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中华重症医学电子杂志 ›› 2023, Vol. 09 ›› Issue (04) : 406 -411. doi: 10.3877/cma.j.issn.2096-1537.2023.04.012

病例报告

脑动脉瘤术后交感风暴一例
何裕超, 周建芳, 王玉妹, 苗明月, 陈宏璘, 周建新, 张琳琳()   
  1. 223800 宿迁,南京医科大学附属宿迁第一人民医院神经外科
    100070 北京,首都医科大学附属北京天坛医院重症医学科
    100038 北京,首都医科大学附属北京世纪坛医院重症医学科
  • 收稿日期:2023-03-20 出版日期:2023-11-28
  • 通信作者: 张琳琳

Postoperative sympathetic storm in a cerebral aneurysm patient: case report

Yuchao He, Jianfang Zhou, Yumei Wang, Mingyue Miao, Honglin Chen, Jianxin Zhou, Linlin Zhang()   

  1. Department of Neurosurgery, Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian 223800, China
    Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
    Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2023-03-20 Published:2023-11-28
  • Corresponding author: Linlin Zhang
引用本文:

何裕超, 周建芳, 王玉妹, 苗明月, 陈宏璘, 周建新, 张琳琳. 脑动脉瘤术后交感风暴一例[J]. 中华重症医学电子杂志, 2023, 09(04): 406-411.

Yuchao He, Jianfang Zhou, Yumei Wang, Mingyue Miao, Honglin Chen, Jianxin Zhou, Linlin Zhang. Postoperative sympathetic storm in a cerebral aneurysm patient: case report[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(04): 406-411.

交感风暴是神经重症患者诊治的难点之一。本文报道1例73岁女性患者,因后循环动脉瘤破裂行择期开颅动脉瘤夹闭术,术后出现交感风暴。患者于术后第3天出现血氧饱和度下降,伴大量稀薄水性痰,头颅CT发现小脑半球缺血及间质性肺水肿,序贯经过机械通气、镇痛镇静、β受体阻滞剂、血管活性药物应用、个体化液体管理等治疗后,患者好转出院。本例患者诊疗过程及结果提示,早期识别交感风暴,并给予积极的生命支持治疗,可望取得良好的预后。神经源性肺水肿和神经源性应激性心肌病是交感风暴常见表现形式,早期诊断并采取有效的治疗,可缩短病程,改善预后,降低病死率。

Sympathetic storm is one of the difficulties when managing severe neurological patients. We reported a 73-year-old female patient who underwent selective craniotomy and aneurysm clipping procedure after rupture of posterior circulation aneurysm, who suffered from sympathetic storm after the operation. On the third post-operative day, the patient presented a deterioration in pulse oxygen saturation, accompanied by a large amount of watery sputum. Computerized tomography (CT) revealed cerebellar hemisphere ischemia and interstitial pulmonary edema. When treated with mechanical ventilation, analgesia and sedation, beta receptor blocker application and individualized fluid management, the patient got better and was finally discharged. The experience in this patient suggests that early identification of sympathetic storm and optimal organ support are necessary to achieve a good prognosis. Neurogenic pulmonary edema and neurogenic stress cardiomyopathy are common complications of sympathetic storm. Early diagnosis and effective treatment can shorten the progress, improve prognosis and reduce mortality.

图1 脑动脉瘤患者的中枢神经系统检查。图a:颅脑DSA示左侧小脑下后动脉瘤;图b:术后当日颅脑CT示未见明显出血,可见颅腔积气;图c:术后第3天颅脑CT示双侧小脑半球缺血性改变;图d:术后第10天颅脑CT示双侧小脑半球缺血性改变 注:DSA为数字减影血管造影
图2 脑动脉瘤患者呼吸系统检查。图a:术后第1天胸片示肺纹理增厚,透亮度良好;图b:术后第3天胸片示双肺透光度降低、多发片状高密度影;图c:术后第6天胸片示双肺透亮度改善、两肺纹理重、两肺野斑块片状高密度影,密度不均;图d:术后第8天胸片示两肺纹理重、两肺见斑块影及条索状密度增高影;图e:术后第3天胸部CT示两肺散在斑片状密度增高影、网格影及实变影;图f:术后第10天胸部CT示两肺多发斑块状稍高密度影、网格影,左下肺可见实变影
图3 脑动脉瘤患者循环系统检查。图a~b:左室射血分数38%,节段性室壁运动异常,左室前壁、前间隔及心尖部运动明显减弱,左房增大,左室收缩功能减低
表1 重要指标趋势图(药物剂量及化验指标均为当天上午7:00点采集)
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