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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (04) : 301 -304. doi: 10.3877/cma.j.issn.2096-1537.2017.04.014

所属专题: 文献

综述

脓毒症所致急性肾损伤的研究进展
廖雪莲1, 康焰1,()   
  1. 1. 610041 成都,四川大学华西医院重症医学科
  • 收稿日期:2016-12-28 出版日期:2017-11-28
  • 通信作者: 康焰

Recent advances in sepsis-induced acute kidney injury

Xuelian Liao1, Yan Kang1,()   

  1. 1. Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
  • Received:2016-12-28 Published:2017-11-28
  • Corresponding author: Yan Kang
  • About author:
    Corresponding author: Kang Yan, Email:
引用本文:

廖雪莲, 康焰. 脓毒症所致急性肾损伤的研究进展[J/OL]. 中华重症医学电子杂志, 2017, 03(04): 301-304.

Xuelian Liao, Yan Kang. Recent advances in sepsis-induced acute kidney injury[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(04): 301-304.

脓毒症是导致重症患者发生急性肾损伤(AKI)的最重要病因,其所致AKI患者病死率明显增高,而存活者后期遗留慢性肾脏疾病的风险也明显升高。目前临床对脓毒症所致AKI的病理生理机制认识的不足,是预防和治疗这一严重综合征一直缺乏有效手段的重要原因。近年研究证据显示,微循环障碍、肾小管上皮细胞的适应性反应及炎症,在脓毒症所致AKI的发病机制中,具有至关重要的作用。因此,本文围绕脓毒症导致重症患者发生AKI的相关研究进展进行阐述,以期为临床医师及科研人员提供有益信息,为探究脓毒症所致AKI有效的治疗措施提供新思路。

Sepsis is the most common cause of acute kidney injury (AKI) among critically ill patients. Importantly, sepsis-induced AKI greatly increases the risk of death and progression to chronic kidney disease among survivors. The complex mechanisms of septic AKI was not well studied which seriously impedes the development of specific prevention and treatment strategies. Recent evidence showed that microvascular dysfunction, adaptive responses of tubular epithelial cells and in?mmation played critical role in the pathogenesis of sepsis-induced AKI. Therefore, in this review, we focus on the advances in fundamental pathophysiology of sepsis-induced AKI and provide useful information and novel ideas to clinicians and researchers for future studies.

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