胞外CIRP释放方式及其与靶细胞效应和作用机制作一综述,旨在为开展CIRP相关的研究提供理论依据和参考。

Cold-inducible RNA-binding protein (CIRP) is an RNA chaperone protein localized in nucleus and widely expressed in most tissue and organs. In recent years, numerous studies have confirmed that CIRP could be released from injured tissue and cells, interacting with immune cells and being involved in triggering inflammatory response as a damage-associated molecular patterns (DAMPs). In addition, elevation of extracellular CIRP have been found in peripheral blood in septic patients, severe acute pancreatitis patients and post-cardiopulmonary resuscitation patients, associated with poor prognosis. The purpose of this review is to provide a theoretical basis for conducting CIRP relevant research through summarize current knowledge on routes of extracellular CIRP being released, its effects on target cell, and underlying mechanisms.

图1 CIRP的释放与作用受体 注:CIRP为冷诱导RNA结合蛋白;GSDMD为Gasdermin D;TLR4为Toll样受体4;TREM-1为髓样细胞触发受体-1;IL-6R为白介素-6受体
表1 CIRP对免疫细胞的效应及机制
1
Zindel J, Kubes P. DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation [J]. Annu Rev Pathol, 2020, 15: 493-518.
2
Zhong P, Peng J, Yuan M, et al. Cold-inducible RNA-binding protein (CIRP) in inflammatory diseases: molecular insights of its associated signalling pathways [J]. Scand J Immunol, 2021, 93(1): e12949.
3
Nishiyama H, Itoh K, Kaneko Y, et al. A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth [J]. J Cell Biol, 1997, 137(4): 899-908.
4
Qiang X, Yang WL, Wu R, et al. Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis [J]. Nat Med, 2013, 19(11): 1489-1495.
5
Murao A, Aziz M, Wang H, et al. Release mechanisms of major DAMPs [J]. Apoptosis, 2021, 26(3-4): 152-162.
6
Mao LP, Jiao Y, Xiang JH, et al. Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanism [J]. Ann Transl Med, 2021, 9(18): 1470.
7
Murao A, Tan C, Jha A, et al. Exosome-mediated eCIRP release from macrophages to induce inflammation in sepsis [J]. Front Pharmacol, 2021, 12: 791648.
8
Tan C, Reilly B, Jha A, et al. Active release of eCIRP via Gasdermin D channels to induce inflammation in sepsis [J]. J Immunol, 2022, 208(9): 2184-2195.
9
Reilly B, Tan C, Murao A, et al. Necroptosis-mediated eCIRP release in sepsis [J]. J Inflamm Res, 2022, 15: 4047-4059.
10
Zhang F, Brenner M, Yang WL, et al. A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice [J]. Sci Rep, 2018, 8(1): 3052.
11
Lee Y, Reilly B, Tan C, et al. Extracellular CIRP induces macrophage extracellular trap formation via Gasdermin D activation [J]. Front Immunol, 2021, 12: 780210.
12
Li Z, Fan EK, Liu J, et al. Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma [J]. Cell Death Dis, 2017, 8(5): e2775.
13
Zhou M, Aziz M, Denning NL, et al. Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation [J]. JCI Insight, 2020, 5(5): e133715.
14
Khan MM, Yang WL, Brenner M, et al. Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress [J]. Sci Rep, 2017, 7: 41363.
15
Murata K, Murao A, Aziz M, et al. Extracellular CIRP induces novel nectin-2+ (CD112+) neutrophils to promote Th1 differentiation in sepsis [J]. J Immunol, 2023, 210(3): 310-321.
16
Ode Y, Aziz M, Wang P. CIRP increases ICAM-1(+) phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis [J]. J Leukocyte Biol, 2018, 103(4): 693-707.
17
Murao A, Arif A, Brenner M, et al. Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis [J]. FASEB J, 2020, 34(7): 9771-9786.
18
Chen K, Murao A, Arif A, et al. Inhibition of efferocytosis by extracellular CIRP-induced neutrophil extracellular traps [J]. J Immunol, 2021, 206(4): 797-806.
19
Royster W, Jin H, Wang P, et al. Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis [J]. Mol Med, 2021, 27(1): 55.
20
Bolognese AC, Sharma A, Yang WL, et al. Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner [J]. Cell Mol Immunol, 2018, 15(1): 38-47.
21
Chen K, Cagliani J, Aziz M, et al. Extracellular CIRP activates STING to exacerbate hemorrhagic shock [J]. JCI Insight, 2021, 6(14): e143715.
22
McGinn J, Zhang F, Aziz M, et al. The protective effect of a short peptide derived from cold-inducible RNA-binding protein in renal ischemia-reperfusion injury [J]. Shock, 2018, 49(3): 269-276.
23
Mcginn JT, Aziz M, Zhang F, et al. Cold-inducible RNA-binding protein-derived peptide C23 attenuates inflammation and tissue injury in a murine model of intestinal ischemia-reperfusion [J]. Surgery, 2018, 164(6): 1191-1197.
24
Zhang F, Yang WL, Brenner M, et al. Attenuation of hemorrhage-associated lung injury by adjuvant treatment with C23, an oligopeptide derived from cold-inducible RNA-binding protein [J]. J Trauma Acute Care Surg, 2017, 83(4): 690-697.
25
Denning NL, Aziz M, Murao A, et al. Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis [J]. JCI Insight, 2020, 5(5): e134172.
26
Denning NL, Aziz M, Diao L, et al. Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis [J]. Mol Med, 2020, 26(1): 121.
27
Sharma A, Brenner M, Jacob A, et al. Extracellular CIRP activates the IL-6Rα/STAT3/Cdk5 pathway in neurons [J]. Mol Neurobiol, 2021, 58(8): 3628-3640.
28
Zhou Y, Dong H, Zhong Y, et al. The cold-inducible RNA-binding protein (CIRP) level in peripheral blood predicts sepsis outcome [J]. PLoS one, 2015, 10(9): e0137721.
29
王明禄, 刘名胜, 邢柏, 等. 血清冷诱导RNA结合蛋白与脓毒性休克患者病情严重程度及预后的相关性 [J]. 中国急救医学, 2021, 41(2): 117-121.
30
Guo Q, Song WD, Li HY, et al. Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality [J]. Respir Res, 2020, 21(1): 192.
31
Schagatay F, Diamant K, Lidén M, et al. Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19 [J]. Front Immunol, 2022, 13: 945603.
32
Wang L, Li RF, Guan XL, et al. The value of extracellular cold-inducible RNA-binding protein (eCIRP) in predicting the severity and prognosis of patients after cardiac arrest: a preliminary observational study [J]. Shock, 2021, 56(2): 229-236.
33
Gong JD, Qi XF, Zhang Y, et al. Increased admission serum cold-inducible RNA-binding protein concentration is associated with prognosis of severe acute pancreatitis [J]. Clin Chim Acta, 2017, 471: 135-142.
34
Linders J, Madhi R, Rahman M, et al. Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis [J]. Lab Invest, 2020, 100(12): 1618-1630.
[1] 魏徐, 张鸽, 伍金林. 新生儿脓毒症相关性凝血病的监测和治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 379-386.
[2] 钱龙, 陆晓峰, 王行舟, 杜峻峰, 沈晓菲, 管文贤. 神经系统调控胃肠道肿瘤免疫应答研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 86-89.
[3] 曹飞, 庞俊. 前列腺癌免疫微环境中免疫抑制性细胞分类及其作用机制[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 121-125.
[4] 王可, 范彬, 李多富, 刘奎. 两种疝囊残端处理方法在经腹腹膜前腹股沟疝修补术中的疗效比较[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 692-696.
[5] 缪慧, 吴震. 茚达特罗格隆溴铵对COPD患者肺功能和炎症反应的影响[J]. 中华肺部疾病杂志(电子版), 2023, 16(06): 852-855.
[6] 李冠东, 梁文启, 孙兴成, 王美堂. 利奈唑胺治疗G肺炎疗效及对免疫功能和炎症反应的影响[J]. 中华肺部疾病杂志(电子版), 2023, 16(05): 700-702.
[7] 姜东, 冉龙艳, 雷传江, 徐静. 脓毒症的前世今生及序贯器官衰竭认知及理念[J]. 中华肺部疾病杂志(电子版), 2023, 16(05): 605-610.
[8] 曹守青, 来东, 焦启龙, 安哲昆, 李修彬. 免疫细胞在肾脏缺血再灌注损伤修复中的作用研究进展[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(01): 45-50.
[9] 朱兴墅, 郑师尧, 王庆惠, 陈力, 刘旺武, 纪辉涛, 王瑜, 赵虎, 方永超. 蛋白磷酸酶-1催化亚基β在结直肠癌诊断、预后及免疫浸润中的生物信息学分析[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(06): 321-330.
[10] 许磊, 孙杰, 陈先志, 张家泉, 李旺勇, 冯其柱, 王琦. 血液净化治疗在高血脂性重症胰腺炎中的应用[J]. 中华肝脏外科手术学电子杂志, 2023, 12(04): 464-468.
[11] 孙骎, 杨毅, 彭菲. Gasdermin蛋白家族在脓毒症细胞焦亡中的作用研究进展[J]. 中华重症医学电子杂志, 2023, 09(04): 379-384.
[12] 谢森, 韩轶鹏, 秦至臻, 赵卫良, 毛更生. 脑损伤后慢性炎症反应致巨大占位效应一例报道[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(06): 379-381.
[13] 邹勇, 顾应江, 丁昊, 杨呈浩, 陈岷辉, 蔡昱. 基于Nrf2/HO-1及NF-κB信号通路探讨葛根素对大鼠脑出血后早期炎症反应及氧化应激反应的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 271-277.
[14] 王丽丽, 张春霞, 申磊, 吴立娜, 潘青, 冯雪. 吗替麦考酚酯联合雷公藤多苷及糖皮质激素治疗对IgA肾病患者肾功能、炎症因子和氧化应激的影响[J]. 中华临床医师杂志(电子版), 2023, 17(12): 1285-1290.
[15] 张赟辉, 罗军, 刘栗丽, 汪宏, 耿克明. 腹膜透析与血液透析对老年终末期肾病患者营养状况及炎症反应的影响[J]. 中华临床医师杂志(电子版), 2023, 17(04): 419-423.
阅读次数
全文


摘要