This patient had intermittent fever with acute myocardial infarction after thrombolytic therapy. The ultrasound showed the formation of mitral valve anterior excrescence (6 mm) . Acute kidney injury occurred 10 days after the treatment of Vancomycin combined with Piperacillin / Tazobactam for the consideration of the left-sided infective endocarditis. In the beginning, our adjustment program was the treatment of Daptomycin [dose 8 mg / (kg?d)] , but serum creatinine (Scr) continued to rise, so we adjusted the dose of 8 mg / kg?q48 h, further adjusted the dose of 6 mg / kg?q48 h. Dring the treatment with Daptomycin of 6 weeks, no further fever in patient and the erythrocyte sedimentation rate (ESR) decreased, the kidney function gradually turned to normal while the echocardiography showed the excrescence further reduced , this treatment was effective.