Mechanism of high mobility group box protein 1 mediated sepsis-induced coagulopathy and treatment progress

doi:10.3877/cma.j.issn.2096-1537.2023.03.006

Abstract

Abstract:

Coagulation dysfunction is a common complication in septic patients, leading to a significant increase in mortality. High mobility group box protein 1 (HMGB1), as a late inflammatory cytokine, mediates the occurrence and development of sepsis-induced coagulopathy. HMGB1 released into blood can cause hypercoagulability, inducing formation of disseminated intravascular coagulation, and leading to multiple organ failure. Therefore, intervention of HMGB1 may serve as a potential therapeutic target for sepsis-induced coagulopathy. This paper reviews the mechanism by which HMGB1 mediated sepsis-induced coagulopathy, as well as current approaches and clinical potential of HMGB1-targeting strategies, with the goal of providing the directions for the treatment of sepsis-induced coagulopathy.

Key words: Sepsis, High mobility group box protein 1, Sepsis-induced coagulopathy, Disseminated intravascular coagulation

Shiming Li, Wei Huang, Ling Liu. Mechanism of high mobility group box protein 1 mediated sepsis-induced coagulopathy and treatment progress[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(03): 269-273.

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https://icu.cma-cmc.com.cn/EN/Y2023/V09/I03/269

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