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中华重症医学电子杂志 ›› 2025, Vol. 11 ›› Issue (01) : 100 -104. doi: 10.3877/cma.j.issn.2096-1537.2025.01.019

综述

脓毒症休克液体复苏的晶体液种类对急性肾损伤影响的研究进展
王冉1, 常炜1, 杨毅1, 徐静媛1,()   
  1. 1. 210009 南京,江苏省重症医学重点实验室 东南大学附属中大医院重症医学科
  • 收稿日期:2023-12-03 出版日期:2025-02-28
  • 通信作者: 徐静媛
  • 基金资助:
    国家自然科学基金项目(81971888)科技部国家重点研发计划项目(2022YFC2504400)江苏省重点研发计划项目(BE2022854)

Advance in effect of crystalloids on acute kidney injury in patients with septic shock

Ran Wang1, Wei Chang1, Yi Yang1, Jingyuan Xu1,()   

  1. 1. Department of Critical Care Medicine,Jiangsu Provincial Key Laboratory of Critical Care Medicine,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China
  • Received:2023-12-03 Published:2025-02-28
  • Corresponding author: Jingyuan Xu
引用本文:

王冉, 常炜, 杨毅, 徐静媛. 脓毒症休克液体复苏的晶体液种类对急性肾损伤影响的研究进展[J/OL]. 中华重症医学电子杂志, 2025, 11(01): 100-104.

Ran Wang, Wei Chang, Yi Yang, Jingyuan Xu. Advance in effect of crystalloids on acute kidney injury in patients with septic shock[J/OL]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2025, 11(01): 100-104.

液体复苏是治疗脓毒症休克的重要基石。最新拯救脓毒症运动(SSC)指南推荐首选晶体液对脓毒症休克进行液体复苏,但是具体给予哪种晶体液仍存在争议。经典晶体液——0.9%NaCl溶液因氯离子浓度高易导致高氯血症,对肾脏产生不利影响。因此识别0.9%NaCl溶液复苏后急性肾损伤(AKI)的高危人群至关重要。平衡盐液因组成成分更接近生理体液而受到临床医师的关注。本文就脓毒症休克液体复苏的晶体液种类对AKI影响的研究进展进行综述。

Fluid resuscitation plays an important role in the treatment of septic shock. For adults with sepsis or septic shock,crystalloid is recommended as first-line fluid for resuscitation in the latest Surviving Sepsis Campaign guidelines. The specific type of crystalloid given is still controversial. Saline is prone to hyperchloremia due to high chloride concentration and has adverse effects on the renal function. Balanced crystalloids are of interest to clinicians because their composition are closer to extracellular fluid of human body. In this paper,the advantages and disadvantages of different crystalloids and their selection were summarized based on the research of the influence of crystalloids on acute kidney injury in patients with septic shock in recent years.

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