| 1 |
Hunt A. Sepsis：an overview of the signs，symptoms，diagnosis，treatment and pathophysiology ［J］. Emerg Nurse，2019，27（5）：32-41.
|
| 2 |
Gofton TE，Young GB. Sepsis-associated encephalopathy ［J］. Nat Rev Neurol，2012，8（10）：557-566.
|
| 3 |
Huang Y，Chen R，Jiang L，et al. Basic research and clinical progress of sepsis-associated encephalopathy ［J］. J Intensive Med，2021，1（2）：90-95.
|
| 4 |
Mazeraud A，Righy C，Bouchereau E，et al. Septic-associated encephalopathy：a comprehensive review ［J］. Neurotherapeutics，2020，17（2）：392-403.
|
| 5 |
Martin CR，Osadchiy V，Kalani A，et al. The brain-gut-microbiome axis ［J］. Cell Mol Gastroenterol Hepatol，2018，6（2）：133-148.
|
| 6 |
Wang Ⅹ，Wen Ⅹ，Yuan S，et al. Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy ［J］. Neurobiol Dis，2024，195：106499.
|
| 7 |
Zhao L，Gao Y，Guo S，et al. Sepsis-associated encephalopathy：insight into injury and pathogenesis ［J］. CNS Neurol Disord Drug Targets，2021，20（2）：112-124.
|
| 8 |
Li Z，Zhang F，Sun M，et al. The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy ［J］. PeerJ，2023，11：e15122.
|
| 9 |
Ⅹu J，Lu C，Liu Z，et al. Schizandrin B protects LPS-induced sepsis via TLR4/NF-κB/MyD88 signaling pathway ［J］. Am J Transl Res，2018，10（4）：1155-1163.
|
| 10 |
朱丹丹，于健，陆莹莹. 脓毒症相关性脑病的发病机制和潜在脑损伤标志物 ［J］. 实用休克杂志 （中英文），2019，3（3）：171-175.
|
| 11 |
Adelman MW，Woodworth MH，Langelier C，et al. The gut microbiome's role in the development，maintenance，and outcomes of sepsis ［J］. Crit Care，2020，24（1）：278.
|
| 12 |
Muratsu A，Ikeda M，Shimizu K，et al. Dynamic change of fecal microbiota and metabolomics in a polymicrobial murine sepsis model［J］. Acute Med Surg，2022，9（1）：e770.
|
| 13 |
Loh JS，Mak WQ，Tan L，et al. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases ［J］. Signal Transduct Target Ther，2024，9（1）：37.
|
| 14 |
Zhang H，Ⅹu J，Wu Q，et al. Gut microbiota mediates the susceptibility of mice to sepsis-associated encephalopathy by butyric acid ［J］. J Inflamm Res，2022，15：2103-2119.
|
| 15 |
Liao H，Li H，Bao H，et al. Short chain fatty acids protect the cognitive function of sepsis associated encephalopathy mice via GPR43 ［J］.Front Neurol，2022，13：909436.
|
| 16 |
Luo A，Li S，Wang Ⅹ，et al. Cefazolin improves anesthesia and surgery-induced cognitive impairments by modulating blood-brain barrier function，gut bacteria and short chain fatty acids ［J］. Front Aging Neurosci，2021，13：748637.
|
| 17 |
Doroszkiewicz J，Groblewska M，Mroczko B. The role of gut microbiota and gut-brain interplay in selected diseases of the central nervous system ［J］. Int J Mol Sci，2021，22（18）：10028.
|
| 18 |
Fock E，Parnova R. Mechanisms of blood-brain barrier protection by microbiota-derived short-chain fatty acids ［J］. Cells，2023，12（4）：657.
|
| 19 |
Sadler R，Cramer JV，Heindl S，et al. Short-chain fatty acids improve poststroke recovery via immunological mechanisms ［J］. J Neurosci，2020，40（5）：1162-1173.
|
| 20 |
Rose S，Bennuri SC，Davis JE，et al. Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism ［J］.Transl Psychiatry，2018，8（1）：42.
|
| 21 |
Zhou Y，Chen Y，He H，et al. The role of the indoles in microbiotagut-brain axis and potential therapeutic targets：a focus on human neurological and neuropsychiatric diseases ［J］. Neuropharmacology，2023，239：109690.
|
| 22 |
杨瑾，韦瑶，金钧. 胆汁酸与肠道菌群的相互作用及对脓毒症的影响 ［J］. 内科理论与实践，2024，19（3）：207-211.
|
| 23 |
刘艺，菅原蓁，吴彩军，等. 关注脓毒症脑病，改善脓毒症预后 ［J］.中华急诊医学杂志，2023，32（6）：719-723.
|
| 24 |
Liu Ⅹ，Chen L，Peng W，et al. Th17/Treg balance：the bloom and wane in the pathophysiology of sepsis ［J］. Front Immunol，2024，15：1356869.
|
| 25 |
Luo A，Leach ST，Barres R，et al. The microbiota and epigenetic regulation of T helper 17/regulatory t cells：in search of a balanced immune system ［J］. Front Immunol，2017，8：417.
|
| 26 |
Shakhar K，Shakhar G. Why do we feel sick when infected--can altruism play a role？ ［J］. PLoS Biol，2015，13（10）：e1002276.
|
| 27 |
Yoo BB，Mazmanian SK. The enteric network：interactions between the immune and nervous systems of the gut ［J］. Immunity，2017，46（6）：910-926.
|
| 28 |
Tan AH，Lim SY，Lang AE. The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic ［J］. Nat Rev Neurol，2022，18（8）：476-495.
|
| 29 |
孙丽薇，耿倩，郑国华. 肠道菌群-肠-脑-肌轴信号交流的研究进展 ［J］. 微生物学报，2024，64（5）：1364-1377.
|
| 30 |
李娜，李志峰，项辉，等. 迷走神经刺激对脓毒症相关性脑病大鼠的保护作用 ［J］. 中华危重病急救医学，2015，27（6）：509-513.
|
| 31 |
Costeloe K，Hardy P，Juszczak E，et al. Bifidobacterium breve BBG-001 in very preterm infants：a randomised controlled phase 3 trial ［J］.Lancet，2016，387（10019）：649-660.
|
| 32 |
Millar M，Seale J，Greenland M，et al. The microbiome of infants recruited to a randomised placebo-controlled probiotic trial （PiPS trial）［J］. EBioMedicine，2017，20：255-262.
|
| 33 |
Didari T，Solki S，Mozaffari S，et al. A systematic review of the safety of probiotics ［J］. Expert Opin Drug Saf，2014，13（2）：227-239.
|
| 34 |
Liu J，Jin Y，Li H，et al. Probiotics exert protective effect against sepsis-induced cognitive impairment by reversing gut microbiota abnormalities ［J］. J Agric Food Chem，2020，68（50）：14874-14883.
|
| 35 |
Wang L，Zhao R，Li Ⅹ，et al. Lactobacillus rhamnosus GG improves cognitive impairments in mice with sepsis ［J］. PeerJ，2024，12：e17427.
|
| 36 |
Vindigni SM，Surawicz CM. Fecal microbiota transplantation ［J］.Gastroenterol Clin North Am，2017，46（1）：171-185.
|
| 37 |
Qin H，Fu Y，Deng C，et al. The role of gut microbiota and the gut-lung axis in sepsis：a case study of a pregnant woman with severe rickettsial pneumonia and septic shock complicated by MODS ［J］. Clin Case Rep，2024，12（6）：e8815.
|
| 38 |
Li S，Guo H，Ⅹu Ⅹ，et al. Therapeutic methods for gut microbiota modification in lipopolysaccharide-associated encephalopathy ［J］.Shock，2021，56（5）：824-831.
|
| 39 |
Baxter M，Ahmad T，Colville A，et al. Fatal aspiration pneumonia as a complication of fecal microbiota transplant ［J］. Clin Infect Dis，2015，61（1）：136-137.
|
| 40 |
DeFilipp Z，Bloom PP，Torres Soto M，et al. Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant ［J］. N Engl J Med，2019，381（21）：2043-2050.
|
| 41 |
Huang ZB，Zhang GP，Lu CⅩ，et al. Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors ［J］. Exp Neurol，2025，384：115055.
|
| 42 |
Ⅹu Y，Shen B，Pan Ⅹ，et al. Palmatine ameliorated lipopolysaccharideinduced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis ［J］. Phytomedicine，2024，124：155307.
|
| 43 |
Chen L，Qing W，Yi Z，et al. NU9056，a KAT 5 inhibitor，treatment alleviates brain dysfunction by inhibiting NLRP3 inflammasome activation，affecting gut microbiota，and derived metabolites in LPStreated mice ［J］. Front Nutr，2021，8：701760.
|
| 44 |
Li S，Lv J，Li J，et al. Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve ［J］. Neurosci Lett，2018，662：98-104.
|