To understand the changes of thrombelastography in surgical and medical patients with hypertensive intracerebral hemorrhage.

The clinical data of 131 hypertensive intracerebral hemorrhage patients were retrospectively collected in our hospital from May 2016 to June 2018. Patients were divided into the surgical group and medical group according to whether received operation or not. Seventeen healthy volunteers who underwent physical check-ups were selected as the control group. All the patients were tested by thrombelastography before and after treatment. The control group was only tested once when underwent physical check-ups. The results of thrombelastography in the three group were compared.

Before treatment, R value, K value, a angle, MA value and CI value were significantly different among three groups as well as different in each two group comparisons (P＜0.05). Similar results were found after treatment except K value, a angle, CI value between non-surgical group and normal control group. Significant differences of the R value, K value, a angle, MA value and CI value were found between before and after treatment in both surgical and medical group (P＜0.05). There was a negative correlation between the blood loss and the CI at admission (r=-0.618, P=0.001), the CI at admission and total blood loss in patients undergoing surgical treatment (r=-0.666, P=0.001), the blood loss at admission and post-treatment CI (r=-0.697, P=0.001). Total bleeding in patients undergoing surgical treatment had no association with post-treatment CI (r=-0.038, P=0.760).

Patients with hypertensive intracerebral hemorrhage had abnormal clotting factors, clot formation rate, fibrin and platelet function. The indicators of both surgical and medical patients improved after treatment.