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中华重症医学电子杂志 ›› 2021, Vol. 07 ›› Issue (03) : 263 -267. doi: 10.3877/cma.j.issn.2096-1537.2021.03.012

综述

万古霉素在成人危重症患者中的应用进展
张慧芳1, 王瑞兰1,()   
  1. 1. 201620 上海交通大学附属第一人民医院急诊危重病科
  • 收稿日期:2021-05-07 出版日期:2021-08-28
  • 通信作者: 王瑞兰
  • 基金资助:
    申康市级医院新兴前沿技术联合攻关项目(SHDC 12020106)

Vancomycin in adult critically ill patients

Huifang Zhang1, Ruilan Wang1,()   

  1. 1. Department of Critical Care Medicine, Shanghai General Hospital, Shanghai 201620, China
  • Received:2021-05-07 Published:2021-08-28
  • Corresponding author: Ruilan Wang
引用本文:

张慧芳, 王瑞兰. 万古霉素在成人危重症患者中的应用进展[J]. 中华重症医学电子杂志, 2021, 07(03): 263-267.

Huifang Zhang, Ruilan Wang. Vancomycin in adult critically ill patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(03): 263-267.

万古霉素是糖肽类杀菌剂,主要用于治疗耐药金黄色葡萄球菌和肠球菌等革兰氏阳性菌引起的严重感染。重症患者由于生理屏障被破坏,感染发生率高,而且常常合并耐药菌感染,但危重症患者因为毛细血管渗漏和器官功能障碍等使得药物在体内的药动学发生极大的改变,因此万古霉素在重症患者中的使用还需要结合具体实际情况。现就在重症患者中正确合理使用万古霉素作一综述,为优化特殊人群给药提供新思路。

Vancomycin is a glycopeptide bactericidal agent mainly used to treat serious infections caused by Gram-positive bacteria such as drug-resistant Staphylococcus aureus and Enterococcus. In critically ill patients, the incidence of infection is high due to the destruction of physiological barriers, and drug-resistant bacteria infections are common. In critically ill patients the pharmacokinetics of vancomycin is greatly altered by capillary leakage and organs dysfunction, so it is wise to use it individually in different critical situations. Literatures on the proper and rational use of vancomycin in critically ill patients is reviewed to provide ideas for optimizing the administration of this agent in these special populations.

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