Immunological effects and clinical significance of interleukin-35 in inflammatory and autoimmune diseases

doi:10.3877/cma.j.issn.2096-1537.2018.04.004

Abstract

Abstract:

Interleukin-35 (IL-35) is a newly identified inhibitory cytokine of IL-12 family. In a variety of immune responses mediated by T and B cells, IL-35 has been proved to play a vital role of immunological regulation. IL-35 further contributes to the propagation of immune tolerance, which is crucial for maintenance of immune balance and restriction of inflammatory injuries. Heretofore, no pro-inflammatory effects of IL-35 have been discovered. Recent basic and clinical studies on inflammatory and autoimmune diseases have revealed the pathophysiological significance of IL-35 and its significant impact on the occurrence, development and prognosis of diseases. IL-35 is expected to become an important immunological marker for the diagnosis, monitoring and prognosis of inflammatory and autoimmune diseases, as well as a potential target for regulation and treatment. The in-depth study of IL-35 expression and regulation will provide new ideas and directions for clinical diagnosis and treatment of inflammatory and autoimmune diseases.

Key words: Interleukin-35, Inflammatory disease, Autoimmune disease, Immunological effect, Diagnosis, Surveillance

Tiantian Wu, Yalin Tong, Yongming Yao. Immunological effects and clinical significance of interleukin-35 in inflammatory and autoimmune diseases[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2018, 04(04): 314-319.

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https://icu.cma-cmc.com.cn/EN/Y2018/V04/I04/314

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