基于科学知识图谱的ICU后综合征研究热点及趋势分析

doi:10.3877/cma.j.issn.2096-1537.2024.02.013

目的

探讨ICU后综合征（PICS）研究热点及研究趋势，以期为我国PICS研究的发展提供参考。

方法

以“post-intensive care syndrome”为主题词，借助CiteSpace对2000年1月1日至2022年12月31日Web of Science核心集数据库检索的相关文献进行分析，梳理国家、研究机构和文献作者的发文情况、主要研究热点及趋势。

结果

共纳入2643篇PICS相关文献，发文量前3位的国家分别为美国、英国和加拿大；发文量前3位的研究机构分别是约翰霍普金斯大学、范德比尔特大学、多伦多大学；发文量前3位的作者分别是Dale M. Needham、Ramona O. Hopkins、E. Wesley Ely。关键词突变性分析主要为生活质量、严重脓毒症、危重症患者、急性肾衰竭、机械通气延长、幸存者。文献共被引及聚类分析，共形成13个聚类，主要集中于PICS的好发人群，如急性肾损伤、急性肺损伤、多器官功能衰竭、脓毒症休克，以及其临床症状，如ICU获得性衰弱、精神病学症状、虚弱等。根据高被引文献分析，研究主要集中在急性呼吸窘迫综合征（ARDS）、休克等危重症幸存者结局及生活质量、抑郁、创伤后应激障碍等症状的流行病学特点、PICS的概念及其预防管理策略。

结论

不同危重症幸存者PICS的流行病学特征、影响因素和远期结局，不同维度症状的长期轨迹变化特征、远期生活质量的评估及调查、预防管理策略为目前国际研究热点及方向。

关键词: ICU后综合征, 文献计量学, CiteSpace, 研究热点, 聚类分析

Objective

To explore research hotspots and trends in post-ICU syndrome in the world and provide guidance and theoretical basis for the future research.

Methods

CiteSpace scientific knowledge map was used to analyze literatures retrieved from the Web of Science core collection database from 2000 to 2022 in post-ICU syndrome.

Results

A total of 2643 papers related to post-ICU syndrome were included, in terms of number of articles, the top 3 countries were USA, UK and Canada; the top 3 research institutions were Johns Hopkins University, Vanderbilt University, University of Toronto; the top 3 authors were Dale M. Needham, Ramona O. Hopkins, E. Wesley Ely. Keyword with strongest bursts including quality of life, severe sepsis, critical ill patient, acute renal failure, prolonged mechanical ventilation, survivors. Literature co-citation and cluster analysis resulted in 13 clusters that focused on the well-prevalent population of post-ICU syndrome, such as patients with acute kidney injury, acute lung injury, multi-organ failure, or septic shock, and on clinical symptom, such as ICU-acquired weakness, psychiatric symptoms, and frailty. According to analysis of top cited literature, research hotspots focused on epidemiology characteristics about outcome and quality of life in survivors of ARDS and shock patients, on depression, on post-traumatic stress disorder, and on concept of post-ICU syndrome and preventive strategies.

Conclusion

The epidemiology characteristics and long-term outcome of PICS in survivors of critical illnesses, the characteristics of long-term trajectory of PICS, assessment of long-term quality of life and preventive strategies of PICS are hotspots and future directions in international research.

Key words: Post-Intensive Care Unit Syndrome, Bibliometrics, CiteSpace, Research hotspots, Cluster analysis

图1 2000年至2022年ICU后综合征文献数量变化趋势

表1 2000年至2022年ICU后综合征发文量排名前10位的国家分布

排名	国家	发文量	中介中心性
1	美国	1124	0.25
2	英国	300	0.17
3	加拿大	256	0.10
4	澳大利亚	251	0.10
5	荷兰	177	0.07
6	德国	166	0.02
7	法国	149	0.06
8	中国	118	0.03
9	意大利	108	0.07
10	苏格兰	82	0.02

表1 2000年至2022年ICU后综合征发文量排名前10位的国家分布

排名	国家	发文量	中介中心性
1	美国	1124	0.25
2	英国	300	0.17
3	加拿大	256	0.10
4	澳大利亚	251	0.10
5	荷兰	177	0.07
6	德国	166	0.02
7	法国	149	0.06
8	中国	118	0.03
9	意大利	108	0.07
10	苏格兰	82	0.02

图2 2000年至2022年ICU后综合征文献研究机构及作者网络知识图谱。图a为研究机构，图b为文献作者

表2 2000年至2022年PICS高频关键词前20位

序号	关键词	频数	中介中心性
1	critical illness	881	0.04
2	quality of life	841	0.03
3	intensive care unit	798	0.08
4	survivors	725	0.03
5	intensive care	695	0.03
6	outcome	528	0.07
7	mortality	375	0.07
8	post-traumatic stress disorder	352	0.07
9	cognitive impairment	293	0.05
10	critically ill patient	259	0.05
11	mechanical ventilation	257	0.08
12	respiratory distress syndrome	255	0.06
13	symptoms	211	0.03
14	risk factor	203	0.07
15	depression	202	0.03
16	acute lung injury	181	0.04
17	impact	179	0.05
18	care	173	0.04
19	follow-up	147	0.03
20	health	143	0.04

表2 2000年至2022年PICS高频关键词前20位

序号	关键词	频数	中介中心性
1	critical illness	881	0.04
2	quality of life	841	0.03
3	intensive care unit	798	0.08
4	survivors	725	0.03
5	intensive care	695	0.03
6	outcome	528	0.07
7	mortality	375	0.07
8	post-traumatic stress disorder	352	0.07
9	cognitive impairment	293	0.05
10	critically ill patient	259	0.05
11	mechanical ventilation	257	0.08
12	respiratory distress syndrome	255	0.06
13	symptoms	211	0.03
14	risk factor	203	0.07
15	depression	202	0.03
16	acute lung injury	181	0.04
17	impact	179	0.05
18	care	173	0.04
19	follow-up	147	0.03
20	health	143	0.04

图3 2000年至2022年ICU后综合征研究领域关键词突现性分析25位时间序列图

图4 2000年至2022年ICU后综合征相关研究文献共被引分析聚类知识图谱

表3 2000至2022年ICU后综合征文献被引次数排名前10位的文献列表

排名	被引次数（次）	中介中心性	作者	发表年份（年）	发表期刊
1	148	0.03	Pandharipande PP等	2013	New Engl J Med
2	120	0.13	Needham DM等	2012	Crit Care Med
3	106	0.05	Parker AM等	2015	Crit Care Med
4	100	0.04	Herridge MS等	2011	New Engl J Med
5	92	0.05	Rabiee A等	2016	Crit Care Med
6	90	0.05	Jackson JC等	2014	Lanct Resp Med
7	83	0.08	Needham DM等	2017	Am J Resp Crit Care
8	82	0.03	Iwashyna TJ等	2010	JAMA
9	80	0.02	Nikayin S等	2016	Gen Hosp Psychiat
10	75	0.02	Marra A等	2018	Crit Care Med

表3 2000至2022年ICU后综合征文献被引次数排名前10位的文献列表

排名	被引次数（次）	中介中心性	作者	发表年份（年）	发表期刊
1	148	0.03	Pandharipande PP等	2013	New Engl J Med
2	120	0.13	Needham DM等	2012	Crit Care Med
3	106	0.05	Parker AM等	2015	Crit Care Med
4	100	0.04	Herridge MS等	2011	New Engl J Med
5	92	0.05	Rabiee A等	2016	Crit Care Med
6	90	0.05	Jackson JC等	2014	Lanct Resp Med
7	83	0.08	Needham DM等	2017	Am J Resp Crit Care
8	82	0.03	Iwashyna TJ等	2010	JAMA
9	80	0.02	Nikayin S等	2016	Gen Hosp Psychiat
10	75	0.02	Marra A等	2018	Crit Care Med

1	Marra A, Pandharipande PP, Girard TD, et al. Co-Ooccurrence of post-intensive care syndrome problems among 406 survivors of critical illness [J]. Crit Care Med, 2018, 46(9): 1393-1401.
2	Pandharipande PP, Girard TD, Jackson JC, et al; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness [J]. N Engl J Med, 2013, 369(14): 1306-1316.
3	Hopkins RO, Weaver LK, Collingridge D, et al. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome [J]. Am J Respir Crit Care Med, 2005, 171(4): 340-347.
4	Ehlenbach WJ, Hough CL, Crane PK, et al. Association between acute care and critical illness hospitalization and cognitive function in older adults [J]. JAMA, 2010, 303(8): 763-770.
5	Herridge MS, Tansey CM, Matté A, et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome [J]. N Engl J Med, 2011, 364(14): 1293-1304.
6	Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference [J]. Crit Care Med, 2012, 40(2): 502-509.
7	Rawal G, Yadav S, Kumar R. Post-intensive care syndrome: an overview [J]. J Transl Int Med, 2017, 5(2): 90-92.
8	陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能 [J]. 科学学研究, 2015, 33(2): 242-253.
9	Parker AM, Sricharoenchai T, Raparla S, et al. Posttraumatic stress disorder in critical illness survivors: a meta-analysis [J]. Crit Care Med, 2015, 43(5): 1121-1129.
10	Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit [J]. Crit Care Med, 2013, 41(1): 263-306.
11	Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study [J]. Lancet, 2020, 395(10219): 200-211.
12	Zhang Z, Spieth PM, Chiumello D, et al. Declining mortality in patients with acute respiratory distress syndrome: an analysis of the acute respiratory distress syndrome network trials [J]. Crit Care Med, 2019, 47(3): 315-323.
13	Herridge MS, Tansey CM, Matté A, et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome [J]. N Engl J Med, 2011, 364(14): 1293-304.
14	Worsham CM, Banzett RB, Schwartzstein RM. Dyspnea, acute respiratory failure, psychological trauma, and post-icu mental health: a caution and a call for research [J]. CHEST, 2021, 159(2): 749-756.
15	Viake JH, Wesselius S, Van Genderen ME, et al. Psychological distress and health-related quality of life in patients after hospitalization during the COVID-19 pandemic: A single-center, observational study [J]. PLoS One, 2021, 16(8): e0255774.
16	Mikkelsen ME, Christie JD, Lanken PN, et al. The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury [J]. Am J Respir Crit Care Med, 2012, 185(12): 1307-1315.
17	Wade DM, Brewin CR, Howell DCJ, et al. Intrusive memories of hallucination and delusion in traumatized intensive care patients: an interview study [J]. Br J Health Psychol, 2015, 20(3): 613-631.
18	Brummel NE, Hughes CG, Thompson JL, et al. Inflammation and coagulation during critical illness and long-term cognitive impairment and disability [J]. Am J Respir Crit Care Med, 2021, 203(6): 699-706.
19	Geense WW, de Graaf M, Vermeulen H, et al. Reduced quality of life in ICU survivors - the story behind the numbers: a mixed methods study [J]. J Crit Care, 2021, 65: 36-41.
20	谢蓉蓉. 中国ICU脓毒症患者的远期预后调查 [D]. 南京: 东南大学, 2020.
21	Van GR, Bels J, Remij L, et al. Functional outcomes and their association with physical performance in mechanically ventilated coronavirus disease 2019 survivors at 3 months following hospital discharge: a cohort study [J]. Crit Care Med, 2021, 49(10): 1726-1738.
22	Ong C, Lee JH, Wong JJM, et al. Skeletal muscle changes, function, and health-related quality of life in survivors of pediatric critical illness [J]. Crit Care Med, 2021, 49(9) : 1547-1557.
23	Curtis JR, Kentish-Barnes N, Brumback LC, et al. Facilitating communication for critically ill patients and their family members: Study protocol for two randomized trials implemented in the US and France [J]. Contemp Clin Trials, 2021, 107: 106465.
24	Navarra-Ventura G, Gomà G, de Haro C, et al. Virtual reality-based early neurocognitive stimulation in critically ill patients: a pilot randomized clinical trial [J]. J Pers Med, 2021, 11(12): 1260.
25	Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomized controlled trial [J]. Lancet, 2009, 373(9678): 1874-1882.
26	姚丽, 李镜, 丁楠楠, 等. ICU患者出院后生活质量的调查分析[J]护理学杂志, 2019, 34(15): 89-91.
27	李欣, 方亮, 李冬英, 等. ICU幸存者健康相关生活质量与社会支持及护理敏感结果关系的研究 [J]. 中国护理管理, 2020, 20(12): 1885-1889.
28	Jutte JE, Needham DM, Pfoh ER, et al. Psychometric evaluation of the Hospital Anxiety and Depression Scale 3 months after acute lung injury [J]. Crit Care, 2015, 30(4): 793-798.
29	Oeyen SG, Vandijck DM, Benoit DD, et al. Quality of life after intensive care: a systematic review of the literature [J]. Crit Care Med, 2010, 38(12): 2386-2400.

[1]	钟向娣, 任婷婷, 任丽, 刘梦碟, 周娅颖, 游月梅, 张琳玲. 全髋关节置换护理的可视化分析[J/OL]. 中华关节外科杂志(电子版), 2024, 18(02): 256-263.
[2]	奚卫, 王闻卿, 刘玥, 王亚楠, 许学斌. 胃肠炎继发脓毒症感染创伤弧菌ST14514的病原学诊断与文献病例回顾分析[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 293-302.
[3]	肖琦钦, 赵文丽, 任明君, 林丽丽, 刘尧, 苏展. 我国颞下颌关节专业学位论文的发展及演进分析[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 250-256.
[4]	许革新, 何琦, 毛智军, 普彦淞, 杨淦傑, 王建华. 我国胃肿瘤外科治疗现状及发展趋势—基于CiteSpace的可视化分析[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 350-356.
[5]	嵇振岭, 陈杰, 唐健雄. 从文献计量学分析看我国疝和腹壁外科的发展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(01): 1-12.
[6]	凌淑洵, 涂玥, 刘思逸. 间充质干细胞在慢性肾脏病研究领域现状和趋势的知识图谱可视化分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(02): 73-82.
[7]	李月刚, 关旭, 赵志勋, 权继传, 庄孟, 汤坚强. 结直肠癌NOSES手术的国际研究现状[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 321-328.
[8]	蒋永东, 耿启砥, 吴宇峰, 高世华. 肩锁关节脱位的文献计量学分析[J/OL]. 中华肩肘外科电子杂志, 2024, 12(03): 246-256.
[9]	杨巧巧, 佟琰, 王宏, 谢大洋, 张玉婷, 张庆涛, 于茜, 赵小淋, 曹雪莹, 周建辉. 人工肾研究：文献计量学分析[J/OL]. 中华肾病研究电子杂志, 2023, 12(05): 241-247.
[10]	王妍, 李雪珠, 黄力维, 陈辉, 杨毅, 邱海波. 重症医学领域2023年SCI论文研究热点的可视化分析[J/OL]. 中华重症医学电子杂志, 2024, 10(03): 218-226.
[11]	张君怡, 郭阳阳, 李宏亮. 基于CiteSpace的脑损伤与过度通气领域研究的可视化分析[J/OL]. 中华重症医学电子杂志, 2024, 10(02): 173-181.
[12]	胡杰, 蔡国龙. 脓毒症合并低心功能指数患者PiCCO参数的聚类分析[J/OL]. 中华重症医学电子杂志, 2024, 10(01): 25-30.
[13]	张耕毓, 唐冲, 张昆, 张辉, 张清华, 刘家帮. 股骨头坏死髓芯减压术的文献计量学分析及单中心病例报道[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 771-780.
[14]	徐德全, 荣洁, 谢鑫, 侯利民. 老年急诊医学研究趋势热点：基于CiteSpace的可视化分析[J/OL]. 中华老年病研究电子杂志, 2024, 11(02): 31-35.
[15]	韩转转, 秦兆亮, 俞宙, 朱婕, 陈意飞. 院外心脏骤停领域的研究进展和热点追踪[J/OL]. 中华卫生应急电子杂志, 2024, 10(02): 82-90.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Analysis of international research hotspots and trends in post-ICU syndrome based on scientific knowledge graph

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Analysis of international research hotspots and trends in post-ICU syndrome based on scientific knowledge graph