Assessment of muscle mass in critically ill patients: role of the molecular biomarkers and images studies

doi:10.3877/cma.j.issn.2096-1537.2022.04.016

Abstract

Abstract:

Sarcopenia is common in critically ill patients and is associated with poor ICU outcomes. Anthropometric measurements and serum albumin are currently unreliable for determining muscle mass. Several new techniques for the diagnosis and prognosis of sarcopenia in the ICU, including dual-energy X-ray absorptiometry, computed tomography scanning, ultrasonography, and bioimpedance analysis, have been studied and validated. However, most critically ill patients do not have access to these techniques. Urea/creatinine and creatinine/cystatin C have recently been identified as an accurate method for diagnosing sarcopenia, predicting ICU outcomes, and assessing nutritional status in critically ill patients. This review of skeletal muscle quality assessment in ICU patients focuses on relevant evidence on the advantages and limitations of relevant imaging techniques and serological biomarkers suitable for application in ICU patients.

Key words: Sarcopenia, Skeletal muscle, Computed tomography, Urea/creatinine, Creatinine/cystatin C

Yan Yao, Huibin Huang. Assessment of muscle mass in critically ill patients: role of the molecular biomarkers and images studies[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(04): 371-377.

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URL: https://icu.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2096-1537.2022.04.016

https://icu.cma-cmc.com.cn/EN/Y2022/V08/I04/371

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