Relationship between active cytomegalovirus infection and Th1/Th2 cytokines in critically ill patients

doi:10.3877/cma.j.issn.2096-1537.2020.032

Abstract

Abstract:

Cytomegalovirus infection is widespread in critically ill patients. Meanwhile, CMV infection is mostly latent infection and lacks typical clinical manifestations in those patients. When CMV reactivated, it can seriously affect the outcome of critically ill patients, leading to a variety of poor prognoses. The mechanism is that CMV can affect the function of one and two cells of helper T cell (Th1/Th2). Cytomegalovirus changes the immune status of the body by regulating the number and proportion of Th1/Th2 cytokines. The mechanism can make CMV difficult to remove and easy to reactivate. Therefore, the expression of Th1/Th2 cytokines plays an extremely important role in CMV reactivation, replication and dissemination. We review the progress of relationship between active cytomegalovirus infection and Th1/Th2 cytokines in critically ill patients in this paper.

Key words: Critically ill patients, Active cytomegalovirus infection, Helper T cell one and two cytokines

Zhihui Zhang, Xiaoqing Liu. Relationship between active cytomegalovirus infection and Th1/Th2 cytokines in critically ill patients[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(01): 109-112.

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