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中华重症医学电子杂志 ›› 2022, Vol. 08 ›› Issue (01) : 67 -73. doi: 10.3877/cma.j.issn.2096-1537.2022.01.010

综述

头孢他啶/阿维巴坦治疗耐碳青霉烯类肠杆菌科细菌感染的研究进展
刘佩本1, 石颖1, 左祥荣1, 曹权1,()   
  1. 1. 210029 南京医科大学第一附属医院重症医学科
  • 收稿日期:2021-06-01 出版日期:2022-02-28
  • 通信作者: 曹权
  • 基金资助:
    江苏省青年医学重点人才培养项目(QNRC2016557); 江苏省高层次卫生人才“六个一工程”拔尖人才科研项目(LGY2019067); 江苏省第五期“333高层次人才培养工程”第三层次人才项目

Research progress of Ceftazidime-Avibactam in the treatment of carbapenem-resistant Enterobacteriaceae infection

Peiben Liu1, Ying Shi1, Xiangrong Zuo1, Quan Cao1,()   

  1. 1. Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2021-06-01 Published:2022-02-28
  • Corresponding author: Quan Cao
引用本文:

刘佩本, 石颖, 左祥荣, 曹权. 头孢他啶/阿维巴坦治疗耐碳青霉烯类肠杆菌科细菌感染的研究进展[J]. 中华重症医学电子杂志, 2022, 08(01): 67-73.

Peiben Liu, Ying Shi, Xiangrong Zuo, Quan Cao. Research progress of Ceftazidime-Avibactam in the treatment of carbapenem-resistant Enterobacteriaceae infection[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(01): 67-73.

耐碳青霉烯类肠杆菌科细菌(CRE)感染现呈逐年上升的趋势,临床治疗手段有限,病死率高,形势严峻。而头孢他啶/阿维巴坦(CAZ-AVI)作为一种新型的β-内酰胺类抗生素与β-内酰胺酶抑制剂的复合制剂,其批准的适应证包括复杂性尿路感染、复杂性腹腔内感染及呼吸机相关性肺炎,具有广谱、高效、作用部位广、安全性高等特点,对CRE具有较高的体外活性,成为治疗CRE感染的新选择。本文总结CAZ-AVI的药理学特点、临床应用、综合评价等方面的研究进展,探讨其临床治疗CRE感染的合理性、有效性和安全性,以期为CRE感染的治疗和CAZ-AVI的临床应用提供依据。

The infection of carbapenem-resistant Enterobacteriaceae (CRE) has been increased rapidly over the years and has become a public health threat with high mortality and limited treatment options. Ceftazidime-Avibactam (CAZ-AVI) is a novel compound mixture of β-lactam antibiotics and β-lactamase inhibitors, whose indications were currently approved including complicated urinary tract, intra-abdominal infection and ventilator-associated pneumonia. CAZ-AVI has broad antimicrobial spectrum, high-efficiency, multiple sites of antimicrobial action, and high safety profile, besides and it has evidenced activity against CRE in vitro. Thus, it becomes a new optional treatment for CRE infection. In order to explore the rationality, effectiveness and safety of CAZ-AVI for CRE treatment, the value of CAZ-AVI in the treatment of CRE infection including pharmacological characteristics, clinical efficacy and comprehensive evaluation was analyzed and summarized in this review to provide evidence for the treatment of CRE infection and the rational clinical application of CAZ-AVI.

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