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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (03) : 226 -230. doi: 10.3877/cma.j.issn.2096-1537.2017.03.014

所属专题: 文献

综述

修复血管内皮细胞在肺栓塞中的研究进展
刘忠祥1, 戴路明1,()   
  1. 1. 650032 昆明医科大学第一附属医院重症呼吸科
  • 收稿日期:2016-12-28 出版日期:2017-08-28
  • 通信作者: 戴路明

Progress of endothelial cell repair in pulmonary embolism

Zhongxiang Liu1, Luming Dai1,()   

  1. 1. Department of Severe Respiratory Diseases, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
  • Received:2016-12-28 Published:2017-08-28
  • Corresponding author: Luming Dai
  • About author:
    Corresponding author: Dai Luming, Email:
引用本文:

刘忠祥, 戴路明. 修复血管内皮细胞在肺栓塞中的研究进展[J]. 中华重症医学电子杂志, 2017, 03(03): 226-230.

Zhongxiang Liu, Luming Dai. Progress of endothelial cell repair in pulmonary embolism[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(03): 226-230.

肺栓塞是脱落的血栓或其他物质阻塞肺动脉或其分支的病理过程,是一种具有较高发病率和死亡率的常见疾病。血管内皮细胞损伤是引发肺栓塞的重要机制之一。而血管内皮细胞损伤后再修复对治疗肺栓塞或许有一定帮助,但这需要循证医学进一步来论证。本文就血管内皮细胞损伤的机制、保护或修复血管内皮细胞的药物及其抗血栓机制作一综述,以期对将来的临床研究提供依据。

Pulmonary embolism (PE) is a pathological process of pulmonary artery or its branches blocked by free thrombus or other substances, which induce a significant morbidity and mortality. Endothelial cell injury is one of the most important mechanisms of pulmonary embolism which indicate that it may be helpful of endothelial cell repair in PE therapy. ,However, it needs to prove by evidence-based medicine. In this review, we talk about the drug of endothelial cells protection or repair and anti-thrombus in PE treatment based on the mechanism of endothelial cell injury.

图1 血栓形成机制与抗血栓或凝血药物机制图
1
中华医学会心血管病学分会肺血管病学组. 急性肺栓塞诊断与治疗中国专家共识(2015)[J]. chin J Cardial, 2016, 44(3): 197-211.
2
Huisman MV, Klok FA. Diagnostic management of acute deep vein thrombosis and pulmonary embolism[J]. J Thromb Haemost, 2013, 11(3): 412-422.
3
Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism[J]. Eur Heart J, 2014, 35(43): 3033-3069, 3069a-3069k.
4
Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis[J]. Lancet, 2012, 379(9828): 1835-1846.
5
Aleman MM, Walton BL, Byrnes JR, et al. Fibrinogen and red blood cells in venous thrombosis[J]. Thromb Res, 2014, 133(Suppl 1): S38-S40.
6
von Brühl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo[J]. J Exp Med, 2012, 209(4): 819-835.
7
Darbousset R, Thomas GM, Mezouar S, et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation[J]. Blood, 2012, 120(10): 2133-2143.
8
Diaz JA, Alvarado CM, Wrobleski SK, et al. The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse[J]. Thromb Haemost, 2013, 109(6): 1158-1169.
9
Alias S, Lang IM. Coagulation and the vessel wall in pulmonary embolism[J]. Pulm Circ, 2013, 3(4): 728-738.
10
Zapponi KC, Mazetto BM, Bittar LF, et al. Increased adhesive properties of neutrophils and inflammatory markers in venous thromboembolism patients with residual vein occlusion and high D-dimer levels[J]. Thromb Res, 2014, 133(5): 736-742.
11
Lovren F, Verma S. Evolving role of microparticles in the pathophysiology of endothelial dysfunction[J]. Clin Chem, 2013, 59(8): 1166-1174.
12
Martinod K, Wagner DD. Thrombosis: tangled up in NETs[J]. Blood, 2014, 123(18): 2768-2776.
13
Hsieh HJ, Liu CA, Huang B, et al. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications[J]. J Biomed Sci, 2014, 21: 3.
14
Vanhoutte PM, Shimokawa H, Feletou M, et al. Endothelial dysfunction and vascular disease - a 30th anniversary update[J]. Acta Physiol (Oxf), 2017, 219(1): 22-96..
15
Sun X, Belkin N, Feinberg MW. Endothelial microRNAs and atherosclerosis[J]. Curr Atheroscler Rep, 2013, 15(12): 372.
16
Peng J, Liu B, Ma QL, et al. Dysfunctional endothelial progenitor cells in cardiovascular diseases: role of NADPH oxidase[J]. J Cardiovasc Pharmacol, 2015, 65(1): 80-87.
17
Chistiakov DA, Orekhov AN, Bobryshev YV. Endothelial barrier and its abnormalities in cardiovascular disease[J]. Front Physiol, 2015, 6: 365.
18
Balaji S, King A, Crombleholme TM, et al. The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing[J]. Adv Wound Care (New Rochelle), 2013, 2(6): 283-295.
19
Alessio AM, Beltrame MP, Nascimento MC, et al. Circulating progenitor and mature endothelial cells in deep vein thrombosis[J]. Int J Med Sci, 2013, 10(12): 1746-1754.
20
Wells PS, Forgie MA, Rodger MA. Treatment of venous thromboembolism[J]. JAMA, 2014, 311(7): 717-728.
21
van der Hulle T, Dronkers CE, Klok FA, et al. Recent developments in the diagnosis and treatment of pulmonary embolism[J]. J Intern Med, 2016, 279(1): 16-29.
22
Di Nisio M, van Es N, Büller HR. et al. Deep vein thrombosis and pulmonary embolism[J]. Lancet, 2016, 388(10063): 3060-3073.
23
Marconi L, Carrozzi L, Aquilini F, et al. Five-year follow-up of pulmonary embolism under anticoaugulation: The PISA-PEET (Pulmonary Embolism Extension Therapy) study[J]. Medicine (Baltimore), 2016, 95(34): e4364.
24
Pitonzo D, Archambault ME. Riociguat for pulmonary hypertension[J]. JAAPA, 2016, 29(6): 60-62.
25
Lin CP, Lin FY, Huang PH, et al. Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation[J]. Biomed Res Int, 2013, 2013: 845037.
26
Hou X, Tong Q, Wang W, et al. Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways[J]. Life Sci, 2015, 130: 38-46.
27
Thitiwuthikiat P, Ii M, Saito T, et al. A vascular patch prepared from Thai silk fibroin and gelatin hydrogel incorporating simvastatin-micelles to recruit endothelial progenitor cells[J]. Tissue Eng Part A, 2015, 21(7-8): 1309-1319.
28
Xie L, Feng H, Li S, et al. SIRT3 mediates the antioxidant effect of hydrogen sulfide in endothelial cells[J]. Antioxid Redox Signal, 2016, 24(6): 329-343.
29
Cheang WS, Tian XY, Wong WT, et al. Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway[J]. Arterioscler Thromb Vasc Biol, 2014, 34(4): 830-836.
30
Liu HJ, Liao HH, Yang Z, et al. Peroxisome proliferator-activated receptor-γ is critical to cardiac fibrosis[J]. PPAR Res, 2016, 2016: 2198645.
31
Jin H, Gebska MA, Blokhin IO, et al. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression[J]. Arterioscler Thromb Vasc Biol, 2015, 35(4): 838-844.
32
Nayak L, Shi H, Atkins GB, et al. The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)[J]. Blood, 2014, 123(24): 3828-3831.
33
Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report[J]. Chest, 2016, 149(2): 315-352.
34
Schmidt M, Cannegieter SC, Johannesdottir SA, et al. Statin use and venous thromboembolism recurrence: a combined nationwide cohort and nested case-control study[J]. J Thromb Haemost, 2014, 12(8): 1207-1215.
35
Fadini GP, Losordo D, Dimmeler S. Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use[J]. Circ Res, 2012, 110(4): 624-637.
36
Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment[J]. Drug Des Devel Ther, 2013, 8: 49-65.
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