Abstract:
Objective To evaluate the effects of double plasma molecular absorption system for acute hepatic failure patients.
Methods A retrospective study was conducted by collecting the data of 8 acute hepatic failure patients admitted to the intensive care unit of Shengjing Hospital, China Medical University from January 2015 till August 2016. Patients received 12 courses of DPMAS in total. Patients′ lab results were recorded at the following time points: their first and last day in ICU, before and after their first attempt of DPMAS.The data was analyzed by SPSS.
Results Six patients were discharged, while 2 patients were dead. All patients′ TBIL [(198.61±78.89) μmol/L vs (236.44±76.29) μmol/L, P=0.006], DBIL [(162.73±65.81) μmol/L vs (186.41±62.81) μmol/L, P=0.02] and UNBIL [(35.88±15.97) μmol/L vs (50.03±18.16) μmol/L, P=0.003] decreased after their first attempt of DPMAS. All patients′ PT[(18.98±5.40)s vs (16.19±3.57)s, P=0.011] were extended. They all experienced a minor drop of blood pressure during DPMAS and needed short time of norepinephrine.
Conclusions DPMAS can effectively remove bilirubin. Unfortunately, it does not reverse coagulant dysfunction and a minor drop of blood pressure may occur in the procedure.
Key words:
Hepatic failure,
Artificial liver,
Double plasma molecular absorption system
Hanyu Qin, Jia Jia, Guofu Li. Effects of double plasma molecular absorption system for acute hepatic failure patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2018, 04(01): 4-8.