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Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition) ›› 2024, Vol. 10 ›› Issue (04): 384-388. doi: 10.3877/cma.j.issn.2096-1537.2024.04.012

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Advances in transcriptomics in diagnosis and management of sepsis

Xiang Yang1,2, Lanqi Guo1, Jianfeng Xie1, Haibo Qiu1,()   

  1. 1.Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
    2.Department of Geriatrics, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, China
  • Received:2023-08-26 Online:2024-11-28 Published:2025-01-20
  • Contact: Haibo Qiu

Abstract:

Sepsis is an acute severe syndrome that develops into fatal organ dysfunction due to infection induced uncontrolled host response.Due to its complex and heterogeneous pathophysiology, sepsis has become the leading cause of death in critically ill patients.Transcriptomics refers to the collection of all transcription products in a cell under certain physiological or pathological conditions which reflects cellular activities in a specific environment and being studied with gene transcription and transcriptional regulation.In recent years, transcriptomics has made some breakthroughs in early identification, precise treatment and prognostic evaluation of sepsis, which is potential to construct a new system for diagnosing and managing sepsis.This paper reviews related articles to clarify research progress of transcriptomics in sepsis diagnosis and treatment.

Key words: Sepsis, Transcriptomics, Diagnosis, Treatment

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