Due to the specificities of diagnosis and treatment process in critical care medicine, critical care data is characterized by wide dimensionality, high density and strong time-series, which has a strong demand for informationization realization and improvement of medical data processing efficiency. Since 2019, the Department of Critical Care Medicine of West China Hospital, together with the Information Center of West China Hospital and the Biomedical Data Center of West China Hospital, has basically completed the construction of West China Critical Care Medicine big data platform through a period of about 3 years. This article aimes to introduce and share the system architecture design, data interfacing and integration, database structure, data governance, data security, and database management of the West China Critical Care medicine database.