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中华重症医学电子杂志 ›› 2017, Vol. 03 ›› Issue (03) : 220 -225. doi: 10.3877/cma.j.issn.2096-1537.2017.03.013

所属专题: 文献

综述

危重症相关性肾上腺皮质功能不全的研究进展
马婧1, 张伟1,()   
  1. 1. 610041 成都,四川大学华西医院内分泌科
  • 收稿日期:2016-12-27 出版日期:2017-08-28
  • 通信作者: 张伟

Progress of critical illness-related corticosteroid insufficiency

Jing Ma1, Wei Zhang1,()   

  1. 1. Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2016-12-27 Published:2017-08-28
  • Corresponding author: Wei Zhang
  • About author:
    Corresponding author:
引用本文:

马婧, 张伟. 危重症相关性肾上腺皮质功能不全的研究进展[J]. 中华重症医学电子杂志, 2017, 03(03): 220-225.

Jing Ma, Wei Zhang. Progress of critical illness-related corticosteroid insufficiency[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(03): 220-225.

尽管危重症相关性肾上腺皮质功能不全(CIRCI)在诊断和治疗方面已经取得较大进步,但是该疾病在危重症患者中仍然普遍存在,并且发病率和死亡率较高。由于CIRCI具有较强的隐蔽性,目前在临床上亦缺乏统一的诊断"金标准" ,因此确诊比较困难。同时,在临床干预方面缺乏高质量临床随机对照研究证据作支撑,且没有引起临床医师的足够关注,因此有必要对该疾病进行重新认识。本文就CIRCI的流行病学证据、可能的作用机制、诊断、治疗等作一综述,以期对将来临床研究有所帮助。

Despite considerable advances in diagnosis and treatment of the critical illness-related corticosteroid insufficiency (CIRCI), it is still common and related to high morbidity and mortality in critically ill patients. It is difficult for the clinicians to identify those patients who suffer from the disease due to the lack of diagnostic gold standard. Furthermore, CIRCI does not draw enough attention by clinicians because there is lack of high-quality clinical randomized controlled study evidence to support the clinical intervention. In this article, we will summarize the findings of previous studies about the epidemiological evidence, mechanism, diagnosis and treatment of CIRCI, aiming to help further researches in understanding of CIRCI at a more comprehensive level.

表1 CIRCI的流行病学研究
表2 CIRCI的相关实验室诊断方法及诊断效能评价
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