Research progress on treatments of immunosuppression induced by sepsis

doi:10.3877/cma.j.issn.2096-1537.2020.04.017

Abstract

Abstract:

Sepsis remains the leading cause of admission and death in ICU worldwide. Recently, the key role and related poor prognosis of immune disorders in sepsis have drewmore and more interest to immunotherapy. Recent studies have shown heterogeneity in the immune responses in patients with sepsis. Some patients have immunosuppression. New immunoregulatory drugs and methods that can help restore homeostasis during sepsis may be solutions. This article reviews the most recent progress on the treatment of immunosuppressionin sepsis.

Key words: Sepsis, Immunosuppression, Review

Han Zou, Hebu Qian, Hongsheng Zhao. Research progress on treatments of immunosuppression induced by sepsis[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2020, 06(04): 453-456.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2020.04.017

https://icu.cma-cmc.com.cn/EN/Y2020/V06/I04/453

References 36

1	Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study [J]. Crit Care Med, 2006, 34(2): 344-353.
2	Shao R, Fang Y, Yu H, et al. Monocyteprogrammed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study [J]. Crit Care, 2016, 20(1): 124.
3	Chang K, Svabek C, Vazquez-Guillamet C, et al. Targeting the programmed cell death 1: Programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis [J]. Crit Care, 2014, 18(1): R3.
4	Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure [J]. JAMA, 2011, 306(23): 2594-2605.
5	Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, et al. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis [J]. Crit Care, 2012, 16(3): R112.
6	Chang KC, Burnham CA, Compton SM, et al. Blockade of the negativeco-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis [J]. Crit Care, 2013, 17(3): R85.
7	Kox WJ, Bone RC, Krausch D, et al. Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle [J]. Arch Intern Med, 1997, 157(4): 389-393.
8	Mathias B, Szpila BE, Moore FA, et al. A review of GM-CSF therapy in sepsis [J]. Medicine (Baltimore), 2015, 94(50): e2044.
9	Giacomini E, Severa M, Cruciani M, et al. Dual effect of thymosin a 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists [J]. Expert Opin Biol Ther, 2015, 15(Suppl 1): S59-S70.
10	Yang X, Qian F, He HY, et al. Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro [J]. Braz J Med Biol Res, 2012, 45(1): 25-32.
11	Liu F, Wang HM, Wang T, et al. The efficacy of thymosin a1 as immunomodulatory treatment for sepsis: a systematic review of randomized controlled trials [J]. BMC Infect Dis, 2016, 16: 488.
12	Zhang DZ, Zhou Y, Cheng QH. Effects of combined thymosin and hydrocortisone on immune response in septic mice [J]. Int J Clin Exp Med, 2015, 8(8): 12989-12994.
13	Zhu Y, Li N, He ZY, et al. Effects of Xuebijing on endothelial functions and serum inflammatory factors in patients with severe sepsis [J]. Chin J Clin Res, 2016, 29 (6): 746-748, 752.
14	Shao M, Liu B, Wang JQ, et al. Effect of Xuebijing injection on T helper 17 and CD4⁺CD25⁺ regulatory T cells in patients with sepsis [J]. Chin Crit Care Med, 2011, 23 (7): 430-434.
15	Ren Y, Wu SX, Yin X, et al. A clinical study of improvement of immunologic function in patients with old age sepsis treated by astragalus injection [J]. Chin J TCM WM Crit Care, 2014, 21 (5): 323-327.
16	李志军, 刘清泉, 沈洪, 等. 脓毒症中西医结合诊治专家共识 [J]. 中华危重病急救医学, 2013, 25(4): 194-197.
17	中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南(2014) [J]. 中华危重病急救医学, 2015, 27(6): 401-426.
18	王新芳, 张宇忠, 任丽薇, 等. 加昧生脉饮注射液对内毒素休克大鼠肺组织肿瘤坏死因子-α,白细胞介素-1β和核转录因子-κB含量的影响 [J]. 中国药师, 2011, 14(8): 1078-1081.
19	Inoue S, Bo L, Bian J, et al. Dose-dependent effect of anti-CTLA-4 on survival in sepsis [J]. Shock 2011, 36: 38-44.
20	Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, et al. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis [J]. Crit Care, 2012, 16: R112.
21	Unsinger J, McGlynn M, Kasten KR, et al. IL-7 promotes T cell viability trafficking and functionality and improves survival in sepsis [J]. J Immunol, 2010, 184(7): 3768-3779.
22	Levy Y, Lacabaratz C, Weiss L, et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment [J]. J Clin Invest, 2009, 119: 997-1007.
23	Budagian V, Bulanova E, Paus R, et al. IL-15/IL-15 receptor biology: a guided tour through an expanding universe [J]. Cytokine Growth Factor Rev, 2006, 17(4): 259-280.
24	Anguille S, Smits EL, Cools N, et al. Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties [J]. J Transl Med, 2009, 7: 109.
25	Inoue S, Unsinger J, Davis CG, et al. IL-15 prevent apoptosis reverses innate and adaptive immune dysfunction and improves survival in sepsis [J]. J Immunol, 2010, 184(3): 1401-1409.
26	Wodnar-Filipowicz A. Flt3 ligand: role in control of hematopoietic and immune functions of the bone marrow [J]. News Physiol Sci, 2003, 18: 247-251.
27	Bohannon J, Cui W, Sherwood E, et al. Dendritic cell modification of neutrophil responses to infection after burn injury [J]. J Immunol, 2010, 185(5): 2847-2853.
28	In situ vaccine for low-grade lymphoma: combination of intratumoral Flt3L and poly-ICLC with low-dose radiotherapy [EB/OL]. URL
29	Kumaresan PR, Manuri PR, Albert ND, et al. Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection [J]. Proc Nat Acad Scie USA, 2014, 111(29): 10660-10665.
30	Dotti G, Gottschalk S, Savoldo B, et al. Design and development of therapies using chimeric antigen receptor-expressing T cells [J]. Immunol Rev, 2014, 257(1): 107-126.
31	Yang WL, Ma G, Zhou M, et al. Combined administration of human ghrelin and human growth hormone attenuates organ injury and improves survival in aged septic rats [J]. Mol Med, 2016, 22: 124-135.
32	Taub DD, Murphy WJ, Longo DL. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways [J]. Curr Opin Pharmacol, 2010, 10(4): 408-424.
33	Koo GC, Huang C, Camacho R, et al. Immune enhancing effect of a growth hormone secretagogue [J]. J Immunol, 2001, 166(6): 4195-4201.
34	Narula T, de Boisblanc BP. Ghrelin in critical illness [J]. Am J Respir Cell Mol Biol, 2015, 53(4): 437-442.
35	Zhou M, Aziz M, Ochani M, et al. The protective role of human ghrelin in sepsis: restoration of CD4 T cell proliferation [J]. PLoS One, 2018, 13(7): e0201139.
36	Schorr CA, Dellinger RP. The Surviving Sepsis Campaign: past present and future [J]. Trends Mol Med, 2014, 20(4): 192-194.

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