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中华重症医学电子杂志 ›› 2025, Vol. 11 ›› Issue (01) : 27 -30. doi: 10.3877/cma.j.issn.2096-1537.2025.01.006

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严重感染与免疫功能障碍:2024年度进展与展望
吴健锋1, 裴飞1, 管向东1,()   
  1. 1. 510080 广州,中山大学附属第一医院重症医学科广东省急危重症临床医学研究中心
  • 收稿日期:2025-02-14 出版日期:2025-02-28
  • 通信作者: 管向东

Severe infections and immune dysfunction:progress and prospects 2024

Jianfeng Wu1, Fei Pei1, Xiangdong Guan1,()   

  1. 1. Department of Critical Care Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangdong Clinical Research Center for Critical Care Medicine,Guangzhou 510080,China
  • Received:2025-02-14 Published:2025-02-28
  • Corresponding author: Xiangdong Guan
引用本文:

吴健锋, 裴飞, 管向东. 严重感染与免疫功能障碍:2024年度进展与展望[J/OL]. 中华重症医学电子杂志, 2025, 11(01): 27-30.

Jianfeng Wu, Fei Pei, Xiangdong Guan. Severe infections and immune dysfunction:progress and prospects 2024[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2025, 11(01): 27-30.

脓毒症作为重症医学的主要挑战,其本质是宿主免疫反应失调。本文从以下4个层面阐述其相关的最新研究进展:宿主免疫反应失调机制、免疫监测新方法、精准免疫治疗策略以及脓毒症精准治疗阶梯的发展前景,总结脓毒症免疫治疗的当前进展,探讨其面临的挑战与机遇,为脓毒症精准免疫治疗提供新思路。

Sepsis,as a major challenge in critical care medicine,is fundamentally characterized by dysregulated host immune response. This paper elucidates the latest research advancements from the following four perspectives:mechanisms of host immune response dysregulation,new methods for immune monitoring,precision immunotherapy strategies,and the developmental prospects of a stepwise approach to precision treatment in sepsis. This review summarizes current progress in sepsis immunotherapy,explores its challenges and opportunities,and provides new insights for precision immunotherapy in sepsis.

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