严重脓毒症（severe sepsis）和脓毒性休克（septic shock）是重症医学的热点和焦点问题。近年来，随着对脓毒症认识的提高以及大量的临床研究的出现，对脓毒症的规范化治疗提供了丰富的临床依据，中华医学会重症医学分会近期制定了《中国严重脓毒症/脓毒性休克治疗指南》。为使读者更好地理解指南的精神，以便于更好地指导临床实践，本文将重点介绍指南制定过程中的一些关键方法及指南的一些主要亮点。

Severe sepsis and septic shock are the hot topics of critical care medicine. In recent years, sepsis has been investigated extensively and a large number of clinical trials (especially randomized controlled trials) has been published, providing a better basis for the management of sepsis. The Society of Critical Care Medicine of the Chinese Medical Association formulated the Guidelines for Management of Severe Sepsis/Septic Shock. To help physicians to better understand the guidelines and to use clinically, this paper introduces the formulation of guidelines and some principal methods.