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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) >

2021 , Vol. 07 >Issue 04: 347 - 354

DOI: https://doi.org/10.3877/cma.j.issn.2096-1537.2021.04.011

Critical Care Research

Clinical outcomes of heart dysfunction treated by extracorporeal membrane oxygenation (ECMO): a meta-analysis

  • Fei Yang 1 ,
  • Shaohua Wang 1 ,
  • Zhuang Chen 1 ,
  • Hui Shi 1 ,
  • Yun Long , 2, †
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  • 1.Department of Critical Care Medicine, Chifeng Municipal Hospital, Chifeng Clinical Medical School of Inner Mongolia Medical University, Chifeng 024000, China
  • 2.Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Corresponding author: Long Yun, Email:

Received date: 2021-07-28

  Online published: 2022-01-29

Copyright

Copyright by Chinese Medical Association No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission. All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.
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Abstract

Objective

To compare the clinical outcomes of patients with heart dysfunction treated with extracorporeal membrane oxygenation (ECMO).

Methods

PubMed, the Cochrane Library, Embase and Web of Science were searched from January 1, 1970 to December 31, 2020. Statistical analysis were performed using comprehensive meta-analysis statistical software, version 2.0.

Results

After screening for the relevant studies, 18 studies with 729 patients meeting the inclusion criteria were ultimately included. The results of the meta-analysis revealed that in patients with heart dysfunction who received ECMO intervention, the 1-month mortality rate was 36.7% (95%CI: 0.034-0.905), and in-hospital mortality was 39.8% (95%CI: 0.256-0.560). In addition, 3-month survival rate was 72.8% (95%CI: 0.621-0.814), 6-month hospitalization survival rate was 65.4% (95%CI: 0.522-0.767), and overall survival rate was 67.4% (95%CI: 0.485-0.820). Substantial heterogeneity was observed, however, sensitivity analysis showed the combined estimates were robust. No obvious publication bias existed.

Conclusion

The mid-term survival rates of patients with heart dysfunction treating by ECMO are about 60%. Future studies based on controlled trials are warranted. Subgroup analyses by different ventricular assistant device are also suggested.

Key words： Extracorporeal membrane oxygenation; Heart dysfunction; Critical care medicine

Cite this article

Fei Yang , Shaohua Wang , Zhuang Chen , Hui Shi , Yun Long . Clinical outcomes of heart dysfunction treated by extracorporeal membrane oxygenation (ECMO): a meta-analysis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021 , 07(04) : 347 -354 . DOI: 10.3877/cma.j.issn.2096-1537.2021.04.011

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