Advances in Brain Lactate Metabolism

doi:10.3877/cma.j.issn.2096-1537.2018.02.017

Abstract

Abstract:

Any conditions that cause the body to produce excess lactate or insufficiently remove lactate can result in hyperlactatemia. Many tissues are able to produce lactate while the liver and the kidney are the two main organs in charge of removing lactate. The ability of different tissues to produce or remove lactate changes according to various conditions. At rest, brain only produce lactate without utilization. However, an increased blood lactate may turn brain into an organ taking and utilizing lactate. Both neurons and astrocytes could produce lactate. Glycolysis or glycogenesis in the astrocytes may be the main source of brain lactate. The production of lactate in the astrocytes is regulated by adrenergic system in locus caeruleus. In addition to acting as an energy substrate in the brain, lactate plays a role in long-term memory formation, regulation of intracerebral pH, respiratory function, humoral balance and neurovascular coupling. In addition, lactate can serves as a signal molecule and bind to GRP81 receptor in the brain. The numerous biological functions of lactate suggest that it can act as a volume-transmitting signaling molecule to participate in brain metabolism and brain function regulation. This review concentrate on advances in lactate metabolism and biological function in the brain.

Key words: Brain lactate, Metabolism, Biological functions, Astrocyte

Jingchao Li, Bin Ouyang. Advances in Brain Lactate Metabolism[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2018, 04(02): 195-199.

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https://icu.cma-cmc.com.cn/EN/Y2018/V04/I02/195

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