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中华重症医学电子杂志 ›› 2016, Vol. 02 ›› Issue (01) : 36 -39. doi: 10.3877/cma.j.jssn.2096-1537.2016.01.009

所属专题: 指南规范 文献 指南共识

指南与规范

《中国严重脓毒症/脓毒性休克治疗指南》:如何看待早期目标导向治疗
童洪杰1, 胡才宝2, 吕晓春2, 蔡国龙2,*,*()   
  1. 1. 321000 金华市中心医院重症医学科
    2. 310013 杭州,浙江医院重症医学科
  • 收稿日期:2015-02-16 出版日期:2016-02-28
  • 通信作者: 蔡国龙
  • 基金资助:
    浙江省自然科学基金项目(Y14H150020); 卫生部科学研究基金-浙江省医药卫生重大科技计划项目(WKJ2012-2-020); 浙江省医药卫生平台重点资助计划(2013ZDA001); 浙江省卫生高层次人才项目(2012)

Chinese Guidelines for Management of Severe Sepsis/Septic Shock: How to see early goal-directed therapy

Hongjie Tong1, Caibao Hu2, XiaoChun Lv2, Guolong Cai2()   

  1. 1. Department of Critical Care Medicine, Jinhua central Hospital, Jinhua 321000, China
    2. Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou 310013, China
  • Received:2015-02-16 Published:2016-02-28
  • Corresponding author: Guolong Cai
  • About author:
    Corresponding author: Cai Guolong, Email:
引用本文:

童洪杰, 胡才宝, 吕晓春, 蔡国龙. 《中国严重脓毒症/脓毒性休克治疗指南》:如何看待早期目标导向治疗[J]. 中华重症医学电子杂志, 2016, 02(01): 36-39.

Hongjie Tong, Caibao Hu, XiaoChun Lv, Guolong Cai. Chinese Guidelines for Management of Severe Sepsis/Septic Shock: How to see early goal-directed therapy[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2016, 02(01): 36-39.

严重脓毒症/脓毒性休克是重症患者死亡的重要原因。早期目标导向治疗(early goal directed therapy,EGDT)给临床提供了一个全面的复苏治疗方向,国际脓毒症指南也将其列为推荐条目。然而,近年来几项大型的随机对照研究表明,EGDT并不能降低严重脓毒症/脓毒性休克患者的病死率,因而对其临床价值产生了一定的质疑。综合分析目前关于EGDT的研究,其临床价值仍然是值得肯定的,但其方案中采用的指标本身存在一定的应用限制,并不适用于所有重症患者。是否新的复苏指标会给临床治疗提供更有效的指导,值得进一步研究。

Severe sepsis and septic shock are important causes of mortality of critically ill patients. A decade ago, early goal-directed therapy (EGDT) was used as a novel approach to reduce the mortality, and the versions of the Surviving Sepsis Campaign have incorporated it as a recommendation. However, recent randomly controlled studies have shown that EGDT could not reduce the mortality. Thus, the clinical value of EGDT is suspected. Comprehensive analysis of the studies about EGDT showed that EGDT is useful, but the major elements of this approach appear to be flawed. Possibly a new method will effectively guide clinical treatments.

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