敌草快是与百草枯同属联吡啶类农药的非选择性速效灭生性除草剂，随着百草枯的禁用，其急性中毒事件正逐年增加。然而，对于急性敌草快中毒的损伤机制、临床表现仍认识不足。本文回顾武警特色医学中心收治的2例急性敌草快中毒致渗透性髓鞘溶解综合征（ODS）患者的救治经过，并以“敌草快”“中毒”“Diquat”“Poisoning/Intoxication/Toxicity/Overdose”为关键词检索中国知网、万方数据库、PubMed中英文数据库，查阅相似病例进行汇总分析。在检索到的12例患者中，男5例，女7例，平均年龄为（32.6±16.3）岁，服用剂量为50~120 ml，临床表现为以昏迷为主的意识障碍，磁共振成像（MRI）表现多为脑桥、丘脑、基底节等损伤区域T1加权序列低信号，T2加权序列和液体抑制反转恢复序列（FLAIR）高信号，最终死亡2例，存活10例，存活患者中有4例遗留严重后遗症。本研究提示，急性敌草快中毒，如存在昏迷等意识障碍表现，需警惕发生ODS，应尽早完善MRI予以明确，这类患者大部分预后较好，但部分可能遗留严重后遗症，应予以重视。

Diquat is a non-selective, fast-acting herbicide belonging to the bipyridinium class of pesticides like paraquat. With the ban on paraquat, acute poisoning incidents involving diquat have been increasing yearly. However, the understanding of the injury mechanisms and clinical manifestations of acute diquat poisoning remains insufficient. This article reviewed the treatment of two cases of acute diquat poisoning leading to osmotic demyelination syndrome (ODS) in the Characteristic Medical Center of Chinese People's Armed Police Force, and summarized similar cases by searching Chinese and English databases including CNKI, Wanfang, and PubMed, using keywords "Diquat" and "Poisoning/Intoxication/Toxicity/Overdose." Among 12 patients, there were five males and seven females, with an average age of (32.6±16.3) years. Ingestion doses ranged from 50 to 120 ml, with coma being the most common clinical manifestation, reflecting significant impairment of consciousness. MRI findings typically showed low signal intensity on T1-weighted sequences, and high signal intensity on T2-weighted and FLAIR sequences in damaged areas including the pons, thalamus, and basal ganglia. Two patients died, while ten survived, with four survivors experiencing severe sequelae. This study suggests that in patients with acute diquat poisoning presenting with consciousness disorders such as coma, clinicians should be alert to the potential development of ODS and consider performing early MRI examination. While most of these patients have a good prognosis, some may develop severe sequelae, which warrants attention.