New progress in protection of donor liver

doi:10.3877/cma.j.issn.2096-1537.2017.02.004

Abstract

Abstract:

Liver transplantation is the unique effective treatment for patients with end-stage liver disease. With the improvement of operative technique, expansion of indications and improvement of postoperative outcomes, there are an increasing number of patients in liver transplant waiting lists. Consequently, shortage of donors becomes a serious issue in the liver transplantation community. Liver ischemia reperfusion injury (IRI) seriously restricts the utilizing of marginal donor liver, so minimizing liver ischemia reperfusion injury has a great significance in improving the effect of treatment of liver transplantation. At present, the organ donation after death is the only source of organ transplantation in China. Due to organ protection is directly associated with the quality of donor organs and recipients' outcomes following transplantation, it plays a crucial role during the work of organ donation. We reviewed recent progress in mechanism of liver ischemia reperfusion injury, evaluation of donor liver, organ procurement, liver preservation and retrieval, as well as the transport of the organs.

Key words: Organ protection, Liver preservation and retrieval, Machine perfusion, Liver ischemia reperfusion injury, Liver transplantation

Zebin Zhu, Qiang Zhao, Xiaoshun He. New progress in protection of donor liver[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2017, 03(02): 94-99.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2017.02.004

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干预药物	时间（年）	研究对象	研究类型
氯化钆^[56]	2003	猪	实验研究
甘氨酸^[57]	2005	人	前瞻性临床随机对照研究
激素（甲强龙）^[58]	2008	人	前瞻性临床随机对照研究
七氟烷^[59]	2008	鼠	实验研究
前列环素^[60]	2009	人	单中心回顾性临床研究
脱脂剂^[61]	2009	鼠	实验研究
丹酚酸B^[62]	2009	鼠	实验研究
N-乙酰半胱氨酸^[63]	2013	人	前瞻性临床随机对照研究
低剂量他克莫司^[64]	2013	人	前瞻性临床随机对照研究

干预药物	时间（年）	研究对象	研究类型
氯化钆^[56]	2003	猪	实验研究
甘氨酸^[57]	2005	人	前瞻性临床随机对照研究
激素（甲强龙）^[58]	2008	人	前瞻性临床随机对照研究
七氟烷^[59]	2008	鼠	实验研究
前列环素^[60]	2009	人	单中心回顾性临床研究
脱脂剂^[61]	2009	鼠	实验研究
丹酚酸B^[62]	2009	鼠	实验研究
N-乙酰半胱氨酸^[63]	2013	人	前瞻性临床随机对照研究
低剂量他克莫司^[64]	2013	人	前瞻性临床随机对照研究

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