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中华重症医学电子杂志 ›› 2026, Vol. 12 ›› Issue (02) : 161 -165. doi: 10.3877/cma.j.issn.2096-1537.2026.02.012

观点

心搏骤停后低温治疗:目标低温“不优于”目标常温
郭志宝1, 张丽娜2,()   
  1. 1 210009 南京,东南大学附属中大医院重症医学科
    2 410008 长沙,国家老年病临床研究中心 中南大学湘雅医院重症医学科
  • 收稿日期:2025-04-07 出版日期:2026-05-28
  • 通信作者: 张丽娜

Targeted temperature management after cardiac arrest: hypothermia "not better than" normothermia

Zhibao Guo1, Lina Zhang2,()   

  1. 1 Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
    2 Department of Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
  • Received:2025-04-07 Published:2026-05-28
  • Corresponding author: Lina Zhang
引用本文:

郭志宝, 张丽娜. 心搏骤停后低温治疗:目标低温“不优于”目标常温[J/OL]. 中华重症医学电子杂志, 2026, 12(02): 161-165.

Zhibao Guo, Lina Zhang. Targeted temperature management after cardiac arrest: hypothermia "not better than" normothermia[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2026, 12(02): 161-165.

目标体温管理(TTM)是将患者核心体温调控至特定温度以修复或减轻由血液灌注不足导致的组织损伤。TTM是心搏骤停(CA)患者心肺复苏后治疗的基石,是目前唯一被指南推荐用于CA后自主循环恢复(ROSC)仍昏迷患者脑保护的干预措施。但是近些年的临床研究结果显示与目标常温治疗相比,目标低温治疗并未能显著降低患者的病死率或改善临床预后。本文就相关内容进行论述。

Targeted temperature management (TTM) refers to the controlled reduction of core body temperature to a predefined target in order to attenuate tissue injury caused by inadequate tissue perfusion and ischemia-reperfusion damage. TTM has long been regarded as a cornerstone of post-cardiac arrest care and remains the only guideline-recommended neuroprotective strategy for comatose patients after return of spontaneous circulation (ROSC). However, an increasing number of recently published trials showed that lower-temperature TTM does not confer additional benefits in neurological outcomes or survival compared with targeted normothermia. These findings have prompted ongoing debate regarding the optimal temperature target, patient selection, and implementation strategies for post-resuscitation temperature management. This article reviews and discusses current evidence and emerging perspectives related to TTM after cardiac arrest.

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