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中华重症医学电子杂志 ›› 2026, Vol. 12 ›› Issue (02) : 202 -207. doi: 10.3877/cma.j.issn.2096-1537.2026.02.018

综述

表观遗传修饰调控急性呼吸窘迫综合征发病机制的研究进展
伍宵, 唐颖, 张曦文(), 邱海波   
  1. 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
  • 收稿日期:2024-06-03 出版日期:2026-05-28
  • 通信作者: 张曦文
  • 基金资助:
    国家自然科学基金青年项目(82202420); 国家自然科学基金重点项目(81930058,82341032)

Research progress of epigenetic modulation regulating the pathogenesis of acute respiratory distress syndrome

Xiao Wu, Ying Tang, Xiwen Zhang(), Haibo Qiu   

  1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2024-06-03 Published:2026-05-28
  • Corresponding author: Xiwen Zhang
引用本文:

伍宵, 唐颖, 张曦文, 邱海波. 表观遗传修饰调控急性呼吸窘迫综合征发病机制的研究进展[J/OL]. 中华重症医学电子杂志, 2026, 12(02): 202-207.

Xiao Wu, Ying Tang, Xiwen Zhang, Haibo Qiu. Research progress of epigenetic modulation regulating the pathogenesis of acute respiratory distress syndrome[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2026, 12(02): 202-207.

急性呼吸窘迫综合征(ARDS)是由肺内和肺外多种因素引起的以失控的炎症反应为主要特征的临床综合征,其发病率及病死率极高,已成为威胁人类健康的重要公共卫生难题之一。ARDS的发病机制复杂,近年来的研究表明表观遗传改变介导的基因调控可能在ARDS中发挥关键作用。表观遗传调控主要包括DNA甲基化、组蛋白修饰和非编码RNA(ncRNA)。表观遗传修饰反映外部环境对基因表达的影响,因此是遗传和环境相互作用的结果。本文通过对体外研究、动物实验和现有的人类ARDS表观遗传学研究进行综述,阐述表观遗传修饰介导的基因调控在ARDS发病机制中的重要作用,并为ARDS治疗提供新的靶点及方向。

Acute respiratory distress syndrome (ARDS) is a severe clinical syndrome characterized by dysregulated inflammatory response caused by intrapulmonary and extrapulmonary injuries, and remains associated with high morbidity and mortality worldwide. Despite substantial advances in supportive care, the underlying pathogenesis of ARDS has not yet been fully elucidated. Emerging evidence suggests that epigenetic regulation plays a pivotal role in the development and progression of ARDS by modulating gene expression in response to environmental and inflammatory stimuli. Major epigenetic mechanisms include DNA methylation, histone modification and non-coding RNA-mediated regulation. As epigenetic alterations represent the interface between genetic susceptibility and environmental exposure, they may provide important insights into the heterogeneity and dynamic progression of ARDS. In this review, we summarize findings from in vitro studies, animal studies, and clinical studies to elucidate the role of epigenetic modifications in ARDS pathogenesis. Furthermore, we discuss the potential of epigenetic mechanisms as novel therapeutic targets and future directions for precision treatment strategies in ARDS.

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