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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2018, Vol. 04 ›› Issue (03): 281-284. doi: 10.3877/cma.j.issn.2096-1537.2018.03.013

Special Issue:

• Review • Previous Articles     Next Articles

Tissue inhibitor of metalloproteinases-2 binding with insulin-like growth factor binding protein-7 in early diagnosis and prognostic evaluation of acute kidney injury

Xinyi Xu1, Chun Pan1, Yi Yang1()   

  1. 1. Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
  • Received:2018-02-11 Online:2018-08-28 Published:2018-08-28
  • Contact: Yi Yang

Abstract:

Acute kidney injury is a common clinical syndrome in critically ill patients. Although early diagnosis could decrease mortality significantly, traditional diagnosis biomarkers such as serum creatinine and urine output usually lag. In recent years numbers of novel biomarkers have been found. As cell cycle biomarkers related to cell injury expressed on renal tubular cell, tissue inhibitor of metalloproteinases-2 (TIMP-2) binding with insulin-like growth factor binding protein-7 (IGFBP-7) could be used in early diagnosis and prognostic evaluation of AKI.

Key words: Acute kidney injury, Cell cycle biomarker, Tissue inhibitor of metalloproteinases-2, Insulin-like growth factor binding protein-7

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