维生素C在脓毒症中的应用进展

吕清泉; 顾小花; 吕应鸣; 郑瑞强

doi:10.3877/cma.j.issn.2096-1537.2020.031

中华重症医学电子杂志 >

2020 , Vol. 06 >Issue 01: 104 - 108

DOI: https://doi.org/10.3877/cma.j.issn.2096-1537.2020.031

综述

维生素C在脓毒症中的应用进展

吕清泉 ,
顾小花 ,
吕应鸣 ,
郑瑞强

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^1. 225000　扬州，江苏省苏北人民医院重症医学科
^2. 225700　江苏省兴化市德美康复医院普外科

通信作者：郑瑞强，Email：bonhomie2014@163.com

吕清泉,顾小花,吕应鸣,等.维生素C在脓毒症中的应用进展[J/OL].中华重症医学电子杂志, 2020, 6(1): 104-108.

收稿日期: 2019-03-22

网络出版日期: 2020-02-28

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Application of vitamin C in sepsis

Qingquan Lyu ,
Xiaohua Gu ,
Yingming Lyu ,
Ruiqiang Zheng

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^1. Department of Critical Care Medicine, Northern Jiangsu People′s Hospital, Clinical Medical College, Yangzhou University, Yangzhou 225000, China
^2. Department of General Surgery, Demei Rehabilitation Hospital, Xinghua 225700, China

Corresponding author: Zheng Ruiqiang, Email: bonhomie2014@163.com

Received date: 2019-03-22

Online published: 2020-02-28

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摘要

脓毒症是重症患者发病和死亡的主要原因。由于氧化应激时代谢消耗增加以及脱氢抗坏血酸再循环减少等原因，脓毒症患者常合并维生素C减少或缺乏。外源性补充维生素C，可能是脓毒症有效的辅助治疗措施。本文就维生素C在脓毒症中应用的作用机制、用法用量、潜在副作用、联合疗法及目前开展的临床研究等方面进行综述，旨在深化临床医师对维生素C在脓毒症治疗中的作用的认识。

关键词： 脓毒症; 维生素C; 进展

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吕清泉 , 顾小花 , 吕应鸣 , 郑瑞强 . 维生素C在脓毒症中的应用进展[J]. 中华重症医学电子杂志, 2020 , 06(01) : 104 -108 . DOI: 10.3877/cma.j.issn.2096-1537.2020.031

Abstract

Sepsis is a leading cause of morbidity and mortality in critically ill patients. Most patients with sepsis had hypovitaminosis C or vitamin C deficiency, which probably caused by increased metabolic consumption due to critically illness-induced oxidative stress and reduced recycling of dehydroascorbic acid. Therefore, repletion of vitamin C may be an effective adjuvant therapy in sepsis. We review the mechanism, dosage and usage, potential side effects, combination with others and the current clinical researches of vitamin C in sepsis management, to deepen the clinicians′ understanding the role of vitamin C in sepsis treatment.

Key words： Sepsis; Vitamin C; Improvements

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